Sonderforschungsbereich 1324 (Collaborative Research Center 1324)

Mechanisms and functions of Wnt signaling

Physiological relevance of Wnt signaling pathways

Wnt signaling comprises a closely related group of key developmental and disease pathways. Arguably, Wnt signaling belongs to the most complex pathways. Recent discoveries in the Wnt signaling field have shed light on the intricate regulatory mechanisms that control Wnt signaling activity and its role in larger signaling networks. During recent years, significant progress has been made towards the understanding of Wnt signaling cascades.

Research program and collaborative activities

The SFB1324 research program consists of 15 projects and three technology platforms working on two research areas that are of key importance for advancing our understanding of molecular mechanisms governing Wnt signal transduction. In particular, the CRC1324 will focus on two overarching topics:

Research focus A: Wnt secretion, trafficking and receptor-ligand interactions

• How are Wnt proteins produced, how are they modified and how are they transported in the extracellularspace?
• How do Wnt ligand/receptor interactions specify the signaling response and induce different signaling cascades?

Research focus B: Wnt coupling to downstream and context-dependent signaling

• How is Wnt signaling activated and coupled to different downstream factors in a context-dependent manner?
• How are spatio-temporal dynamics of Wnt signaling controlled?

Project Project title Principal investigator Location Funding
A01 Mechanisms of Wnt protein secretion Michael Boutros
Irmgard Sinning
Heidelberg University 2017-2025
A02 Mechanisms of vascular Wnt signaling during liver homeostasis and tumorigenesis Hellmut Augustin Heidelberg University 2017-2025
A03 (E) Ykt6-dependent trafficking of Wnts Julia Gross University of Göttingen 2017-2021
A04 Roles of lipids in Wnt secretion and trafficking Britta Brügger
Michael Boutros
Heidelberg University
Heidelberg University
A05 The Wnt code: Deciphering early Wnt interactions in Hydra Thomas Holstein
Motomu Tanaka
Heidelberg University
Heidelberg University
A06 Quantitative fluorescence microscopy for the analysis of Wnt pathway interactions and dynamics Gary Davidson
G. Ulrich Nienhaus
A07 Cell-specific activation of Wnt signaling in healing after myocardial infarction Florian Leuschner Heidelberg University 2021-2025
A08 Wnt pathway specificity in niche-stem cell control Josephine Bageritz
Ingrid Lohmann
Heidelberg University 2021-2025
B01 Role of DDX56 in GSK3ß regulation during Wnt signaling Christof Niehrs DKFZ 2017-2025
B02 Mechanism of oscillatory Wnt signaling dynamics and its role in vertebrate embryos Alexander Aulehla EMBL 2017-2025
B03 The roles of Wnt signaling in genome stability Sergio P. Acebrón
Holger Bastians
Heidelberg University
University of Göttingen
B04 (E) Wnt signaling in fate determination of retinal precursors Jochen Wittbrodt Heidelberg University 2017-2021
B05 Mathematical modeling of spatiotemporal dynamics of Wnt signaling and its function in development and regeneration Anna Marciniak-Czochra Heidelberg University 2017-2025
B06 Orchestration of stem- and ETM-like phenotypes in Wnt signaling Ana Martin-Villalba DKFZ 2017-2025
B07 Uncovering novel molecular mechanisms within Wnt signaling Irmgard Sinning
Suat Özbek
Heidelberg University 2017-2025
B08 Mechanism of AXIN1 degradation after MEK inhibition Tianzuo Zhan Heidelberg University 2021-2025
B09 Wnt-cilia signaling in epithelial polarization and renal development Gislene Pereira
Matias Simons
Heidelberg University
Heidelberg University
Z01 Central administration Michael Boutros Heidelberg University 2017-2025
Z02 Advanced fluorescence microscopy G. Ulrich Nienhaus
Ulrike Engel
Heidelberg University
Z03 Advanced genetic screens and genome engineering Michael Boutros Heidelberg University 2017-2025
Z04 Advanced Proteomics Jeroen Krijgsveld Heidelberg University 2017-2025