Prof. Dr. Ana Martin-Villalba

German Cancer Research Center (DKFZ)
Molecular Neurobiology
Im Neuenheimer Feld 581
69120 Heidelberg





Scientific CV

Academic education and professional career

since 2011
since 2011


Full Professor (W3), DKFZ, Heidelberg, Germany
Division Head, Molecular Neurobiology, DKFZ, Heidelberg, Germany
Group Leader of Molecular Neurobiology, DKFZ, Heidelberg, Germany
Project Leader in the Dept. Immungenetik, DKFZ, Heidelberg, Germany

Venia legendi (Habilitation), Heidelberg University, Germany
PhD (homologation), Spanish Ministry of Education and Culture, Spain
M.D., Heidelberg University, Germany

Other achievements & Awards


Elected as a Member of EMBO
Female Scientist Award of the German Stem Cell Network (GSCN e.v.)
Consolidator Grant, European Research Council (ERC)
President of the German Stem Cell Network (GSCN)
Heinz Maier Leibnitz-Preis
Paul Ehrlich und Ludwig Darmstädter Young Investigator Award
Walther und Christine Richtzenhain-Preis
Deutscher Akademischer Austauschdienst (DAAD), Bonn


  1. Guelcueler Balta, G.S., C. Monzel, S. Kleber, J. Beaudouin, E. Balta, T. Kaindl, S. Chen, L. Gao, M., Thiemann, C.R., Wirtz, Y., Samstag, M. Tanaka, and A. Martin-Villalba. 2019. 3D cellular architecture modulates tyrosine kinase activity switching CD95 mediated apoptosis to survival. Cell Rep. 29, 2295-2306. PMID: 31747602.
  2. Kalamakis, G., D. Bruene, S. Ravichandran, J. Bolz, W. Fan, F. Ziebell, T. Stiehl, F. Catalá-Martinez, J. Kupke, S. Zhao, E. Llorens-Bobadilla, K. Bauer, S. Limpert, B. Berger, U. Christen, P. Schmezer, J.P. Mallm, B. Berninger, S. Anders, A. DelSol, A. Marciniak-Czochra, and A. Martin-Villalba. 2019. Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain. Cell 176, 1407-1419. PMID: 30827680.
  3. Baser, A., M. Skabkin, S. Kleber, Y. Dang, G.S., Guelculer Balta, G. Kalamakis, M. Goepferich, R. Schefzik, A. Santos Lopez, E. Llorens Bobadilla, C. Schultz, B. Fischer, and A. Martin-Villalba. 2019. Onset of differentiation is posttranscriptionally controlled in adult neural stem cells. Nature 566, 100-104. PMID: 30700908.
  4. Llorens-Bobadilla, E., S. Zhao, A. Baser, G. Saiz-Castro, K. Zwadlo, and A. Martin-Villalba. 2015. Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury. Cell Stem Cell 17:329-340. PMID:26235341.
  5. Ziebell, F., A. Martin-Villalba, and A. Marciniak-Czochra. 2014. Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled
    cells. J. R. Soc. Interface. 11:20140144. PMID: 24598209
  6. Seib, D.R.M., N.S. Corsini, K. Ellwanger, C. Plass, A. Mateos, C. Pitzer, C. Niehrs, T. Celikel and A. Martin-Villalba. 2013. Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive
    decline. Cell Stem Cell. 12:204-214. Covered in the same issue of Cell Stem Cell and by National Geographic. PMID:23395445
  7. Kleber, S., I. Sancho-Martinez, B. Wiestler, A. Beisel, C. Gieffers, O. Hill, M. Thiemann, W. Mueller, J. Sykora, A. Kuhn, N. Schreglmann, E. Letellier, C. Zuliani, S. Klussmann, M. Teodorczyk, H.J. Grone,
    T.M. Ganten, H. Sultmann, J. Tuttenberg, A. von Deimling, A. Regnier-Vigouroux, C. Herold-Mende, and A. Martin-Villalba. 2008. Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell. 13:235-248. This article was picked and evaluated by “Faculty of 1000” members with a F1000 Factor of 3.2. PMID:18328427.
  8. Zuliani, C., S. Kleber, S. Klussmann, T. Wenger, M. Kenzelmann, N. Schreglmann, A. Martinez, J.A. del Rio, E. Soriano, P. Vodrazka, R. Kuner, H.-J. Groene, I. Herr, P.H. Krammer and A. Martin-Villalba. 2006. Control of neuronal branching by the death receptor CD95 (Fas / Apo-1). Cell Death Differ. 13:31-40. PMID:16003386.
  9. Demjen, D., S. Klussmann, S. Kleber, C. Zuliani, B. Stieltjes, C. Metzger, U.A. Hirt, H. Walczak, W. Falk, M. Essig, L. Edler, P.H. Krammer and A. Martin-Villalba. 2004. Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nature Medicine. 10:389-395. PMID:15004554.
  10. Martin-Villalba, A., Llorens-Bobadilla, E., and Wollny, D. 2013. CD95 in cancer: tool or target? Trends Mol. Med. 19:329-335. PMID: 23540716