A01
Mechanisms of Wnt secretion in vivo
Prof. Dr. Michael Boutros
Projects
The research program for the third funding period of our collaborative research center (CRC) 1324 consists of 14 projects and three technology platforms (projects Z) working on two research areas that are of key importance for advancing our understanding of molecular mechanisms governing Wnt signal transduction. In particular, the CRC 1324 focuses on two overarching topics:
Research focus A: Wnt secretion, trafficking and receptor-ligand interactions
• How are Wnt proteins produced, how are they modified and how are they transported in the extracellular space?
• How do Wnt ligand/receptor interactions specify the signaling response and induce different signaling cascades?
Research focus B: Wnt coupling to downstream and context-dependent signaling
• How is Wnt signaling activated and coupled to different downstream factors in a context-dependent manner?
• How are spatio-temporal dynamics of Wnt signaling controlled?
Projects and scientific concept of the CRC 1324
Projects A
A02
Mechanisms of vascular Wnt signaling during liver and lung homeostasis and tumorigenesis
Prof. Dr. Hellmut G. Augustin
A05
The Wnt code: Deciphering early Wnt interactions in Hydra
Prof. Dr. Motomu Tanaka
Prof. Dr. Thomas Holstein
A07
Cell-specific activation of Wnt signaling in healing after myocardial infarction
Prof. Dr. med. Florian Leuschner
A08
Wnt pathway specificity in niche-stem cell control
Dr. Josephine Bageritz
Prof. Dr. Ingrid Lohmann
Projects B
B01
Role of DDX3X in CK1 regulation during Wnt signaling
Prof. Dr. Christof Niehrs
B02
Glycolysis-Wnt signaling axis in development and disease
Dr. Alexander Aulehla
Prof. Dr. med. Matias Simons
B03
The roles of Wnt signaling in genome stability
Prof. Dr. Sergio P. Acebrón
Prof. Dr. Holger Bastians
B05
Mathematical approaches to Wnt signaling in space and time: From development to cancer
Prof. Dr. Anna Marciniak-Czochra
B06
Wnt signaling in the adult brain: Regulation healthy and malignant stem cells
Prof. Dr. Ana Martin-Villalba
B07
Uncovering novel molecular mechanisms within Wnt signaling
Prof. Dr. Irmgard Sinning
Apl. Prof. Dr. Suat Özbek
B08
Mechanism of Wnt activation after KRAS inhibition
Prof. Dr. med. Tianzuo Zhan
B10
Decoding the role and regulation of Wnt/STOP in drug-resistant cancer cells for personalized treatment strategies
Prof. Dr. med. Laura Hinze
B11
The role of Wnt signaling in controlling neuromesodermal progenitor cell plasticity in teleost species
Jun. Prof. Dr. Lauren Saunders
Dr. Alexander Aulehla
Projects Z
Z01
Central administration
Prof. Dr. Michael Boutros
Z02
Advanced imaging
Dr. Ulrike Engel
Dr. Gary Davidson
Z03
Advanced genetic screens and genome engineering
Prof. Dr. Michael Boutros
Z04
Advanced Proteomics
Prof. Dr. Jeroen Krijgsveld
Projects (ended)
A03
Ykt6-dependent trafficking of Wnts
Prof. Dr. Julia Gross
A04
Roles of lipids in Wnt secretion and signaling
Prof. Dr. Britta Brügger
Prof. Dr. Michael Boutros
A06
Quantitative fluorescence microscopy for the analysis of Wnt pathway interactions and dynamics
Dr. Gary Davidson
Prof. Dr. Gerd Ulrich Nienhaus
B04
Wnt signaling in fate determination of retinal precursors
Prof. Dr. Joachim Wittbrodt
B09
Wnt-cilia signaling in epithelial polarization and renal development
Prof. Dr. Gislene Pereira
Prof. Dr. med. Matias Simons