Prof. Dr. Irmgard Sinning

Heidelberg University

Biochemistry Center (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg





Scientific CV

Academic education and professional career

since 2000
1989 -1991


Board of BZH Directors, Heidelberg University, Germany
Managing Director of the BZH, Heidelberg University, Germany
Full Professor (C4), BZH, Heidelberg, Germany
Group Leader, Structural Biology Program, EMBL, Heidelberg, Germany
Scientist, Biomedical Centre, Uppsala University, Dept. Prof. Dr. Alwyn Jones, Sweden
Postdoctoral fellow, MPI for Biophysics, Frankfurt, Dept. Prof. H. Michel, Germany

PhD in Biochemistry, LMU Munich, Germany

Other achievements & Awards

since 2017
since 2017
since 2017
since 2017
since 2015
since 2015


Elected member of the Berlin-Brandenburg Academy of Sciences (BBAW)
Eduard Buchner Prize of the GBM
Member of the Steering Committee SFB1324
EMBO-YIP panel member
Founding Member of the cryo-EM network at Heidelberg University (HDcryoNet)
Member of the SAB of the IBS, Grenoble
Elected member of the Heidelberg Academy of Sciences and Humanities
Member of the SAB of the Max-Planck-Institute for Developmental Biology Tübingen
Member of the DFG nomination committee for the Leibniz programme
Karl Friedrich Bonnhoeffer Lecture, MPI-BPC Göttingen
Bayrische Verfassungsmedaille
Großer Forschungspreis der Universität Heidelberg
Gottfried Wilhelm Leibniz Preis
Member of the ERC starting grants selection committee
Steering Committee Cluster of Excellence CellNetworks

Chairperson of the DFG expert panel “Biochemistry/Biophysics”
President of the GBM
Member of the Helmholtz Senate Committee
HMLS (Heidelberg Molecular Life Science) investigator award
Elected member of Leopoldina
Elected member of EMBO
Member of the DFG expert panel “Biochemistry/Biophysics”
Member of the steering committee SFB638
GBM Board member
Editor of FEBS letters
Chairperson of the ESRF beam time committee “Life Sciences”
Organizer of four EMBO practical courses “Current methods in membrane protein research”
Member of Minerva-FemmeNET (mentoring of female scientists)
Ad hoc reviewer for the DFG and international journals, referee in the evaluation of international institutes


  1. McDowell, M.A., M. Heimes, F. Fiorentino, S. Mehmood, Á. Farkas, J. Coy-Vergara, D. Wu, J.R. Bolla, V. Schmid, R. Heinze, K. Wild, D. Flemming, S. Pfeffer, B. Schwappach, C.V. Robinson, and I. Sinning. 2020. Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex. Mol Cell. 80:72-86. PMID: 32910895
  2. Wild, K., M. Aleksić, K. Lapouge, K.D. Juaire, D. Flemming, S. Pfeffer, and I. Sinning. 2020. MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments. Nat Commun. 11:776. PMID: 32034140
  3. Zhang, Y., G. Valentín Gesé, C. Conz, K. Lapouge, J. Kopp, T. Wölfle, S. Rospert, and I. Sinning. 2020. The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat
    Commun. 11:1504. PMID: 32198371.
  4. Weyer, F.A., A. Gumiero, G.V. Gesé, K. Lapouge, and I. Sinning. 2017. Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex. Nat Struct Mol Biol. 24:144-151. PMID: 28067917
  5. Grotwinkel, J.T., K. Wild, B.Segnitz, and I. Sinning. 2014. SRP RNA remodeling by SRP68 explains its role in protein translocation. Science, 344: 101-104. PMID: 24700861.
  6. Kressler, D., G. Bange, Y. Ogawa, G. Stjepanovic, B. Bradatsch, D. Pratte, S. Amlacher, D. Strauß, Y. Yoneda, J. Katahira, I. Sinning*, and E. Hurt*. 2012. Synchronizing nuclear import of ribosomal proteins with ribosome assembly. Science 338: 666-71. PMID: 23118189. (*shared co-authorship)
  7. Stefer, S., Reitz, S., Wang, F., Wild, K., Pang, Y.Y., Schwarz, D., Bomke, J., Hein, C., Löhr, F., Bernhard F., Denic, V., Dötsch, V. and Sinning, I. 2011. Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex. Science 333: 758-62. PMID: 21719644.
  8. Stengel, K., I. Holdermann, P. Cain, C. Robinson, K. Wild, and I. Sinning. 2008. Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43. Science 321: 253-6. PMID: 18621669.
  9. Montoya, G., C. Svensson, J. Luirink, and I. Sinning. 1997. Crystal structure of the NG-domain of the signal-recognition particle receptor FtsY. Nature 385: 365-368. PMID: 9002525.
  10. Deisenhofer, J., O. Epp, I. Sinning and H. Michel. 1995. Crystallographic refinement at 2.3 Å resolution and refined model of the photosynthetic reaction centre from Rhodopseudo-monas viridis. J. Mol. Biol. 246: 429-457. PMID: 7877166.