{"id":8697,"date":"2022-01-31T17:57:01","date_gmt":"2022-01-31T16:57:01","guid":{"rendered":"https:\/\/sfb1324.de\/project\/b06\/"},"modified":"2026-01-27T15:24:53","modified_gmt":"2026-01-27T14:24:53","slug":"b06","status":"publish","type":"projects","link":"https:\/\/sfb1324.de\/de\/project\/b06\/","title":{"rendered":"B06"},"content":{"rendered":"\n

Unsere Arbeiten zeigen, dass der tiefe Ruhezustand gesunder neuraler Stammzellen mit hoher kanonischer WNT-Aktivit\u00e4t verkn\u00fcpft ist und durch ein spezifisches DNA-Methylom aufrechterhalten wird. Beim Austritt aus dieser Quieszenz remodellieren die Zellen ihr Methylom und exprimieren die WNT-Antagonisten sFRP1 und Notum. In malignen Glioblastomzellen bewirkt eine erzwungene sFRP1-Expression ebenfalls Methylom-Remodelling, versetzt die Zellen in tiefe Quieszenz und verl\u00e4ngert das \u00dcberleben in pr\u00e4klinischen Modellen. Unklar bleibt jedoch, ob Tumore diese sFRP1-induzierte Ruhe durch Selbst-Erneuerung kompensieren, wie stabil der Zustand ist und ob der Effekt der WNT-Modulation vom Tumorort im Gehirn abh\u00e4ngt.<\/p>\n","protected":false},"excerpt":{"rendered":"

Unsere Arbeiten zeigen, dass der tiefe Ruhezustand gesunder neuraler Stammzellen mit hoher kanonischer WNT-Aktivit\u00e4t verkn\u00fcpft ist und durch ein spezifisches DNA-Methylom aufrechterhalten wird. Beim Austritt aus dieser Quieszenz remodellieren die Zellen ihr Methylom und exprimieren die WNT-Antagonisten sFRP1 und Notum. In malignen Glioblastomzellen bewirkt eine erzwungene sFRP1-Expression ebenfalls Methylom-Remodelling, versetzt die Zellen in tiefe Quieszenz … Weiterlesen<\/a><\/p>\n","protected":false},"featured_media":8090,"template":"","project-type":[2952],"class_list":["post-8697","projects","type-projects","status-publish","has-post-thumbnail","hentry","project-type-b-de"],"acf":[],"yoast_head":"\nB06 - SFB1324<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfb1324.de\/de\/project\/b06\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"B06 - SFB1324\" \/>\n<meta property=\"og:description\" content=\"Unsere Arbeiten zeigen, dass der tiefe Ruhezustand gesunder neuraler Stammzellen mit hoher kanonischer WNT-Aktivit\u00e4t verkn\u00fcpft ist und durch ein spezifisches DNA-Methylom aufrechterhalten wird. 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