Prof. Dr. Holger Bastians

Georg-August University Göttingen
University Medical Center
Institute of Molecular Oncology
Section for Cellular Oncology
Grisebachstrasse 8
D-37077 Göttingen





Scientific CV

Academic education and professional career

since 2013






Professor for Cellular Oncology, University Medical Center Göttingen, Germany
Heisenberg Professor of the DFG, University Medical Center Göttingen, Germany
Heisenberg fellow of the DFG and Group leader, Institute of Molecular Oncology, University Medical Center Göttingen, Germany
Heisenberg fellow of the DFG and Group leader, Institute for Molecular Biology and Tumor Research (IMT), Phillips-University Marburg, Germany

Habilitation, Molecular Biology, Phillips-University Marburg, Germany
Group leader, Institute for Molecular Biology and Tumor Research (IMT), Phillips-University Marburg, Germany
Postdoctoral Researcher with Prof. Joan Ruderman, Department of Cell Biology, Harvard Medical School, Boston, USA

Dr. rer. nat; Topic: cell cycle regulation; German Cancer Research Center, Heidelberg and University of Osnabrück, Germany

Diploma in Biology, University of Osnabrück, Germany

Other achievements & Awards

since 2019

Speaker of the DFG research unit 2800 (FOR2800)
Binder Innovation Prize of the German Society for Cell Biology
Paper of the year Award, University Medical Center Göttingen
Heisenberg professorship of the DFG
Heisenberg fellowship of the DFG
Research fellowship of the DFG


  1. Bufe, A., A. García del Arco, M.I. Hennecke, A. de Jaime-Soguero, M. Ostermaier, Y.C. Lin, A. Ciprianidis, U. Engel, P. Beli, H. Bastians and S.P. Acebrón‡. 2020. Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis. PNAS. 118(34):e2108145118. PMID: 34417301
  2. Lin, YC., Haas, A., Bufe, A., Parbin, S., Hennecke, M., Voloshanenko, O., Gross, J., Boutros, M., Acebron, S.P. and H. Bastians. 2020. Wnt10b-GSK3β-dependent Wnt/STOP signaling prevents aneuploidy in
    human somatic cells. Life Sci Alliance. 4(1):e202000855. PMID: 33257473
  3. Schmidt, AK., Pudelko, K., Boekenkamp, JE., Berger, K., Kschischo, M., and H. Bastians. 2020. The p53/p73 - p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in
    human cancer cells. Oncogene. Published online ahead of print. PMID: 33168930.
  4. Bohly, N., Kistner, M., and H. Bastians. 2019. Mild replication stress causes aneuploidy by deregulating microtubule dynamics in mitosis. Cell Cycle. 18:2770-2783. PMID: 31448675.
  5. Bakhoum, S. F., Kabeche, L., Compton, D. A., Powell, S. N., and H. Bastians. 2017. Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities. Trends
    Cancer. 3:225-234. PMID: 28718433.
  6. Luddecke, S., Ertych, N., Stenzinger, A., Weichert, W., Beissbarth, T., Dyczkowski, J., Gaedcke, J., Valerius, O., Braus, G. H., Kschischo, M., and H. Bastians. 2016. The putative oncogene CEP72 inhibits the
    mitotic function of BRCA1 and induces chromosomal instability. Oncogene. 35:2398-2406. PMID:26300001.
  7. Ertych, N., Stolz, A., Valerius, O., Braus, G. H., and H. Bastians. 2016. CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. Proc Natl
    Acad Sci U S A. 113:1817-1822. PMID: 26831064.
  8. Stolz, A., Neufeld, K., Ertych, N., and H. Bastians. 2015. Wnt-mediated protein stabilization ensures proper mitotic microtubule assembly and chromosome segregation. EMBO Rep. 16:490-499. PMID:
  9. Stolz, A., Ertych, N., and H. Bastians. 2015. A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation. Cell Cycle. 14:827-837. PMID: 25590964.
  10. Ertych, N., Stolz, A., Stenzinger, A., Weichert, W., Kaulfuss, S., Burfeind, P., Aigner, A., Wordeman, L., and H. Bastians. 2014. Increased microtubule assembly rates influence chromosomal instability in
    colorectal cancer cells. Nature Cell Biol. 16:779-791. PMID: 24976383.
  11. Stolz, A., Ertych, N., Kienitz, A., Vogel, C., Schneider, V., Fritz, B., Jacob, R., Dittmar, G., Weichert, W., Petersen, I., and H. Bastians. 2010. The CHK2-BRCA1 tumour suppressor pathway ensures
    chromosomal stability in human somatic cells. Nature Cell Biol. 12:492-499. PMID: 20364141.