{"id":8627,"date":"2022-01-31T17:46:08","date_gmt":"2022-01-31T16:46:08","guid":{"rendered":"https:\/\/sfb1324.de\/project\/a02\/"},"modified":"2026-01-27T15:13:26","modified_gmt":"2026-01-27T14:13:26","slug":"a02","status":"publish","type":"projects","link":"https:\/\/sfb1324.de\/de\/project\/a02\/","title":{"rendered":"A02"},"content":{"rendered":"\n

Das Konzept der vaskul\u00e4ren Kontrolle der Organfunktion (\u201eangiokrine Signal\u00fcbertragung\u201c) ist gut etabliert, wobei die Leber eine Modellfunktion einnimmt. Wir ermittelten, dass (i) endotheliale Wnt-Signale Hom\u00f6ostase und Anpassungsprozesse mechanosensitiv \u00fcber autokrine und angiokrine Wege steuern, (ii) hepatische Sternzellen Rspo3 sezernieren und damit perikrin Leberzonierung, -gr\u00f6\u00dfe und -funktion regulieren, und (iii) vaskul\u00e4re Wnt-Signale pathologische Prozesse wie die Metastasierung regulieren. Aufbauend auf diesen Erkenntnissen wird Projekt A02 in der dritten F\u00f6rderperiode die Funktionen angiokriner und perikriner Wnt-Signale in Leber und Lunge unter physiologischen und pathologischen Bedingungen untersuchen.<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Das Konzept der vaskul\u00e4ren Kontrolle der Organfunktion (\u201eangiokrine Signal\u00fcbertragung\u201c) ist gut etabliert, wobei die Leber eine Modellfunktion einnimmt. Wir ermittelten, dass (i) endotheliale Wnt-Signale Hom\u00f6ostase und Anpassungsprozesse mechanosensitiv \u00fcber autokrine und angiokrine Wege steuern, (ii) hepatische Sternzellen Rspo3 sezernieren und damit perikrin Leberzonierung, -gr\u00f6\u00dfe und -funktion regulieren, und (iii) vaskul\u00e4re Wnt-Signale pathologische Prozesse wie die … Weiterlesen<\/a><\/p>\n","protected":false},"featured_media":8107,"template":"","project-type":[2951],"class_list":["post-8627","projects","type-projects","status-publish","has-post-thumbnail","hentry","project-type-a-de"],"acf":[],"yoast_head":"\nA02 - SFB1324<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfb1324.de\/de\/project\/a02\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A02 - SFB1324\" \/>\n<meta property=\"og:description\" content=\"Das Konzept der vaskul\u00e4ren Kontrolle der Organfunktion (\u201eangiokrine Signal\u00fcbertragung\u201c) ist gut etabliert, wobei die Leber eine Modellfunktion einnimmt. Wir ermittelten, dass (i) endotheliale Wnt-Signale Hom\u00f6ostase und Anpassungsprozesse mechanosensitiv \u00fcber autokrine und angiokrine Wege steuern, (ii) hepatische Sternzellen Rspo3 sezernieren und damit perikrin Leberzonierung, -gr\u00f6\u00dfe und -funktion regulieren, und (iii) vaskul\u00e4re Wnt-Signale pathologische Prozesse wie die … Weiterlesen\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sfb1324.de\/de\/project\/a02\/\" \/>\n<meta property=\"og:site_name\" content=\"SFB1324\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-27T14:13:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sfb1324.de\/wp-content\/uploads\/2022\/01\/A02_liver.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1067\" \/>\n\t<meta property=\"og:image:height\" content=\"1067\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sfb1324.de\\\/de\\\/project\\\/a02\\\/\",\"url\":\"https:\\\/\\\/sfb1324.de\\\/de\\\/project\\\/a02\\\/\",\"name\":\"A02 - SFB1324\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sfb1324.de\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sfb1324.de\\\/de\\\/project\\\/a02\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sfb1324.de\\\/de\\\/project\\\/a02\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/i0.wp.com\\\/sfb1324.de\\\/wp-content\\\/uploads\\\/2022\\\/01\\\/A02_liver.jpg?fit=1067%2C1067&ssl=1\",\"datePublished\":\"2022-01-31T16:46:08+00:00\",\"dateModified\":\"2026-01-27T14:13:26+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sfb1324.de\\\/de\\\/project\\\/a02\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sfb1324.de\\\/de\\\/project\\\/a02\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/sfb1324.de\\\/de\\\/project\\\/a02\\\/#primaryimage\",\"url\":\"https:\\\/\\\/i0.wp.com\\\/sfb1324.de\\\/wp-content\\\/uploads\\\/2022\\\/01\\\/A02_liver.jpg?fit=1067%2C1067&ssl=1\",\"contentUrl\":\"https:\\\/\\\/i0.wp.com\\\/sfb1324.de\\\/wp-content\\\/uploads\\\/2022\\\/01\\\/A02_liver.jpg?fit=1067%2C1067&ssl=1\",\"width\":1067,\"height\":1067},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sfb1324.de\\\/de\\\/project\\\/a02\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sfb1324.de\\\/de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Projects\",\"item\":\"https:\\\/\\\/sfb1324.de\\\/project\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"A02\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sfb1324.de\\\/#website\",\"url\":\"https:\\\/\\\/sfb1324.de\\\/\",\"name\":\"SFB1324\",\"description\":\"Mechanisms and functions of Wnt signaling\",\"publisher\":{\"@id\":\"https:\\\/\\\/sfb1324.de\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sfb1324.de\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/sfb1324.de\\\/#organization\",\"name\":\"SFB1324\",\"url\":\"https:\\\/\\\/sfb1324.de\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/sfb1324.de\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"SFB1324\"},\"image\":{\"@id\":\"https:\\\/\\\/sfb1324.de\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A02 - SFB1324","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sfb1324.de\/de\/project\/a02\/","og_locale":"de_DE","og_type":"article","og_title":"A02 - SFB1324","og_description":"Das Konzept der vaskul\u00e4ren Kontrolle der Organfunktion (\u201eangiokrine Signal\u00fcbertragung\u201c) ist gut etabliert, wobei die Leber eine Modellfunktion einnimmt. 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