Research Article

Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response

inflammation monocytes myocardial infarction Wnt signaling
Meyer IS, Li X, Meyer C, Voloshanenko O, Pohl S, Boutros M, Katus HA, Frey N, Leuschner F. Int J Mol Sci. 2022 Oct 14;23(20):12252. doi: 10.3390/ijms232012252.
PMID: 36293109
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Research Article

Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates

biomolecular condensates CRISPR Dishevelled superresolution microscopy Wnt signaling

Schubert A, Voloshanenko O, Ragaller F, Gmach P, Kranz D, Scheeder C, Miersch T, Schulz M, Trümper L, Binder C, Lampe M, Engel U, Boutros M. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122476119. doi: 10.1073/pnas.2122476119. Epub 2022 Jul 22. PMID: 35867833

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Review

The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling.

Axis formation Gradients Hydra Nematostella Nodal signaling Tgf-beta signaling Wnt signaling

Holstein TW. Dev Biol. 2022 Apr 22;487:74-98. doi: 10.1016/j.ydbio.2022.04.005. Online ahead of print.

PMID: 35461834

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Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd

AML BMP4 signaling cell differentiation dendrimer development peptides R-spondin2 TSP1 Wnt signaling xenopus
Lee H, Sun R, Niehrs C. J Biol Chem. 2022 Jan 12:101586. doi: 10.1016/j.jbc.2022.101586. Online ahead of print.
PMID: 35032551
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Research Article

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

cancer cell biology CRISPR ctnnb1 endogenous tagging FCS fluorescence correlation spectroscopy genetics genomics human β-catenin oncogenic signaling Wnt signaling
Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11:e64498. doi: 10.7554/eLife.64498.
PMID: 35014953
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Review

The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation

Axis formation Wnt signaling xenopus

Niehrs C. Dev Biol. 2022 Feb;482:1-6. doi: 10.1016/j.ydbio.2021.11.006. Epub 2021 Nov 21. PMID: 34818531

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A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

cell biology endocytosis HGF-MET human PTPR tyrosine kinases Wnt signaling ZNRF3
Kim M, Reinhard C, Niehrs C. Elife. 2021 Sep 30;10:e70885. doi: 10.7554/eLife.70885.
PMID: 34590584
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Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

chromosome alignment Dishevelled Kinesin-13 Mitosis Wnt signaling

Bufe A, García Del Arco A, Hennecke M, de Jaime-Soguero A, Ostermaier M, Lin YC, Ciprianidis A, Hattemer J, Engel U, Beli P, Bastians H, Acebrón SP. Proc Natl Acad Sci U S A. 2021 Aug 24; 118(34):e2108145118. doi:10.1073/pnas.2108145118.

PMID: 34417301

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Research Article

RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia

acute myeloid leukemia BMP drug resistance HSPC leukemia stem cell macrophages monocytes R-spondin self-renewal Wnt signaling
Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C, Niehrs C. Cell Rep. 2021 Aug 17;36(7):109559. doi: 10.1016/j.celrep.2021.109559.
PMID: 34407399
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Research Article

The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra

Astacin Axis formation Hydra Proteinase Wnt signaling
Ziegler B, Yiallouros I, Trageser B, Kumar S, Mercker M, Kling S, Fath M, Warnken U, Schnölzer M, Holstein TW, Hartl M, Marciniak-Czochra A, Stetefeld J, Stöcker W, Özbek S. BMC Biol. 2021 Jun 9;19(1):120. 
PMID: 34107975
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