Prof. Dr. med. Florian Leuschner

Heidelberg University
Medical Faculty Heidelberg
University Hospital Heidelberg
Department of Internal Medicine III
Im Neuenheimer Feld 410
D-69120 Heidelberg

 

E-mail: florian.leuschner@med.uni-heidelberg.de

 

Homepage

Scientific CV

Academic education and professional career

2020
since 2018
since 2018
since 2018
 
2017
2015
 
since 2014
2013
since 2012
 
2009 - 2012
2005

Specialist for Heart Failure (DGK certification)
Heisenberg Professorship “Immunocardiology”, Heidelberg University, Germany
Head of Interventional Valve Replacement (TAVI), University Hospital Heidelberg, Germany
Head of the interdisciplinary “Carditis-Team”, University Hospital Heidelberg, Germany
Medical Specialist for Interventional Cardiology (DGK certification)
Medical Specialist for Cardiology

Habilitation (Venia legendi) for Internal Medicine, Supervisor: Prof. H. Katus, Heidelberg University, Germany
Senior Physician, University Hospital Heidelberg, Germany
Medical Specialist for Internal Medicine
Research Group Leader, University Hospital Heidelberg, Germany
Postdoctoral Fellow, Supervisor: Prof. Matthias Nahrendorf, Massachusetts General Hospital/ Harvard Medical School, USA

Doctor of Medicine, Supervisor: Prof. Vinzenz Hombach, University of Ulm, Germany

Other achievements & Awards

2021-2026
since 2019
since 2018
since 2017
2016
2015-2018
 
2015
since 2013
 
2011
2009
2009

European Coordinator Leducq Network “The Inflammatory-Fibrosis Axis in Ischemic Heart Failure
Member of the Walter Siegenthaler Society
Member of the Editorial Board Basic Research in Cardiology
Member of the Confirm Consortium (BMBF)
Science Award Walter Siegenthaler Society.
Junior Research Group of the Federal Ministry of Education and Research (BMBF, DeCaRe Consortium, member and speaker)
Publication Award German Cardiac Society (working group 10)
member/ Principal Investigator of the German Centre for Cardiovascular Research (DZHK, Partner Site HD/MA)
German Academic Exchange Service (DAAD) Stipend
Postdoctoral Fellowship German Heart Research Foundation
Klaus-Tschira Scholarship

Publications

  1. Kuhn T, Knobel J, Burkert-Rettenmaier S, Li X, Meyer IS, Jungmann A, Sicklinger F, Backs F, Lasitschka F, Müller OJ, Katus HA, Krijgsveld J, and Leuschner F. 2020. Secretome analysis of cardiomyocytes identifies PCSK6 as a novel player in cardiac remodeling after myocardial infarction. Circulation. 141:1628-1644. PMID: 32100557
  2. Sicklinger F, Zhang Y, Lavine KJ, Simon N, Bucher V, Jugold M, Lehmann L, Konstandin MH, Katus HA, Leuschner F. 2020. A Minimal-Invasive Approach for Standardized Induction of Myocardial Infarction
    in Mice. Circ Res 127:1214-1216. PMID: 32854590
  3. Leuschner F, and Nahrendorf M. 2019. Novel functions of macrophages in the heart: insights into electrical conduction, stress, and diastolic dysfunction. Eur Heart J. 41:989-994. PMID: 30945736
  4. Meyer IS, Goetzke CC, Kespohl M, Sauter M, Heuser A, Eckstein V, Vornlocher HP, Anderson DG, Haas J, Meder B, Katus HA, Klingel K, Beling A, Leuschner F. 2018. Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis. Front Immunol. 9:2303. PMID: 30349538
  5. Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, Katus HA, Hardt SE, Leuschner F. 2017. The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction. EMBO Mol Med. 9:1279-1293. PMID: 28774883
  6. Leuschner F, Courtis G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin CP, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. 2015. Silencing of CCR2 in myocarditis. Eur Heart J. 36:1478-88. PMID: 24950695
  7. Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. 2012. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 209:123-37. PMID: 22213805
  8. Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M. 2012. Myocardial infarction accelerates atherosclerosis. Nature. 487:325-9. PMID: 22763456
  9. Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M. 2011. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol. 29:1005-10. PMID: 21983520
  10. Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. 2010. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res. 107:1364-73. PMID: 20930148