CRC 1324: Mechanisms and functions of Wnt signaling

Welcome to the website of the Collaborative Research Center (CRC) 1324 from Heidelberg University.

Who we are

The Collaborative Research Center 1324 is a DFG-funded interdisciplinary research consortium of about 60 scientists in 15 projects and three technology platforms. Our research focuses on the mechanisms and functions of Wnt signaling.



Wnt Seminar

Project A04: Britta Brügger
Project B02: Alexander Aulehla

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Wnt Workshop 2023

March 17th 2023
Marsilius Kolleg

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Research Article

Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response

inflammation monocytes myocardial infarction Wnt signaling
Meyer IS, Li X, Meyer C, Voloshanenko O, Pohl S, Boutros M, Katus HA, Frey N, Leuschner F. Int J Mol Sci. 2022 Oct 14;23(20):12252. doi: 10.3390/ijms232012252.
PMID: 36293109
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Research Article

Injury-induced MAPK activation triggers body axis formation in Hydra by default Wnt signaling

Axis formation injury response MAPK signaling regeneration Wnt/beta-catenin
Tursch A, Bartsch N, Mercker M, Schlüter J, Lommel M, Marciniak-Czochra A, Özbek S, Holstein TW. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2204122119. doi: 10.1073/pnas.2204122119. Epub 2022 Aug 22. PMID: 35994642
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Join the CRC 1324

Wnt Young Investigator program

We are searching for exceptional early career scientists with a research interest in Wnt signaling to apply for independent junior group funding.

Further information can be found here: Wnt_YIP

Application deadline September 01, 2022

Herbert Steinbeisser Fellowships

In memory of Professor Dr. Herbert Steinbeisser, the SFB1324 offers fellowships to support medical students during experimental research projects that comprise part of their M.D. thesis. Further information can be found here: SFB1324 Herbert Steinbeisser Fellowships

Applications can be submitted twice annually, by June 15th and December 15th.


ERC Synergy Grant

Anna Marciniak-Czochra and Ana Martin-Villalba together with Simon Anders (Heidelberg University) and Laure Bally-Cuif (Institut Pasteur in Paris) received an ERC Synergy Grant.

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Follow us on

Tweets about latest publications, announcements and events on #Wnt signaling.

bioRxiv_Wnt_Feed: Counterintuitive Binding of Phosphorylated DEP Domain from Dishevelled Protein to Negatively Charged Membranes

bioRxiv_Wnt_Feed: Haploid androgenetic development in bovines reveals imbalanced WNT signaling and impaired cell fate differentiation.