Prof. Dr. Michael Boutros

Heidelberg University
Department of Cell and Molecular biology / MEDMA & DKFZ
BioQuant - Center for Quantitative Analysis of Molecular and Cellular Biosystems
Im Neuenheimer Feld 267
D-69120 Heidelberg

Scientific CV

Academic education and professional career

since 2020
since 2008
since 2008



Director, Marsilius Kolleg, Heidelberg University, Germany
Professor for Cell- and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
Head of Division, Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany
Group leader, Emmy Noether Program of the DFG, German Cancer Research Center, Heidelberg, Germany
Postdoctoral research with Norbert Perrimon, Department of Genetics, Harvard Medical School, Boston, USA

Dr. rer. nat.; European Molecular Biology Laboratory and Heidelberg University, Germany; Advisor: Prof. Marek Mlodzik

M.P.A., Kennedy School of Government, Harvard University, Boston, USA
Diploma in Biochemistry, Witten/Herdecke University and Cold Spring Harbor Laboratory,New York, USA; Advisor: Prof. Winship Herr

Other achievements & Awards

since 2020
since 2019
since 2017
since 2016
since 2014
since 2012
since 2012
since 2014

since 2008

Speaker, Research and Strategy Commission, Heidelberg University
Coordinating PI, ERC Synergy Grant DECODE
Vice-Speaker, SFB1324
Elected Member of the DFG panel 201-02 ‘Genetics’
Scientific Director (interim), German Cancer Research Center, Heidelberg, Germany
Editorial Board Member, Molecular Systems Biology
Elected member of the Senate of Heidelberg University
EMBO Member
ERC Advanced Grant
Member of the Executive Board and PI, Excellence Cluster CellNetworks, Heidelberg University
Member of the Board (Kuratorium), Studienstiftung des deutschen Volkes

Deputy Chair of Board
Vice Dean for Research, Medical Faculty Mannheim, Heidelberg University
Member of the Executive Board, and PI HBIGS (Excellence Initiative), Heidelberg University
Johann-Georg Zimmermann Award for Cancer Research
EMBO Young Investigator Award
Member of the Die Junge Akademie at the Berlin-Brandenburgischen Academy of Science and the Academy Leopoldina
Emmy-Noether Postdoctoral Fellowship and Junior Group (DFG)
Boehringer Ingelheim Ph.D. fellowship
Fellow of the Studienstiftung des deutschen Volkes


  1. Port, F., C. Strein, M. Stricker, B. Rauscher, F. Heigwer, J. Zhou, C. Beyersdorffer, J. Frei, A. Hess, K. Kern, L. Lange, N. Langner, R. Malamud, B. Pavlovic, K. Radecke, L. Schmitt, L. Voos, E. Valentini, and M.Boutros. 2020. A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. Elife. 9. PMID: 32053108
  2. Chaudhary, V., and M. Boutros. 2019. Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium. PLoS Genet. 15:e1008351. PMID: 31527874
  3. Glaeser, K., M. Urban, E. Fenech, O. Voloshanenko, D. Kranz, F. Lari, J.C. Christianson, and M. Boutros. 2018. ERAD-dependent control of the Wnt secretory factor Evi. EMBO J. 37. PMID: 29378775
  4. Billmann, M., V. Chaudhary, M. ElMaghraby, B. Fischer, and M. Boutros. 2018. Widespread rewiring of genetic networks upon cancer signaling pathway activation. Cell Systems 6: 52-64. PMID: 29199019
  5. Augustin, I., Dewi, D.L., Hundshammer, J., Erdmann, G., Kerr, G., and M. Boutros. 2017. Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells. Sci Signal 10. PMID: 28074006
  6. Augustin, I., J. Gross, D. Baumann, C. Korn, G. Kerr, T. Grigoryan, C. Mauch, W. Birchmeier, and M. Boutros. 2013. Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
    The Journal of Experimental Medicine 210:1761-77. PMID: 23918954
  7. Gross, J.C., V. Chaudhary, K. Bartscherer, and M. Boutros. 2012. Active Wnt proteins are secreted on exosomes. Nat. Cell Biol. 14:1036-1045. PMID:22983114
  8. Bartscherer, K., N. Pelte, D. Ingelfinger, and M. Boutros. 2006. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell. 125:523-533. PMID:16678096
  9. Boutros, M., J. Mihaly, T. Bouwmeester, and M. Mlodzik. 2000. Signaling specificity by Frizzled receptors in Drosophila. Science. 288:1825-1828. PMID:10846164
  10. Boutros, M., N. Paricio, D.I. Strutt, and M. Mlodzik. 1998. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell. 94:109-118. PMID:9674432