Review

The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling.

Axis formation Gradients Hydra Nematostella Nodal signaling Tgf-beta signaling Wnt signaling

Holstein TW. Dev Biol. 2022 Apr 22;487:74-98. doi: 10.1016/j.ydbio.2022.04.005. Online ahead of print.

PMID: 35461834

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Review

Cross-Talk between p53 and Wnt Signaling in Cancer

APC beta-catenin cancer drug resistance metastasis p53 Wnt

Xiao Q, Werner J, Venkatachalam N, Boonekamp KE, Ebert MP, Zhan T. Biomolecules. 2022 Mar 15;12(3):453. doi: 10.3390/biom12030453. PMID: 35327645

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Research Article

Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd

AML BMP4 signaling cell differentiation dendrimer development peptides R-spondin2 TSP1 Wnt signaling xenopus
Lee H, Sun R, Niehrs C. J Biol Chem. 2022 Jan 12:101586. doi: 10.1016/j.jbc.2022.101586. Online ahead of print.
PMID: 35032551
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Research Article

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

cancer cell biology CRISPR ctnnb1 endogenous tagging FCS fluorescence correlation spectroscopy genetics genomics human β-catenin oncogenic signaling Wnt signaling
Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11:e64498. doi: 10.7554/eLife.64498.
PMID: 35014953
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Research Article

Two plus one is almost three: a fast approximation for multi-view deconvolution

3D imaging; Hydra light sheet fluorescence microscopy zebrafish

Hüpfel M, Fernández Merino M, Bennemann J, Takamiya M, Rastegar S, Tursch A, Holstein TW, Nienhaus GU. Biomed Opt Express. 2021 Dec 7;13(1):147-158. doi: 10.1364/BOE.443660. eCollection 2022 Jan 1. PMID: 35154860

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Other

The molecular logic of synaptic wiring at the single cell level

Velten, J., R. Agarwal, P. van Nierop y Sanchez, L. Bognar, M. Paulsen, L. Velten, and I. Lohmann. 2021. bioRxiv, preprint.

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Review

The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation

Axis formation Wnt signaling xenopus

Niehrs C. Dev Biol. 2022 Feb;482:1-6. doi: 10.1016/j.ydbio.2021.11.006. Epub 2021 Nov 21. PMID: 34818531

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Research Article

A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

cell biology endocytosis HGF-MET human PTPR tyrosine kinases Wnt signaling ZNRF3
Kim M, Reinhard C, Niehrs C. Elife. 2021 Sep 30;10:e70885. doi: 10.7554/eLife.70885.
PMID: 34590584
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Review

LRPs in WNT Signalling

DKK therapeutic antibodies LRP LRP4 LRP5 LRP5 disease mutations LRP6 LRP6 disease mutations LRP6 structure Sclerostin therapeutic antibodies Wnt Wnt co-receptor Wnt surrogates

Davidson G. (2021) LRPs in WNT Signalling. In: Schulte G., Kozielewicz P. (eds) Pharmacology of the WNT Signaling System. Handbook of Experimental Pharmacology, vol 269. Springer, Cham.

 

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Research Article

Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

chromosome alignment Dishevelled Kinesin-13 Mitosis Wnt signaling

Bufe A, García Del Arco A, Hennecke M, de Jaime-Soguero A, Ostermaier M, Lin YC, Ciprianidis A, Hattemer J, Engel U, Beli P, Bastians H, Acebrón SP. Proc Natl Acad Sci U S A. 2021 Aug 24; 118(34):e2108145118. doi:10.1073/pnas.2108145118.

PMID: 34417301

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