{"id":8704,"date":"2022-01-31T17:58:34","date_gmt":"2022-01-31T16:58:34","guid":{"rendered":"https:\/\/sfb1324.de\/project\/b08\/"},"modified":"2026-01-27T15:27:06","modified_gmt":"2026-01-27T14:27:06","slug":"b08","status":"publish","type":"projects","link":"https:\/\/sfb1324.de\/de\/project\/b08\/","title":{"rendered":"B08"},"content":{"rendered":"\n

Der Wnt- und Ras-Signalweg sind beim kolorektalen Karzinom eng miteinander verbunden. Sie f\u00f6rdern gemeinsam die Karzinogenese des kolorektalen Karzinoms und Ph\u00e4notypen von fortgeschrittenen Tumoren. Wir konnten zeigen, dass die Hemmung von MEK1\/2 den Wnt-Signalweg in Modellen des kolorektalen Karzinoms stimuliert. Als zugrunde liegenden Mechanismus haben wir einen Verlust von AXIN1 identifiziert, der durch kombinierte Repression der Transkription und Translation des Gens verursacht wird. Wir werden den Fokus nun auf pan-KRAS Inhibitor vermittelte Stimulation des Wnt-Signalwegs ausweiten, um gemeinsame und unterschiedliche Mechanismen der Aktivierung im Vergleich zu MEK1\/2-Inhibitoren zu identifizieren.<\/p>\n","protected":false},"excerpt":{"rendered":"

Der Wnt- und Ras-Signalweg sind beim kolorektalen Karzinom eng miteinander verbunden. Sie f\u00f6rdern gemeinsam die Karzinogenese des kolorektalen Karzinoms und Ph\u00e4notypen von fortgeschrittenen Tumoren. Wir konnten zeigen, dass die Hemmung von MEK1\/2 den Wnt-Signalweg in Modellen des kolorektalen Karzinoms stimuliert. Als zugrunde liegenden Mechanismus haben wir einen Verlust von AXIN1 identifiziert, der durch kombinierte Repression … Weiterlesen<\/a><\/p>\n","protected":false},"featured_media":8086,"template":"","project-type":[2952],"class_list":["post-8704","projects","type-projects","status-publish","has-post-thumbnail","hentry","project-type-b-de"],"acf":[],"yoast_head":"\nB08 - SFB1324<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sfb1324.de\/de\/project\/b08\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"B08 - SFB1324\" \/>\n<meta property=\"og:description\" content=\"Der Wnt- und Ras-Signalweg sind beim kolorektalen Karzinom eng miteinander verbunden. 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