Publications

Research Article

A temperature-tolerant CRISPR base editor mediates highly efficient and precise gene editing in Drosophila

Doll RM, Boutros M, Port F. Sci Adv. 2023 Sep;9(35):eadj1568. doi: 10.1126/sciadv.adj1568. Epub 2023 Aug 30. PMID: 37647411

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Research Article

Glyoxal as alternative fixative for single cell RNA sequencing

cell fixation glyoxal single cell RNA sequencing transcriptomics
Bageritz J, Krausse N, Yousefian S, Leible S, Valentini E, Boutros M. G3 (Bethesda). 2023 Jul 26:jkad160. doi: 10.1093/g3journal/jkad160. Online ahead of print. PMID: 37494060
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Research Article

ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

lysosome LYTAC PD-L1 PROTAC protein degradation R-spondin RNF43 transmembrane E3 ligase ZNRF3
Sun R, Meng Z, Lee H, Offringa R, Niehrs C. Cell Chem Biol. 2023 Jun 8:S2451-9456(23)00153-8. doi: 10.1016/j.chembiol.2023.05.010. Online ahead of print. PMID: 37321224
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Research Article

DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2

Fatti E, Hirth A, Švorinić A, Günther M, Stier G, Cruciat CM, Acebrón SP, Papageorgiou D, Sinning I, Krijgsveld J, Höfer T, Niehrs C. Sci Signal. 2023 Apr 25;16(782):eabp8923. doi: 10.1126/scisignal.abp8923. Epub 2023 Apr 25. PMID: 37098120
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Research Article

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model

binding affinity shift CRISPR/Cas9 FZD7 NanoBiT/BRET binding SW480 cells Wnt
Grätz L, Sajkowska-Kozielewicz JJ, Wesslowski J, Kinsolving J, Bridge LJ, Petzold K, Davidson G, Schulte G, Kozielewicz P. Br J Pharmacol. 2023 Apr 13. doi: 10.1111/bph.16090. Online ahead of print. PMID: 37055379
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Research Article

Wnt/β-catenin signaling induces axial elasticity patterns of Hydra extracellular matrix

Histology Microscopic anatomy Molecular biology Zoology
Veschgini M, Suzuki R, Kling S, Petersen HO, Bergheim BG, Abuillan W, Linke P, Kaufmann S, Burghammer M, Engel U, Stein F, Özbek S, Holstein TW, Tanaka M. iScience. 2023 Mar 16;26(4):106416. doi: 10.1016/j.isci.2023.106416. eCollection 2023 Apr 21. PMID: 37009232
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Research Article

N-Glycosylation of LRP6 by B3GnT2 Promotes Wnt/β-Catenin Signalling

B3GnT2 glycosylation LRP6 polylactosamine Wnt signalling Wnt/β-catenin
Xu R, Wang X, Safi S, Braunegger N, Hipgrave Ederveen A, Rottmann M, Wittbrodt J, Wuhrer M, Wesslowski J, Davidson G. Cells. 2023 Mar 10;12(6):863. doi: 10.3390/cells12060863. PMID: 36980204
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Review

The Roles of Secreted Wnt Ligands in Cancer

cancer immunotherapy metastasis non-canonical Wnt signaling targeted therapy tumor microenvironment Wnt ligands Wnt signaling

Werner J, Boonekamp KE, Zhan T, Boutros M. Int J Mol Sci. 2023 Mar 10;24(6):5349. doi: 10.3390/ijms24065349. PMID: 36982422

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Research Article

Mucociliary Wnt signaling promotes cilia biogenesis and beating

Cell signalling Ciliogenesis Wnt

Seidl C, Da Silva F, Zhang K, Wohlgemuth K, Omran H, Niehrs C. Nat Commun. 2023 Mar 6;14(1):1259. doi: 10.1038/s41467-023-36743-2. PMID: 36878953

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Review

The role of Evi/Wntless in exporting Wnt proteins

cancer development Evi PORCN/Porcupine Wnt secretion Wnt signaling Wntless/Wls
Wolf L, Boutros M. Development. 2023 Feb 15;150(3):dev201352. doi: 10.1242/dev.201352. Epub 2023 Feb 10.
PMID: 36763105
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Review

From injury to patterning-MAPKs and Wnt signaling in Hydra

Axis formation injury response MAPK signaling Pattern formation regeneration Wnt/β-catenin
Tursch A, Holstein TW. Curr Top Dev Biol. 2023;153:381-417. doi: 10.1016/bs.ctdb.2023.01.003. Epub 2023 Feb 9. PMID: 36967201 Review.
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Research Article

Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis

cilia exencephaly GSK3 lipodystrophy LRP6 PP1 Wnt
Zhang K, Da Silva F, Seidl C, Wilsch-Bräuninger M, Herbst J, Huttner WB, Niehrs C. Dev Cell. 2023 Jan 23;58(2):139-154.e8. doi: 10.1016/j.devcel.2022.12.006. PMID: 36693320
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