Career

"I am Johannes, a medical student at the Heidelberg University. In 2020, I joined the Boutros lab to investigate the differential regulation and function of secreted Wnt ligands in colorectal cancer (in collaboration with the Zhan lab, B08). I am very happy to work in the prolific environment of the CRC1324, which provides me with a lot of know-how on Wnt-related questions. Also, the Herbert-Steinbeisser M.D. fellowship granted by the CRC1324 strongly supports me in conducting my research."

"I am a medical student at the University of Heidelberg. I am currently working on my MD thesis in the group of Prof. Dr. Michael Boutros at the German Cancer Research Center. In January 2021, I received the „Herbert Steinbeisser M.D. Fellowship“ of the SFB 1324 „Mechanisms and Functions of Wnt Signaling“. I am especially grateful for this honor and this stipend which allows me to interact with the researchers and cooperators of the SFB. I learn a lot and I have received great suggestions and inspirations for my project entitled „Establishment of CRISPR/Cas9 RNPs as a genome editing tool for arrayed phenotypic screening in cancer cell lines and organoids“. So far, I have established CRISPR/Cas9 ribonucleoproteins (RNPs) to generate high-efficiency knockouts as a tool for arrayed high-throughput phenotypic screening in the context of Wnt signalling and colorectal cancer (CRC). I aim to identify new interactions and connections between Wnt and other signalling pathways relevant for CRC carcinogenesis and response to treatment."

"As a 6th year medical student working on my doctoral thesis, the ability to work and acquire experience in scientific research adds a great benefit to my studies. In my doctoral thesis, supported by the CRC 1324 with the Herbert Steinbeisser M.D. Fellowship, I investigate the role of non-canonical Wnt signaling after myocardial infarction in Florian Leuschner’s group. Being integrated in the CRC enables direct interaction with other fields of expertise and therefore enriches the methodical range of my project."