LRPs in WNT Signalling

DKK therapeutic antibodies LRP LRP4 LRP5 LRP5 disease mutations LRP6 LRP6 disease mutations LRP6 structure Sclerostin therapeutic antibodies Wnt Wnt co-receptor Wnt surrogates

Davidson G. Handb Exp Pharmacol. 2021;269:45-73. doi: 10.1007/164_2021_526. PMID: 34490514


Learn more
Research Article

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

cell biology developmental biology human LRP6 PTPRK spemann organizer tyrosine phosphatase Wnt signaling xenopus ZNRF3

Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. Elife. 2020 Jan 14;9. pii: e51248.

PMID: 31934854

Learn more