Research Article

Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates

biomolecular condensates CRISPR Dishevelled superresolution microscopy Wnt signaling

Schubert A, Voloshanenko O, Ragaller F, Gmach P, Kranz D, Scheeder C, Miersch T, Schulz M, Trümper L, Binder C, Lampe M, Engel U, Boutros M. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122476119. doi: 10.1073/pnas.2122476119. Epub 2022 Jul 22. PMID: 35867833

Learn more
Review

The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling.

Axis formation Gradients Hydra Nematostella Nodal signaling Tgf-beta signaling Wnt signaling

Holstein TW. Dev Biol. 2022 Apr 22;487:74-98. doi: 10.1016/j.ydbio.2022.04.005. Online ahead of print.

PMID: 35461834

Learn more
Research Article

Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd

AML BMP4 signaling cell differentiation dendrimer development peptides R-spondin2 TSP1 Wnt signaling xenopus
Lee H, Sun R, Niehrs C. J Biol Chem. 2022 Jan 12:101586. doi: 10.1016/j.jbc.2022.101586. Online ahead of print.
PMID: 35032551
Learn more
Research Article

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

cancer cell biology CRISPR ctnnb1 endogenous tagging FCS fluorescence correlation spectroscopy genetics genomics human β-catenin oncogenic signaling Wnt signaling
Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11:e64498. doi: 10.7554/eLife.64498.
PMID: 35014953
Learn more
Review

The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation

Axis formation Wnt signaling xenopus

Niehrs C. Dev Biol. 2022 Feb;482:1-6. doi: 10.1016/j.ydbio.2021.11.006. Epub 2021 Nov 21. PMID: 34818531

Learn more
Research Article

A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

cell biology endocytosis HGF-MET human PTPR tyrosine kinases Wnt signaling ZNRF3
Kim M, Reinhard C, Niehrs C. Elife. 2021 Sep 30;10:e70885. doi: 10.7554/eLife.70885.
PMID: 34590584
Learn more
Research Article

Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

chromosome alignment Dishevelled Kinesin-13 Mitosis Wnt signaling

Bufe A, García Del Arco A, Hennecke M, de Jaime-Soguero A, Ostermaier M, Lin YC, Ciprianidis A, Hattemer J, Engel U, Beli P, Bastians H, Acebrón SP. Proc Natl Acad Sci U S A. 2021 Aug 24; 118(34):e2108145118. doi:10.1073/pnas.2108145118.

PMID: 34417301

Learn more
Research Article

RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia

acute myeloid leukemia BMP drug resistance HSPC leukemia stem cell macrophages monocytes R-spondin self-renewal Wnt signaling
Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C, Niehrs C. Cell Rep. 2021 Aug 17;36(7):109559. doi: 10.1016/j.celrep.2021.109559.
PMID: 34407399
Learn more
Research Article

The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra

Astacin Axis formation Hydra Proteinase Wnt signaling
Ziegler B, Yiallouros I, Trageser B, Kumar S, Mercker M, Kling S, Fath M, Warnken U, Schnölzer M, Holstein TW, Hartl M, Marciniak-Czochra A, Stetefeld J, Stöcker W, Özbek S. BMC Biol. 2021 Jun 9;19(1):120. 
PMID: 34107975
Learn more
Research Article

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

angiocrine factors liver endothelial cell (L-EC) phosphoproteomics proteomics Tie1 Tie2 transcriptomics vascular zonation Wnt signaling

Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Vélez PA, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG. Dev Cell. 2021 Jun 7;56(11):1677-1693.e10.

PMID: 34038707

Learn more