The research program of our collaborative research center (CRC) 1324 consists of 15 projects and three technology platforms (projects Z) working on two research areas that are of key importance for advancing our understanding of molecular mechanisms governing Wnt signal transduction. In particular, the CRC 1324 focuses on two overarching topics:
Research focus A: Wnt secretion, trafficking and receptor-ligand interactions
• How are Wnt proteins produced, how are they modified and how are they transported in the extracellular space?
• How do Wnt ligand/receptor interactions specify the signaling response and induce different signaling cascades?
Research focus B: Wnt coupling to downstream and context-dependent signaling
• How is Wnt signaling activated and coupled to different downstream factors in a context-dependent manner?
• How are spatio-temporal dynamics of Wnt signaling controlled?