Poster download: European Wnt Meeting 2018 [pdf]


Program flyer

Wednesday, September 12th

Chair: Thomas Holstein


13:00 - 13:15    Welcome, Thomas Holstein, Heidelberg, DE

13:15 - 13:40    Claudia Janda, Utrecht, NL

                         The Wnt/Frizzled axis: structure, function and engineering for

                         regenerative applications

13:40 - 14:05    Karl Willert, San Diego, US

                        Exploring WNT-FZD specificity

14:05 - 14:20    Marek Kravec, Brno, CZ

                         Dishevelled is polyglutamylated by Tubulin-tyrosine ligase-like 11 

14:20 – 14:45   Mariann Bienz, Cambridge, UK

                         The Dishevelled paradigm – signalosome assembly in animals and



14:45 - 15:15    Coffee break


Chair: Ana Martin-Villalba


15:15 - 15:40    Stefano Piccolo, Padova, IT

                         YAP/TAZ biology and regulation in stem cells regeneration and


15:40 - 15:55    Gopal P. Sapkota, Dundee, UK

                         PAWS1/FAM83G controls Wnt signalling through association with

                         Casein Kinase 1 alpha

15:55 - 16:20    Rami Hannoush, San Francisco, US

                         Pharmacological modulation of Frizzled receptors in intestinal stem


16:20 - 16:45    Yvonne Jones, Oxford, UK

                         Structural insights into extracellular modulation of Wnt signalling

16:45 - 17:00    Fei Xu, Shanghai, CN

                         Crystal structure of Frizzled 4 receptor in ligand-free state


17:00 - 18:00    Flash Talk Session I

18:00 - 20:00    Poster session I (odd Numbers) & Drinks


                         Free evening

                         Invited Speaker’s dinner in town (by invitation)


Thursday, September 13th

Chair: Edward de Robertis


09:00 - 09:25   Madelon Maurice, Utrecht, NL

                        RNF43 tumour suppressor mutations in cancer: beyond loss-of-


09:25 - 09:50   Renee van Amerongen, Amsterdam, NL

                        Wnt signaling in mammary gland biology and breast cancer: from

                        mouse to molecule 

09:50 - 10:15   Akira Kikuchi, Osaka, JP

                        The novel Dickkopfs-CKAP4 signaling pathway represents diagnostic

                        and therapeutic targets for cancer

10:15 - 10:30   Claudio Cantù, Linköping, SE

                        A new nuclear β-catenin/BCL9 partner regulates Wnt signaling

                        at the interphase between development and cancer


10:30 - 11:00   Coffee break


Chair: Elizabeth Vincan


11:00 - 11:15   Bart Williams, Grand Rapids, US

                        Frizzled Signaling in Skeletal Development and Homeostasis

11:15 - 11:40   Hendrik Korswagen, Utrecht, NL

                        Interplay between canonical and non-canonical Wnt signaling in cell


11:40 - 12:05   Michael Boutros, Heidelberg, DE

                        Mechanisms of Wnt secretion


12:05 - 13:15   Lunch


Chair: Walter Birchmeier


13:15 – 13:40  David Virshup, Singapore, SG

                        Upstream regulation of Wnt Signaling: Biology and Therapy

13:40 - 14:05   Jean-Paul Vincent, London, UK

                        Long range action of Wingless in time and space

14:05 - 14:20   Benjamin Mattes, Exeter, UK

                        Cytonemes bridge Wnt autocrine and paracrine signaling systems

14:20 - 14:35   Julia Gross, Göttingen, DE

                        Ykt6 membrane-to-cytosol cycling regulates exosomal Wnt secretion

14:35 - 15:00   Juergen Behrens, Erlangen, DE

                        Mitochondrial biogenesis induced through cell intrinsic activation of

                        Wnt signalling


15:00 - 15:30   Coffee break


Chair: Mariann Bienz


15:30 - 15:55   Edward de Robertis, Los Angeles, US

                        Regulation of Endolysosomal Microautophagy by Canonical Wnt

                        Signaling: the Role of Arginine Methylation

15:55 - 16:20   Marek Mlodzik, New York, US

                       Regulation of Wnt-signaling by ciliary protein complexes in cilia

                        independent contexts

16:20 - 16:45   Alexander Aulehla, Heidelberg, DE

                       Wnt signaling oscillations during embryonic development

16:45 - 17:00   Alexandra Schambony, Erlangen, DE   

                        The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in

                        embryonic anterior-posterior axis patterning

17:00 - 17:15   Megan Agajanian, Chapel Hill, US

                        A transcription-uncoupled negative feedback loop for the WNT

                        pathway: WNT activates the AAK1 kinase to promote clathrin-

                        mediated endocytosis of LRP6


17:15 - 18:30   Flash Talk Session II


18:30 -            Dinner buffet (parallel to Poster session)


19:00 - 21:00   Poster session II (Even Numbers)


                        Cocktails & Party


Friday, September 14th

Chair: Claudia Janda


09:00 - 09:25    Arial Zeng, Shanghai, CN

                         The functional role of Protein C Receptor in Mammary Stem Cells 

                         and  Breast Cancer

09:25 - 09:50    Walter Birchmeier, Berlin, DE

                        Inhibiting WNT and NOTCH in renal cancer stem cells: implications

                         for human patients

09:50 - 10:05    Andres Lebensohn, Bethesda, US

                         Mechanisms and physiological implications of LGR-dependent and

                         LGR-independent signaling by R-spondins

10:05 - 10:20    Bisei Ohkawara , Nagoya, JP

                         Mianserin suppresses R-spondin 2-induced activation of

                         Wnt/β-catenin signaling in chondrocytes and prevents

                         cartilage degradation in a rat model of osteoarthritis


10:20 - 10:50    Coffee break


Chair: Christof Niehrs


10:50 - 11:15    Stephane Angers, Toronto, CA

                         Identification of synthetic lethal interactions underlying cancer

                         mutations within the Wnt signaling pathway

11:15 - 11:40    Elizabeth Vincan, Melbourne, AU

                        Frizzled7 functions as a Wnt receptor in gastrointestinal epithelial

                         stem cells: implications for cancer growth and progression

11:40 - 11:55    Laura C. Zelarayán, Göttingen, DE

                        SHISA3: A novel Wnt signaling and KLF15 target in cardiac

                         endothelial cell remodelling

11:55 - 12:10    Soyoung Kim, Seoul, KR

                         TFEB is a Mediator of Wnt signalling


12:10 - 13:10    Lunch


Chair: Michael Boutros


13:10 - 13:35    Thomas Holstein, Heidelberg, DE

                        The Wnt code: deciphering early Wnt ligand-receptor interactions

13:35 - 13:50    Michaela Holzem, Oxford, UK

                         Investigating the function and evolution of Wnt ligands in

                         Drosophila melanogaster

13:50 - 14:05    Thomas Leibing, Mannheim, DE

                         Angiocrine Wnt signaling controls liver growth and metabolic

                         maturation in mice

14:05 - 14:30    Roel Nusse, Palo Alto, US

                         Gene signatures and stemness in the liver controlled by local Wnt



14:30 - 14:45    Closing and poster awards announcement


                        Speaker’s excursion (by invitation)