CRC 1324: Mechanisms and functions of Wnt signaling

Welcome to the website of the Collaborative Research Center (CRC) 1324 from Heidelberg University.

Who we are

The Collaborative Research Center 1324 is a DFG-funded interdisciplinary research consortium of about 60 scientists in 15 projects and three technology platforms. Our research focuses on the mechanisms and functions of Wnt signaling.



Wnt Seminar

Rene Jackstadt (DKFZ and HI-STEM gGmbH, Heidelberg)
Project A06 (Davidson/Nienhaus)

Learn more


Research Article

DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2

Fatti E, Hirth A, Švorinić A, Günther M, Stier G, Cruciat CM, Acebrón SP, Papageorgiou D, Sinning I, Krijgsveld J, Höfer T, Niehrs C. Sci Signal. 2023 Apr 25;16(782):eabp8923. doi: 10.1126/scisignal.abp8923. Epub 2023 Apr 25. PMID: 37098120
Learn more
Research Article

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model

binding affinity shift CRISPR/Cas9 FZD7 NanoBiT/BRET binding SW480 cells Wnt
Grätz L, Sajkowska-Kozielewicz JJ, Wesslowski J, Kinsolving J, Bridge LJ, Petzold K, Davidson G, Schulte G, Kozielewicz P. Br J Pharmacol. 2023 Apr 13. doi: 10.1111/bph.16090. Online ahead of print. PMID: 37055379
Learn more

Join the CRC 1324

Wnt Young Investigator program

We are searching for exceptional early career scientists with a research interest in Wnt signaling to apply for independent junior group funding.

Further information can be found here: Wnt_YIP

Application deadline September 01, 2022

Herbert Steinbeisser Fellowships

In memory of Professor Dr. Herbert Steinbeisser, the SFB1324 offers fellowships to support medical students during experimental research projects that comprise part of their M.D. thesis. Further information can be found here: SFB1324 Herbert Steinbeisser Fellowships

Applications can be submitted twice annually, by June 15th and December 15th.


ERC Synergy Grant

Anna Marciniak-Czochra and Ana Martin-Villalba together with Simon Anders (Heidelberg University) and Laure Bally-Cuif (Institut Pasteur in Paris) received an ERC Synergy Grant.

Learn more

Follow us on

Tweets about latest publications, announcements and events on #Wnt signaling.

Twitter feed is not available at the moment.