Mechanisms and functions of Wnt signaling

Physiological relevance of Wnt signaling pathways

Wnt signaling comprises a closely related group of key developmental and disease pathways. Arguably, Wnt signaling belongs to the most complex pathways. Recent discoveries in the Wnt signaling field have shed light on the intricate regulatory mechanisms that control Wnt signaling activity and its role in larger signaling networks. During recent years, significant progress has been made towards the understanding of Wnt signaling cascades.

Research program and collaborative activities

The SFB1324 research program consists of 13 projects and three technology platforms working on two  research areas that are of key importance for advancing our understanding of molecular mechanisms governing Wnt signal transduction. In particular, the CRC1324 will focus on two overarching topics:

Research focus A: Wnt secretion, trafficking and receptor-ligand interactions

• How are Wnt proteins produced, how are they modified and how are they transported in the extracellularspace?
• How do Wnt ligand/receptor interactions specify the signaling response and induce different signaling cascades?

Research focus B: Wnt coupling to downstream and context-dependent signaling

• How is Wnt signaling activated and coupled to different downstream factors in a context-dependent manner?
• How are spatio-temporal dynamics of Wnt signaling controlled?