Publications

Articles 2021

 
 
Kim M, Reinhard C, Niehrs C. Elife. 2021 Sep 30;10:e70885. doi: 10.7554/eLife.70885. PMID: 34590584


Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C, Niehrs C. Cell Rep. 2021 Aug 17;36(7):109559. doi: 10.1016/j.celrep.2021.109559. PMID: 34407399
 
 
Bufe A, García Del Arco A, Hennecke M, de Jaime-Soguero A, Ostermaier M, Lin YC, Ciprianidis A, Hattemer J, Engel U, Beli P, Bastians H, Acebrón SP. Proc Natl Acad Sci U S A. 2021 Aug 24; 118(34):e2108145118. doi:10.1073/pnas.2108145118. PMID: 34417301


Wolf LM, Lambert AM, Haenlin J, Boutros M. J Cell Sci. 2021 Jul 19:jcs.257790. doi: 10.1242/jcs.257790. Online ahead of print. PMID: 34279642
 
Ziegler B, Yiallouros I, Trageser B, Kumar S, Mercker M, Kling S, Fath M, Warnken U, Schnölzer M, Holstein TW, Hartl M, Marciniak-Czochra A, Stetefeld J, Stöcker W, Özbek S. BMC Biol. 2021 Jun 9;19(1):120.  PMID: 34107975
  Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Vélez PA, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG. Dev Cell. 2021 Jun 7;56(11):1677-1693.e10. PMID: 34038707

 

Paweł Kozielewicz, Rawan Shekhani, Stefanie Moser, Carl-Fredrik Bowin, Janine Wesslowski, Gary Davidson, and Gunnar Schulte. ACS Pharmacology & Translational Science. DOI: 10.1021/acsptsci.1c00084

 
Becker C, Lust K, Wittbrodt J. Development. 2021 Mar 15:dev.199133. doi: 10.1242/dev.199133. Online ahead of print. PMID: 33722901
 

 

Giebel N, de Jaime-Soguero A, García Del Arco A, Landry JJM, Tietje M, Villacorta L, Benes V, Fernández-Sáiz V, Acebrón SP. EMBO Rep. 2021 Mar 30:e51415. doi: 10.15252/embr.202051415. Online ahead of print. PMID: 33786993

 

Lin YC, Haas A, Bufe A, Parbin S, Hennecke M, Voloshanenko O, Gross J, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2020 Nov 30;4(1):e202000855. Print 2021 Jan. PMID: 33257473

Pre-prints 2021

BioRxiv, 2021: β-Catenin and canonical Wnts control two separate pattern formation systems in Hydra: Insights from mathematical modelling. Moritz Mercker, Tobias Lengfeld, Stefanie Höger, Anja Tursch, Mark Lommel, Thomas W Holstein, Anna Marciniak-Czochra.

Frits Veerman, Moritz Mercker, Anna Marciniak-Czochra.

Articles 2020

Phosphorylation of Ykt6 SNARE Domain Regulates Its Membrane Recruitment and Activity. Karuna M P, Witte L, Linnemannstoens K, Choezom D, Danieli-Mackay A, Honemann-Capito M, Gross JC. Biomolecules. 2020 Nov 16;10(11):E1560. PMID: 33207719

R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Lee H, Seidl C, Sun R, Glinka A, Niehrs C. Nat Commun. 2020 Nov 4;11(1):5570.  PMID: 33149137

Multiplexed conditional genome editing with Cas12a in Drosophila. Port F, Starostecka M, Boutros M. Proc Natl Acad Sci U S A. 2020 Aug 25:202004655. PMID: 32843348

Kinesin motor Klp98A mediates apical to basal Wg transport. Leonie Witte, Karen Linnemannstoens, Kevin Schmidt, Mona Honemann-Capito, Ferdinand Grawe, Andreas Wodarz, Julia Christina Gross. Development. 2020 Aug 14;147(15):dev186833. PMID: 32665246

Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium. Linnemannstöns K, Witte L, Karuna P, Kittel J, Danieli A, Müller D, Nitsch L, Honemann-Capito M, Grawe F, Wodarz A, Gross JC. Development. 2020 Aug 14;147(15):dev185421. PMID: 32611603

Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy. Eckert AF, Gao P, Wesslowski J, Wang X, Rath J, Nienhaus K, Davidson G, Nienhaus GU. Elife. 2020 May 22;9:e55286. PMID: 32441251

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled. Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G. J Biol Chem. 2020 May 7. pii: jbc.RA120.012892. PMID:32381507

Protease‐resistant streptavidin for interaction proteomics. Rafiee MR, Sigismondo G, Kalxdorf M, Förster L, Brügger B, Béthune J, Krijgsveld J. Mol Syst Biol. 2020 May;16(5):e9370. PMID: 32400114

gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection. Imkeller K, Ambrosi G, Boutros M, Huber W. Genome Biol. 2020 Mar 2; 21(1):53. PMID: 32122365

Hysteresis-driven pattern formation in reaction-diffusion-ODE systems. American Institute of Mathematical Science Alexandra Köthe, Anna Marciniak-Czochra  and  Izumi Takagi. doi: 10.3934/dcds.2020170

A Large-Scale Resource for Tissue-Specific CRISPR Mutagenesis in Drosophila. Port F, Strein C, Stricker M, Rauscher B, Heigwer F, Zhou J, Beyersdörffer C, Frei J, Hess A, Kern K, Lange L, Langner N, Malamud R, Pavlović B, Rädecke K, Schmitt L, Voos L, Valentini E, Boutros M. Elife. 2020 Feb 13;9:e53865. PMID: 32053108

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. Elife. 2020 Jan 14;9. pii: e51248. PMID: 31934854

Pre-prints 2020

BioRxiv, 2020: Wnt/β-Catenin Signaling Controls Spatio-Temporal Elasticity Patterns in Extracellular Matrix during Hydra Morphogenesis. Mariam Veschgini, Hendrik O Petersen, Fernanda F Rossetti, Wasim Abuillan, Stefan Kaufmann, Ryo Suzuki, Manfred Burghammer, Suat Özbek, Thomas W Holstein, Motomu Tanaka.

BioRxiv, 2020: MAPK signaling links the injury response to Wnt-regulated patterning in Hydra regeneration. Anja Tursch, Natascha Bartsch, Thomas W. Holstein.

BioRxiv, 2020: Allele-specific endogenous tagging and quantitative analysis of β-catenin in colon cancer cells. G. Ambrosi, O. Voloshanenko, A. Eckert, D. Kranz, U. Nienhaus, M. Boutros.

Articles 2019

Expansion of a single transposable element family is associated with genome-size increase and radiation in the genus Hydra. Wong WY, Simakov O, Bridge DM, Cartwright P, Bellantuono AJ, Kuhn A, Holstein TW, David CN, Steele RE, Martínez DE. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):22915-22917. PMID: 31659034

Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation. Puzik K, Tonnier V, Opper I, Eckert A, Zhou L, Kratzer MC, Noble FL, Nienhaus GU, Gradl D. Sci Rep. 2019 Oct 30;9(1):15645.  PMID: 31666627

Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium. Chaudhary V, Boutros M. PLoS Genet. 2019 Sep 17;15(9):e1008351. PMID: 31527874

What makes flatworms go to pieces. Holstein TW. Nature. 2019 Aug;572(7771):593-594. PMID: 31444489

Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing. Chaudhary V, Hingole S, Frei J, Port F, Strutt D, Boutros M.Development. 2019 Aug 9;146(15). PMID: 31399474

Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Cell. 2019 Mar 7;176(6):1407-1419.e14. PMID: 30827680

Enhanced in vivo-imaging in medaka by optimized anaesthesia, fluorescent protein selection and removal of pigmentation. Lischik CQ, Adelmann L, Wittbrodt J. PLoS One. 2019 Mar 7;14(3):e0212956. PMID: 30845151

Articles 2018

Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction. Lommel M, Strompen J, Hellewell AL, Balasubramanian GP, Christofidou ED, Thomson AR, Boyle AL, Woolfson DN, Puglisi K, Hartl M, Holstein TW, Adams JC, Özbek S. Sci Rep. 2018 Aug 6;8(1):11753. PMID:30082916  
Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. Mattes B, Dang Y, Greicius G, Kaufmann LT, Prunsche B, Rosenbauer J, Stegmaier J, Mikut R, Özbek S, Nienhaus GU, Schug A, Virshup DM, Scholpp S. Elife. 2018 Jul 31;7. PMID:30060804  

Post-Turing tissue pattern formation: Advent of mechanochemistry. Brinkmann F, Mercker M, Richter T, Marciniak-Czochra A. PLoS Comput Biol. 2018 Jul 3;14(7):e1006259. PMID:29969460

Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification. Melnik S, Dvornikov D, Müller-Decker K, Depner S, Stannek P, Meister M, Warth A, Thomas M, Muley T, Risch A, Plass C, Klingmüller U, Niehrs C, Glinka A. Cell Discov. 2018 Jul 3;4:37. PMID: 29977599

The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG. Elife. 2018 May 11;7. PMID:29749927

ERAD-dependent control of the Wnt secretory factor Evi. Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. EMBO J. 2018 Feb 15;37(4). PMID:29378775

β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells. Voloshanenko O, Schwartz U, Kranz D, Rauscher B, Linnebacher M, Augustin I, Boutros M. Sci Rep. 2018 Feb 16;8(1):3178. PMID:29453334

Dynamical spike solutions in a nonlocal model of pattern formation. Marciniak-Czochra, S. Härting, G. Karch and K. Suzuki (2018) Nonlinearity 31: 1757.

Reviews

Extracellular vesicles and oncogenic signaling.  Schubert A, Boutros M. Mol Oncol. 2020 Nov 18. doi: 10.1002/1878-0261.12855. Online ahead of print. PMID: 33207034

Making head or tail of cnidarian hox gene function. Rentzsch F, Holstein TW. Nat Commun. 2018 Jun 5;9(1):2187. PMID:29872045

A Cell-Based Assay for Mitotic Spindle Orientation. Glaubke E, Bastians H. Methods Mol Biol. 2018;1787:67-75. PMID:29736710

The Mingle-Mangle of Wnt Signaling and Extracellular Vesicles: Functional Implications for Heart Research. Gross JC, Zelarayán LC. Front Cardiovasc Med. 2018 Feb 22;5:10. PMID:29564334