The research program of our collaborative research center (CRC) 1324 consists of 15 projects and three technology platforms (projects Z) working on two research areas that are of key importance for advancing our understanding of molecular mechanisms governing Wnt signal transduction. In particular, the CRC 1324 focuses on two overarching topics:

Research focus A: Wnt secretion, trafficking and receptor-ligand interactions

• How are Wnt proteins produced, how are they modified and how are they transported in the extracellular space?
• How do Wnt ligand/receptor interactions specify the signaling response and induce different signaling cascades?

Research focus B: Wnt coupling to downstream and context-dependent signaling

• How is Wnt signaling activated and coupled to different downstream factors in a context-dependent manner?
• How are spatio-temporal dynamics of Wnt signaling controlled?

Projects and scientific concept of the CRC 1324

Projects A

Project A01


Mechanisms of Wnt protein secretion

Prof. Dr. Michael Boutros Prof. Dr. Irmgard Sinning
Project A02


Mechanisms of vascular Wnt signaling during liver homeostasis and tumorigenesis

Prof. Dr. Hellmut G. Augustin
Project A05


Roles of lipids in Wnt secretion and signaling

Prof. Dr. Britta Brügger Prof. Dr. Michael Boutros
Project A05


The Wnt code: Deciphering early Wnt interactions in Hydra

Prof. Dr. Thomas Holstein Prof. Dr. Motomu Tanaka
Project A06


Quantitative fluorescence microscopy for the analysis of Wnt pathway interactions and dynamics

Dr. Gary Davidson Prof. Dr. Gerd Ulrich Nienhaus
Project A07


Cell-specific activation of Wnt signaling in healing after myocardial infarction

Prof. Dr. med. Florian Leuschner
Project A08


Wnt pathway specificity in niche-stem cell control

Dr. Josephine Bageritz Prof. Dr. Ingrid Lohmann

Projects B

Project B01


Role of DDX56 in GSK3ß regulation during Wnt signaling

Prof. Dr. Christof Niehrs
Project B02


Mechanism of oscillatory Wnt signaling dynamics and its role in vertebrate embryos

Dr. Alexander Aulehla
Project B03


The roles of Wnt signaling in genome stability

Prof. Dr. Sergio P. Acebrón Prof. Dr. Holger Bastians
Project B05


Mathematical modeling of spatio-temporal dynamics of Wnt signaling and its function in development and regeneration

Prof. Dr. Anna Marciniak-Czochra
Project B06


Orchestration by the Wnt/Hippo/CD95 signalosome of stem- and EMT-like phenotypes

Prof. Dr. Ana Martin-Villalba
Project B07


Uncovering novel molecular mechanisms within Wnt signaling

Prof. Dr. Irmgard Sinning Apl. Prof. Dr. Suat Özbek
Project B08


Mechanism of AXIN1 degradation after MEK inhibition

Dr. med. Tianzuo Zhan
Project B09


Wnt-cilia signaling in epithelial polarization and renal development

Prof. Dr. Gislene Pereira Prof. Dr. med. Matias Simons

Projects Z


Central administration

Prof. Dr. Michael Boutros
Project Z02


Advanced fluorescence microscopy

Prof. Dr. Gerd Ulrich Nienhaus Dr. Ulrike Engel
Project Z03


Advanced genetic screens and genome engineering

Prof. Dr. Michael Boutros
Project Z04


Advanced Proteomics

Prof. Dr. Jeroen Krijgsveld

Projects (ended)

Project A03 ended


Ykt6-dependent trafficking of Wnts

Prof. Dr. Julia Gross
Project B04 ended


Wnt signaling in fate determination of retinal precursors

Prof. Dr. Joachim Wittbrodt