Publication Tag: R-spondin

Research Article

ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

lysosome LYTAC PD-L1 PROTAC protein degradation R-spondin RNF43 transmembrane E3 ligase ZNRF3
Sun R, Meng Z, Lee H, Offringa R, Niehrs C. Cell Chem Biol. 2023 Jun 8:S2451-9456(23)00153-8. doi: 10.1016/j.chembiol.2023.05.010. Online ahead of print. PMID: 37321224
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Research Article

RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia

acute myeloid leukemia BMP drug resistance HSPC leukemia stem cell macrophages monocytes R-spondin self-renewal Wnt signaling
Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C, Niehrs C. Cell Rep. 2021 Aug 17;36(7):109559. doi: 10.1016/j.celrep.2021.109559.
PMID: 34407399
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Research Article

R-spondins are BMP receptor antagonists in Xenopus early embryonic development

BMP signaling embryonic development R-spondin Wnt signaling

Lee H, Seidl C, Sun R, Glinka A, Niehrs C. Nat Commun. 2020 Nov 4;11(1):5570. 

PMID: 33149137

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