Dr. med. Tianzuo Zhan

Heidelberg University
Medical Faculty Mannheim
Mannheim University Hospital
Department of Medicine II
Theodor-Kutzer-Ufer 1-3
D-68167 Mannheim
E-mail: tianzuo.zhan@umm.de



Scientific CV

Academic education and professional career

since 2019
since 2019
2013 - 2018
since 2012

Fellow, DFG-Clinician Scientist Program “Interfaces and Interventions in Complex Chronic Conditions”, Heidelberg University, Medical Faculty Mannheim, Germany
Junior Research Group Leader “Translational GI Oncology”, Department of Medicine II, Mannheim University Hospital, Mannheim, Germany
Postdoctoral research fellow, Division Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany
Training in Internal Medicine, Department of Medicine II, Mannheim University Hospital, Mannheim, Germany

MD degree, Heidelberg University, Germany

Other achievements & Awards

2004 - 2011

Travel grant, German Cancer Aid, and best abstract selection, German Cancer Congress
Cancer Research award by the Oncology Working Group Mannheim
Adolf Kußmaul award by the Southwest German Society of Gastroenterology
Otto Porges abstract award by the German Society for Digestive and Metabolic Diseases
Fellowship grant by the DKFZ International Postdoc Program
Travel grant (best doctoral thesis) by the German Society for Digestive and Metabolic Diseases
Scholarship, German National Academic Foundation


  1. Zhan, T*., V. Faehling*, B. Rauscher*, J. Betge, M.P. Ebert, and M. Boutros. 2020. Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155. Int. J. Cancer. ijc.33393. PMID: 33186476
  2. Zhan T*, S. Belle*, E. Valentini, S. Herrmann, T. Miersch, M. Li, T. Gaiser, M. Boutros, M.P. Ebert, J. Betge. 2020. Cancer-associated mutations in normal colorectal mucosa adjacent to sporadic neoplasia. Clin. Transl. Gastroenterol. 11:e00212. PMID: 32764203
  3. Michels, B.E., M.H. Mosa, B.I. Streibl, T. Zhan, C. Menche, K. Abou-El-Ardat, T. Darvishi, E. Członka, S. Wagner, J. Winter, H. Medyouf, M. Boutros, and H.F. Farin. 2020. Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids. Cell Stem Cell. 26:782-792.e7. PMID: 29673923
  4. Herrmann, S.*, T. Zhan*, J. Betge, B*. Rauscher*, S. Belle, T. Gutting, N. Schulte, R. Jesenofsky, N. Härtel, T. Gaiser, R. Hofheinz, M.P. Ebert, and M. Boutros. 2019. Detection of mutational patterns in cell free DNA (cfDNA) of colorectal cancer by custom amplicon sequencing. Mol. Oncol. 13:1669–1683. PMID: 31254442
  5. Zhan, T.*, G. Ambrosi*, A.M. Wandmacher*, B. Rauscher, J. Betge, N. Rindtorff, R.S. Häussler, I. Hinsenkamp, L. Bamberg, B. Hessling, K. Müller-Decker, G. Erdmann, E. Burgermeister, M.P. Ebert, and M. Boutros. 2019a. MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer. Nat. Commun. 10:2197. PMID: 31097693
  6. Zhan, T.*, N. Rindtorff*, J. Betge, M.P. Ebert, and M. Boutros. 2019. CRISPR/Cas9 for cancer research and therapy. Semin. Cancer Biol. 55:106–119. PMID: 29673923
  7. Zhan, T.*, N. Rindtorff*, and M. Boutros. 2017. Wnt signaling in cancer. Oncogene. 36:1461–1473. PMID: 27617575
  8. Heigwer, F.*, T. Zhan*, M. Breinig, J. Winter, D. Brügemann, S. Leible, and M. Boutros. 2016. CRISPRlibrary designer (CLD): software for multispecies design of single guide RNA libraries. Genome Biol. 17:55. PMID: 27013184
  9. Zhan, T., and M. Boutros. 2015. Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells. Crit. Rev. Biochem. Mol. Biol. 1–12. PMID: 26627871
  10. Zhan, T., F. Hahn, T. Hielscher, J. Betge, G. Kähler, M.P. Ebert, and S. Belle. 2015. Frequent co-occurrence of high-grade dysplasia in large flat colonic polyps (>20 mm) and synchronous polyps. BMC Gastroenterol. 15:82. PMID: 26160557
    * shared authorship