Dr. Sergio Acebrón


Heidelberg University

Centre for Organismal Studies (COS)

Independent Research Group: Cell Signaling

Im Neuenheimer Feld 230

69120 Heidelberg


E-mail: sergio.acebron@cos.uni-heidelberg.de

Scientific CV

Academic education and professional career

since 05/2017


Independent junior group leader and lecturer, COS, Heidelberg University, Germany
Project leader / Senior postdoctoral fellow, German Cancer Research Center (DKFZ), Heidelberg, Germany
Postdoctoral fellow, German Cancer Research Center (DKFZ), Heidelberg, Germany

PhD in Biochemistry, University of the Basque Country – Biophysics Unit, Bilbao, Spain. Advisor: Prof. Arturo Muga.

B.Sc. / M.Sc. diploma in Biochemistry and Molecular Biology, University of the Basque Country, Bilbao, Spain

Other achievements & Awards

since 2018


Co-organizer of the HBIGS International Winter School “Molecular mechanisms in Mitosis”, Heidelberg, Germany
Elected representative for the junior group leaders at the HMLS Research Council, Heidelberg, Germany
CRUK Career Development Award
Appointed by the DAAD as “European Witness” (Zeugen Europas) to represent the integration of scientists within the European Union
Vice-president (2012-2014) and President (2014-2015) of the Society of Spanish Researchers in Germany (CERFA)


  1. Bufe, A., A. García del Arco, M.I. Hennecke, A. de Jaime-Soguero, M. Ostermaier, Y.C. Lin, A. Ciprianidis, U. Engel, P. Beli, H. Bastians and S.P. Acebrón‡. 2020. Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis. PNAS. 118(34):e2108145118. PMID: 34417301
  2. Giebel, N., A. de Jaime-Soguero, A. García del Arco, J.J.M. Landry, M. Tietje, L. Villacorta, V. Benes, V. Fernández-Saizand S.P. Acebrón . 2020. USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling. EMBO Reports5;22(5):e51415. PMID: 33786993
  3. Lin, YC., Haas, A., Bufe, A., Parbin, S., Hennecke, M., Voloshanenko, O., Gross, J., Boutros, M., Acebron, S.P. and H. Bastians. 2020. Wnt10b-GSK3β-dependent Wnt/STOP signaling prevents aneuploidy in
    human somatic cells. Life Science Alliance. 4(1):e202000855. PMID: 33257473
  4. Berger, B.S.*, S.P. Acebron*,#, J. Herbst, S. Koch and C. Niehrs. 2017. Parkinson associated receptor GPR37 is an ER chaperone for LRP6. EMBO Rep. 18(5):712-725. PMID: 28341812
  5. Acebrón S.P.# and C. Niehrs. 2016. β-catenin independent roles of Wnt/LRP6 signalling. Trends Cell Biol, 26(12):956-967. PMID: 27568239
  6. Koch, S.*, S.P. Acebron*, J. Herbst, G. Hatiboglu, and C. Niehrs. 2015. Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation. Cell. 163:1225-1236. PMID: 26590424
  7. Huang, Y.L., Z. Anvarian, G. Doderlein, S.P. Acebron#, and C. Niehrs. 2015. Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis. Proc Natl Acad Sci U S A. 112:5732-
    5737. PMID: 25901317
  8. Acebron, S.P. #, E. Karaulanov, B.S. Berger, Y.L. Huang, and C. Niehrs. 2014. Mitotic wnt signaling promotes protein stabilization and regulates cell size. Mol Cell. 54:663-674. PMID: 24837680
  9. Cruciat, C.M.*, B. Ohkawara*, S.P. Acebron, E. Karaulanov, C. Reinhard, D. Ingelfinger, M. Boutros, and C. Niehrs. 2010. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification
    for Wnt signaling. Science. 327:459-463. PMID: 20093472
  10. Acebron, S.P., I. Martin, U. del Castillo, F. Moro, and A. Muga. 2009. DnaK-mediated association of ClpB to protein aggregates. A bichaperone network at the aggregate surface. FEBS Lett. 583:2991-2996.
    PMID: 19698713
  11. Acebron, S.P.*, V. Fernandez-Saiz*, S.G. Taneva, F. Moro, and A. Muga. 2008. DnaJ recruits DnaK to protein aggregates. J Biol Chem. 283:1381-1390. PMID: 17984091