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A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

angiocrine factors liver endothelial cell (L-EC) phosphoproteomics proteomics Tie1 Tie2 transcriptomics vascular zonation Wnt signaling

Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Vélez PA, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG. Dev Cell. 2021 Jun 7;56(11):1677-1693.e10.

PMID: 34038707

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Research Article

Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments

Frizzled NanoBRET Wnt signaling

Kozielewicz P, Shekhani R, Moser S, Bowin CF, Wesslowski J, Davidson G, Schulte G. ACS Pharmacol Transl Sci. 2021 May 11;4(3):1235-1245. doi: 10.1021/acsptsci.1c00084. eCollection 2021 Jun 11.

PMID: 34151213

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Research Article

USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling

colorectal cancer deubiquitination EMT LGR4/5/6 mouse intestinal organoids. Wnt signaling
Giebel N, de Jaime-Soguero A, García Del Arco A, Landry JJM, Tietje M, Villacorta L, Benes V, Fernández-Sáiz V, Acebrón SP. EMBO Rep. 2021 Mar 30:e51415. doi: 10.15252/embr.202051415. Online ahead of print.
PMID: 33786993
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Research Article

Wnt10b GSK3β dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

chromosome stability GSK3β Mitosis Wnt signaling Wnt/STOP Wnt10b
Lin YC, Haas A, Bufe A, Parbin S, Hennecke M, Voloshanenko O, Gross J, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2020 Nov 30;4(1):e202000855. Print 2021 Jan.
PMID: 33257473
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Research Article

R-spondins are BMP receptor antagonists in Xenopus early embryonic development

BMP signaling embryonic development R-spondin Wnt signaling

Lee H, Seidl C, Sun R, Glinka A, Niehrs C. Nat Commun. 2020 Nov 4;11(1):5570. 

PMID: 33149137

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Research Article

The kinesin motor Klp98A mediates apical to basal Wg transport

endosomal trafficking kinesin transport transcytosis Wnt secretion Wnt signaling
Witte L, Linnemannstöns K, Schmidt K, Honemann-Capito M, Grawe F, Wodarz A, Gross JC. Development. 2020 Aug 14;147(15):dev186833. doi: 10.1242/dev.186833.
PMID: 32665246
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Research Article

Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium

endosomal sorting morphogen trafficking Wnt secretion Wnt signaling

Linnemannstöns K, Witte L, Karuna P, Kittel J, Danieli A, Müller D, Nitsch L, Honemann-Capito M, Grawe F, Wodarz A, Gross JC. Development. 2020 Aug 14;147(15):dev185421. PMID: 32611603

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Research Article

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

bioluminescence resonance energy transfer (BRET) Frizzled fusion protein G protein–coupled receptor (GPCR) ligand binding membrane protein NanoBiT NanoBRET trafficking Wnt signaling

Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G. J Biol Chem. 2020 May 7. pii: jbc.RA120.012892.

PMID:32381507

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Research Article

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

cell biology developmental biology human LRP6 PTPRK spemann organizer tyrosine phosphatase Wnt signaling xenopus ZNRF3

Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. Elife. 2020 Jan 14;9. pii: e51248.

PMID: 31934854

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Research Article

Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium

Drosophila polarized epithelium Wg Wnt secretion Wnt signaling

Chaudhary V, Boutros M. PLoS Genet. 2019 Sep 17;15(9):e1008351.

PMID: 31527874

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