Prof. Dr. Hellmut G. Augustin

 

Heidelberg University
European Center for Angioscience (ECAS)
Medical Faculty Mannheim & German Cancer Research Center (DKFZ), Heidelberg
Ludolf-Krehl-Str. 13-17
D-67167 Mannheim
 

E-mail: augustin@angioscience.de

 

Homepage

Scientific CV

Academic education and professional career

since 2018
 
since 2016
 
2011-2017
 
2011-2016
 
2011-2016
 
2006-2016
 
 
2002-2006
2001-2006
 
1992-2001
 
1997
1992

Founding Director, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Germany
Chair for Vascular Biology and Angiogenesis Research, Medical Faculty Mannheim (CBTM), Heidelberg University & German Cancer Research Center Heidelberg, Germany
Deputy Director, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Germany
Director, Center for Molecular Biology & German Cancer Research Center Alliance, Heidelberg, Germany
Speaker, Cell & Tumor Biology Research Program, German Cancer Research Center, Heidelberg, Germany
Aventis Foundation-endowed Chair for Vascular Biology and Angiogenesis Research, Medical Faculty Mannheim (CBTM), Heidelberg University, and German Cancer Research Center Heidelberg, Germany
Adjunct Professor, Medical Faculty of the Albert-Ludwigs-University Freiburg, Germany
Head, Dept. of Vascular Biology & Angiogenesis Research, Tumor Biology Center, Freiburg, Germany
Research Assistant Professor (C1, C2), University of Göttingen, Germany

Venia legendi (Habilitation) in Molecular Cell Biology, University of Göttingen, Germany
Ph.D., Cornell University, Ithaca, NY, USA; Advisor: Professor Bendicht Pauli
Dr. med. vet., School of Veterinary Medicine Hannover, Germany; Advisor: Professor Siegfried Ueberschär

Other achievements & Awards

since 2019
 
since 2016
 
since 2015
 
2014
2013-2016
 
2009-2017
since 2005
 
2005-2012
 
2003
1998-2006
1997

Speaker of the DFG Collaborative Research Center (CRC1366) ‘Vascular Control of Organ Function’ of Heidelberg University

Co-Chair of the Committee for Structure and Development of the Medical Faculty Mannheim of Heidelberg University
Member of the Steering Committee of the DFG Research Training Group (RTG2099) ‘Hallmarks of Skin Cancer’ of Heidelberg University
Heidelberg Molecular Life Sciences (HMLS) Investigator Award, Heidelberg University
Director of the Helmholtz Alliance ’Preclinical Comprehensive Cancer Center’
Speaker of the DFG Collaborative Research Center (CRC-TR23) ’Vascular Differentiation and Remodeling’ of the Universities Heidelberg and Frankfurt
Founding member and elected Chairman of VWFB e.V. (Verein zur Förderung wissenschaftlicher Fachtagungen e.v.).
Coordinator of the nationwide German Priority Research Grant SPP 1190 ’The Tumor- Vessel Interface’
Binder Innovation Award of the German Society of Cell Biology
Coordinator of nationwide German Priority Research Grant ‘Angiogenesis’ (SPP1069)
Erich-Aehnelt Award for best doctoral thesis, School of Veterinary Medicine, Hannover

Publications

  1. Gengenbacher, N., M. Singhal, C. Mogler, L. Hai, L. Milde, A.A. Abdul Pari, E. Besemfelder, C. Fricke, D. Baumann, S. Gehrs, J. Utikal, M. Felcht, J. Hu, M. Schlesner, R. Offringa, S. Chintharlapalli,
    and H.G. Augustin. 2020. Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov., CD-20-0122. PMID: 33106316
  2. Singhal, M., N. Gengenbacher, S. La Porta, S. Gehrs, J. Shi, M. Kamiyama, D.M. Bodenmiller, A. Fischl, B. Schieb, E. Besemfelder, S. Chintharlapalli, and H.G. Augustin. 2020. Preclinical validation of a novel
    metastasis-inhibiting Tie1 function-blocking antibody. EMBO Mol. Med., 12:e11164. PMID: 32302470
  3. Schlereth, K., D. Weichenhan, T. Bauer, T. Heumann, E. Giannakouri, D. Lipka, S. Jaeger, M. Schlesner, P. Aloy, R. Eils, C. Plass *, and H.G. Augustin *. 2018. The transcriptomic and epigenetic map of
    vascular quiescence in the continuous lung endothelium. Elife, pii:e34423. PMID: 29749927 (*equally contributing senior authors)
  4. Singhal, S., X. Liu, D. Inverso, K. Jiang, J. Dai, H. He, S. Bartels, W. Li, A.A. Abdul Pari, N. Gengenbacher, E. Besemfelder, L. Hui, H.G. Augustin *, and J. Hu *. 2018. Endothelial cell fitness dictates the
    source of regenerating liver vasculature. J. Exp. Med., 215:2497-2058. PMID: 30194265 (*equally contributing senior authors).
  5. La Porta, S., L. Roth, M. Singhal, C. Mogler, C. Spegg, B. Schieb, X. Qu, R.H. Adams, H.S. Baldwin, S. Savant, and H.G. Augustin. 2018. Endothelial Tie1-mediated angiogenesis and vascular abnormalization
    promote tumor progression and metastasis. J. Clin. Invest., 8:834-845. PMID: 29355844
  6. Teichert, M., L. Milde, A. Holm, L. Stanicek, N. Gengenbacher, S. Savant, T. Ruckdeschel, Z. Hasanov, K. Srivastava, J. Hu, S. Hertel, A. Bartol, K. Schlereth, and H.G. Augustin. 2017. Pericyte-expressed
    Tie2 controls vessel maturation. Nat. Commun., 8:16106. PMID: 28719590
  7. Hu, J., K. Srivastava, M. Wieland, A. Runge, C. Mogler, E. Besemfelder, D. Terhardt, M.J. Vogel, L. Cao, C. Korn, S. Bartels, M. Thomas, and H.G. Augustin. 2014. Endothelial cell-derived Angiopoietin-2
    controls liver regeneration as a spatiotemporal rheostat. Science, 343:416-419. PMID: 24458641
  8. Srivastava, K., J. Hu, C. Korn, S. Savant, M. Teichert, S.S. Kapel, M. Jugold, E. Besemfelder, M. Thomas, M. Pasparakis, and H.G. Augustin. 2014. Postsurgical adjuvant tumor therapy by combining anti-
    Angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell, 26:880-895. PMID: 25490450
  9. Alajati, A., A. M. Laib, H. Weber, A.M. Boos, A. Bartol, K. Ikenberg, T. Korff, H. Zentgraf, C. Obodozie, R. Graeser, S. Christian, G. Finkenzeller, G.B. Stark, M. Héroult, and H.G. Augustin. 2008. Spheroidbased
    engineering of a human vasculature in mice. Nat. Methods, 5:439-445. PMID: 18391960
  10. Fiedler, U., Y. Reiss, M. Scharpfenecker, V. Grunow, S. Koidl, G. Thurston, N.W. Gale, M. Witzenrath, S.Rosseau, N. Suttorp, A. Sobke, M. Herrmann, K.T. Preissner, P. Vajkoczy, and H.G. Augustin.
    2006. Angiopoietin-2 sensitizes endothelial cells to TNFa and plays a crucial role in the induction of inflammation. Nat. Med., 12: 235-239. PMID: 16462802