Prof. Dr. Holger Bastians

Project Leader B03

Department of Molecular Oncology
University Medical Center Göttingen
Georg-August University Göttingen

holger.bastians@uni-goettingen.de

http://www.moloncol.med.uni-goettingen.de/de/content/researchgroups/101.html

Beruflicher Werdegang

since 2013

Head of Section Cellular Oncology

University Medical Center Göttingen

2011-2013

Heisenberg Professor of the DFG

University Medical Center Göttingen, Germany

2010-2011

Heisenberg fellow of the DFG and Group leader

Institute of Molecular Oncology, University Medical Center Göttingen

2008-2010

Heisenberg fellow of the DFG and Group leader

Institute for Molecular Biology and Tumor Research (IMT), Phillips-University Marburg

2006

Habilitation

Molecular Biology, Phillips-University Marburg

1999-2008

Group leader

Institute for Molecular Biology and Tumor Research (IMT), Phillips-University Marburg

1996-1999

Postdoctoral Researcher

Prof. Joan Ruderman, Department of Cell Biology, Harvard Medical School, Boston, USA

1996

Dr. rer. nat

Topic: cell cycle regulation; German Cancer Research Center, Heidelberg and University of Osnabrück

1993

Diploma in Biology

University of Osnabrück

Erfolge & Auszeichnungen

2025

Prize for the best patent filing

Georg-August University Göttingen

since 2019

Spokesperson

DFG research unit 2800 (FOR2800)

2015

Binder Innovation Prize

German Society for Cell Biology

2014

Paper of the year Award

University Medical Center Göttingen

2011 - 2013

Heisenberg professorship

DFG

2008-2011

Heisenberg fellowship

DFG

1996-1999

Research fellowship

DFG

Publikationen

Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer

Haas A, Wenz F, Hattemer J, Wesslowski J, Davidson G, Voloshanenko O, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2025 Aug 22;8(11):e202503295. doi: 10.26508/lsa.202503295. Print 2025 Nov. PMID: 40846632

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Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress

de Jaime-Soguero A, Hattemer J, Bufe A, Haas A, van den Berg J, van Batenburg V, Das B, di Marco B, Androulaki S, Böhly N, Landry JJM, Schoell B, Rosa VS, Villacorta L, Baskan Y, Trapp M, Benes V, Chabes A, Shahbazi M, Jauch A, Engel U, Patrizi A, Sotillo R, van Oudenaarden A, Bageritz J, Alfonso J, Bastians H, Acebrón SP. Nat Commun. 2024 Aug 28;15(1):7404. doi: 10.1038/s41467-024-51821-9. PMID: 39191776

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Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

Bufe A, García Del Arco A, Hennecke M, de Jaime-Soguero A, Ostermaier M, Lin YC, Ciprianidis A, Hattemer J, Engel U, Beli P, Bastians H, Acebrón SP. Proc Natl Acad Sci U S A. 2021 Aug 24; 118(34):e2108145118. doi:10.1073/pnas.2108145118. PMID: 34417301

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Wnt10b GSK3β dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

Lin YC, Haas A, Bufe A, Parbin S, Hennecke M, Voloshanenko O, Gross J, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2020 Nov 30;4(1):e202000855. Print 2021 Jan.
PMID: 33257473

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The p53/p73 – p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells

Schmidt AK, Pudelko K, Boekenkamp JE, Berger K, Kschischo M, Bastians H. Oncogene. 2021 Jan;40(2):436-451. doi: 10.1038/s41388-020-01524-4. Epub 2020 Nov 9. PMID: 33168930

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Mild replication stress causes aneuploidy by deregulating microtubule dynamics in mitosis

Böhly N, Kistner M, Bastians H. Cell Cycle. 2019 Oct;18(20):2770-2783. doi: 10.1080/15384101.2019.1658477. Epub 2019 Aug 25. PMID: 31448675

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A Cell-Based Assay for Mitotic Spindle Orientation

Glaubke E, Bastians H. Methods Mol Biol. 2018;1787:67-75. doi: 10.1007/978-1-4939-7847-2_5. PMID:29736710

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Wnt-mediated protein stabilization ensures proper mitotic microtubule assembly and chromosome segregation

Stolz A, Neufeld K, Ertych N, Bastians H. EMBO Rep. 2015 Apr;16(4):490-9. doi: 10.15252/embr.201439410. Epub 2015 Feb 5. PMID: 25656539

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Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.

Ertych N, Stolz A, Stenzinger A, Weichert W, Kaulfuß S, Burfeind P, Aigner A, Wordeman L, Bastians H. Nat Cell Biol. 2014 Aug;16(8):779-91. doi: 10.1038/ncb2994. Epub 2014 Jun 29. PMID: 24976383

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