Research Article

Injury-induced MAPK activation triggers body axis formation in Hydra by default Wnt signaling

Axis formation injury response MAPK signaling regeneration Wnt/beta-catenin
Tursch A, Bartsch N, Mercker M, Schlüter J, Lommel M, Marciniak-Czochra A, Özbek S, Holstein TW. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2204122119. doi: 10.1073/pnas.2204122119. Epub 2022 Aug 22. PMID: 35994642
Learn more
Research Article

Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates

biomolecular condensates CRISPR Dishevelled superresolution microscopy Wnt signaling

Schubert A, Voloshanenko O, Ragaller F, Gmach P, Kranz D, Scheeder C, Miersch T, Schulz M, Trümper L, Binder C, Lampe M, Engel U, Boutros M. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122476119. doi: 10.1073/pnas.2122476119. Epub 2022 Jul 22. PMID: 35867833

Learn more
Review

Genetically encodable fluorescent protein markers in advanced optical imaging

fluorescence microscopy genetically encodable fluorescent markers GFP-type fluorescent protein super resolution microscopy tetrapyrrole-binding fluorescent protein
Nienhaus K, Nienhaus GU. Methods Appl Fluoresc. 2022 Jun 29. doi: 10.1088/2050-6120/ac7d3f. Online ahead of print.
PMID: 35767981
Learn more
Review

Wnt signalling in cell division: from mechanisms to tissue engineering

asymmetric cell division bioengineering chromosome segregation localised Wnt signalling Spindle orientation. stem cells

Habib SJ, Acebrón SP. Trends Cell Biol. 2022 Jun 15:S0962-8924(22)00137-4. doi: 10.1016/j.tcb.2022.05.006. Online ahead of print. PMID: 35717422

Learn more
Review

Cracking chromatin with proteomics: From chromatome to histone modifications

cell biology post-translational modification analysis sample preparation signal transduction technology

Sigismondo G, Papageorgiou DN, Krijgsveld J. Proteomics. 2022 May 28:e2100206. doi: 10.1002/pmic.202100206. Online ahead of print. PMID: 35633285

Learn more
Review

The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling.

Axis formation Gradients Hydra Nematostella Nodal signaling Tgf-beta signaling Wnt signaling

Holstein TW. Dev Biol. 2022 Apr 22;487:74-98. doi: 10.1016/j.ydbio.2022.04.005. Online ahead of print.

PMID: 35461834

Learn more
Review

Cross-Talk between p53 and Wnt Signaling in Cancer

APC beta-catenin cancer drug resistance metastasis p53 Wnt

Xiao Q, Werner J, Venkatachalam N, Boonekamp KE, Ebert MP, Zhan T. Biomolecules. 2022 Mar 15;12(3):453. doi: 10.3390/biom12030453. PMID: 35327645

Learn more
Research Article

Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd

AML BMP4 signaling cell differentiation dendrimer development peptides R-spondin2 TSP1 Wnt signaling xenopus
Lee H, Sun R, Niehrs C. J Biol Chem. 2022 Jan 12:101586. doi: 10.1016/j.jbc.2022.101586. Online ahead of print.
PMID: 35032551
Learn more
Research Article

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

cancer cell biology CRISPR ctnnb1 endogenous tagging FCS fluorescence correlation spectroscopy genetics genomics human β-catenin oncogenic signaling Wnt signaling
Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11:e64498. doi: 10.7554/eLife.64498.
PMID: 35014953
Learn more
Research Article

Two plus one is almost three: a fast approximation for multi-view deconvolution

3D imaging; Hydra light sheet fluorescence microscopy zebrafish

Hüpfel M, Fernández Merino M, Bennemann J, Takamiya M, Rastegar S, Tursch A, Holstein TW, Nienhaus GU. Biomed Opt Express. 2021 Dec 7;13(1):147-158. doi: 10.1364/BOE.443660. eCollection 2022 Jan 1. PMID: 35154860

Learn more
Review

Mitotic WNT: aligning chromosomes through KIF2A

Bufe A, Acebrón SP. Mol Cell Oncol. 2021 Dec 6;8(6):2011564. doi: 10.1080/23723556.2021.2011564. eCollection 2021. PMID: 35419471
Learn more
Review

The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation

Axis formation Wnt signaling xenopus

Niehrs C. Dev Biol. 2022 Feb;482:1-6. doi: 10.1016/j.ydbio.2021.11.006. Epub 2021 Nov 21. PMID: 34818531

Learn more