Mathematical modeling of pattern formation in Wnt signaling
Abstract: The focus of this project is mathematical modeling of spatio-temporal dynamics of Wnt signaling leading to spatial gradients and spatio-temporal oscillations in Wnt expression, and of their impact on symmetry breaking, cell proliferation and differentiation. Mathematical modeling is a powerful technique to address key questions in model systems and to provide a mechanistic understanding of the underlying processes. Mathematical models will be built and validated iteratively, based on data provided by collaborating projects. This will not only contribute to a better understanding of the underlying molecular mechanisms, but will also allow comparing the mechanisms and function of Wnt signaling in systems spanning a wide range of metazoan evolutionary change.