Publications

Research Article

Improved in vivo gene knockout with high specificity using multiplexed Cas12a sgRNAs

Port F, Buhmann MA, Zhou J, Stricker M, Vaughan-Brown A, Michalsen AC, Roßmanith E, Pöltl A, Großkurth L, Huber J, Menendez Kury LB, Weberbauer B, Hübl M, Puscher E, Heigwer F, Boutros M. Nat Commun. 2026 Jan 15;17(1):877. doi: 10.1038/s41467-026-68434-z.

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Research Article

Molecular dynamics of the matrisome across sea anemone life history

Cnidaria developmental biology evolutionary biology extracellular matrix matrisome nematostella vectensis sea anemone.

Bergheim BG, Cole AG, Rettel M, Stein F, Redl S, Hess MW, Ikmi A, Özbek S. Elife. 2025 Oct 23;14:RP105319. doi: 10.7554/eLife.105319.



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Research Article

    

      
Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium

    

    

          

    

      




Wünnemann F, Sicklinger F, Bestak K, Nimo J, Thiemann T, Amrute JM, Nordbeck M, Hartmann N, Ibarra-Arellano MA, Tanevski J, Chazotte M, Heine C, Frey N, Lavine KJ, Coscia F, Saez-Rodriguez J, Leuschner F, Schapiro D. Nat Cardiovasc Res. 2025 Oct;4(10):1345-1362. doi: 10.1038/s44161-025-00717-y. Epub 2025 Oct 3.






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Research Article

    

      
A noncanonical role of glycolytic metabolites controlling the timing of mouse embryo segmentation

    

    

          

    

      




Miyazawa H, Rada J, Prior N, Sanchez PGL, Esposito E, Bunina D, Girardot C, Zaugg J, Aulehla A. Sci Adv. 2025 Sep 19;11(38):eadz9606. doi: 10.1126/sciadv.adz9606. Epub 2025 Sep 19.






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Research Article

    

      
The interplay between Wnt and mTOR signaling modulates ciliogenesis in human retinal epithelial cells.

    

    

          

    

      
Yuan C, Neuner A, Streubel J, Bhanushali A, Simons M, Acebrón SP, Pereira G. PLoS Biol. 2025 Sep 2;23(9):e3003369. doi: 10.1371/journal.pbio.3003369. eCollection 2025 Sep. PMID: 40892854


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Research Article

    

      
Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer

    

    

          

    

      




Haas A, Wenz F, Hattemer J, Wesslowski J, Davidson G, Voloshanenko O, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2025 Aug 22;8(11):e202503295. doi: 10.26508/lsa.202503295. Print 2025 Nov. PMID: 40846632






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Research Article

    

      
CXCL4-Induced PBMCs Modulate Vascular Extracellular Matrix via Wnt5a-Dependent Matrix Metalloproteinase-7 and Calcifying Extracellular Vesicle Release

    

    

          

    

      




Krohn JB, Sprehe LK, Sicklinger F, Kawohl J, Hess C, Spieler A, Dihlmann S, Eis L, Gleissner CA, Katus HA, Frey N, Leuschner F. Arterioscler Thromb Vasc Biol. 2025 Oct;45(10):1799-1817. 


doi: 10.1161/ATVBAHA.124.322067. Epub 2025 Aug 21.






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Research Article

    

      
Combined MEK and PARP inhibition enhances radiation response in rectal cancer

    

    

            DNA repair
            drug combination screen
            MEK inhibitor
            organoids
            PARP inhibitor
            RAD51
            radiation therapy
            radiosensitizer
            RAS signaling
            rectal cancer.
          

    

      
Xiao Q, Riedesser JE, Mulholland T, Li Z, Buchloh J, Albrecht P, Yang X, Li M, Venkatachalam N, Skabkina O, Klupsch A, Eichhorn E, Wang L, Belle S, Schulte N, Schmitz D, Froelich MF, Trikhirhisthit K, Valentini E, Boonekamp KE, Petersen Y, Miersch T, Burgermeister E, Herskind C, Veldwijk MR, Brochhausen C, Ihnatko R, Krijgsveld J, Kurth I, Zhu Y, Ma Y, Cao K, Boutros M, Ebert MP, Zhan T, Betge J. Cell Rep Med. 2025 Aug 5:102284. doi: 10.1016/j.xcrm.2025.102284. Online ahead of print.


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Research Article

    

      
Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

    

    

            CNS cancer
            Computational biology and bioinformatics
            neural stem cells
          

    

      






Foerster LC, Kaya O, Wüst V, Danciu DP, Akcay V, Bekavac M, Ziegler KC, Stinchcombe N, Tang A, Kleber S, Tang J, Brunken J, Lois-Bermejo I, Gesteira-Perez N, Ma X, Sadik A, Le PU, Petrecca K, Opitz CA, Liu H, Wirtz CR, Goncalves A, Marciniak-Czochra A, Anders S, Martin-Villalba A. Nat Commun. 2025 Aug 6;16(1):7250. doi: 10.1038/s41467-025-62528-w.








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Research Article

    

      
Unraveling regulatory feedback mechanisms in adult neurogenesis through mathematical modelling

    

    

          

    

      
Danciu, DP., Klawe, F.Z., Kazarnikov, A., Femmer, L., Kostina, E., Martin-Villalba, A. and Marciniak-Czochra, A. Unraveling regulatory feedback mechanisms in adult neurogenesis through mathematical modelling. npj Syst Biol Appl 11, 82 (2025). doi:10.1038/s41540-025-00563-5


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Research Article

    

      
Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis

    

    

          

    

      
van Nierop Y Sanchez P, Sekhar PS, Yildirim K, Lange T, Kreplin LZ, Boopathy VM, Rosswag de Souza S, Dammer K, Ibberson D, Wang Q, Domsch K, Stokkermans A, Pandey S, Kaspar P, Martinez-Gallegos R, Gao X, Singh A, Engel N, Port F, Boutros M, Bageritz J, Lohmann I. Nat Commun. 2025 Jul 23;16(1):6766. doi: 10.1038/s41467-025-62046-9.


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Research Article

    

      
Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET.

    

    

            GFP-Wnt
            HiBiT
            HiBiT-FZD
            ligand–receptor binding
            LRP6
            NanoBiT/BRET
            Wnt signaling
            Wnt-FZD binding
          

    

      
Wesslowski J, Safi S, Rottmann M, Rothley M, Davidson G. Cells. 2025 May 30;14(11):810. doi: 10.3390/cells14110810.


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