Publikation-Schlagwort: LRP6

Research Article

N-Glycosylation of LRP6 by B3GnT2 Promotes Wnt/β-Catenin Signalling

B3GnT2 glycosylation LRP6 polylactosamine Wnt signalling Wnt/β-catenin
Xu R, Wang X, Safi S, Braunegger N, Hipgrave Ederveen A, Rottmann M, Wittbrodt J, Wuhrer M, Wesslowski J, Davidson G. Cells. 2023 Mar 10;12(6):863. doi: 10.3390/cells12060863. PMID: 36980204
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Research Article

Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis

cilia exencephaly GSK3 lipodystrophy LRP6 PP1 Wnt
Zhang K, Da Silva F, Seidl C, Wilsch-Bräuninger M, Herbst J, Huttner WB, Niehrs C. Dev Cell. 2023 Jan 23;58(2):139-154.e8. doi: 10.1016/j.devcel.2022.12.006. PMID: 36693320
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Review

LRPs in WNT Signalling

DKK therapeutic antibodies LRP LRP4 LRP5 LRP5 disease mutations LRP6 LRP6 disease mutations LRP6 structure Sclerostin therapeutic antibodies Wnt Wnt co-receptor Wnt surrogates

Davidson G. Handb Exp Pharmacol. 2021;269:45-73. doi: 10.1007/164_2021_526. PMID: 34490514

 

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Research Article

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

cell biology developmental biology human LRP6 PTPRK spemann organizer tyrosine phosphatase Wnt signaling xenopus ZNRF3

Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. Elife. 2020 Jan 14;9. pii: e51248.

PMID: 31934854

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