Prof. Dr. Sergio P. Acebrón

Project Leader B03

Department of Cell Signaling and Genome Stability
Centre for Organismal Studies (COS)
Heidelberg University

sergio.acebron@cos.uni-heidelberg.de

http://acebronlab.org/

Beruflicher Werdegang

since 2026

Ikerbasque Research Professor

Centre of Biotechnology - UPV/EHU, Spain

since 02/2023

Professor of Cell Signaling and Genome Stability

COS, Heidelberg University

since 05/2017

Independent junior group leader and lecturer

COS, Heidelberg University

2012-2017

Project leader / Senior postdoctoral fellow

German Cancer Research Center (DKFZ), Heidelberg

2009-2011

Postdoctoral fellow

German Cancer Research Center (DKFZ), Heidelberg

2008

PhD in Biochemistry

University of the Basque Country – Biophysics Unit, Bilbao, Spain. Advisor: Prof. Arturo Muga.

2004

B.Sc. / M.Sc. diploma in Biochemistry and Molecular Biology

University of the Basque Country, Bilbao, Spain

Erfolge & Auszeichnungen

2022

Hella-Bühler Preis

Heidelberg University

2019

Co-organizer

HBIGS International Winter School “Molecular mechanisms in Mitosis”, Heidelberg

since 2018

Elected representative for the junior group leaders

HMLS Research Council, Heidelberg

2017

CRUK Career Development Award

Cancer Research UK

2017

“European Witness” (Zeugen Europas)

Appointed by the DAAD to represent the integration of scientists within the European Union

2012-2015

Vice-president (2012-2014) and President (2014-2015)

Society of Spanish Researchers in Germany (CERFA)

Publikationen

The interplay between Wnt and mTOR signaling modulates ciliogenesis in human retinal epithelial cells.

Yuan C, Neuner A, Streubel J, Bhanushali A, Simons M, Acebrón SP, Pereira G. PLoS Biol. 2025 Sep 2;23(9):e3003369. doi: 10.1371/journal.pbio.3003369. eCollection 2025 Sep. PMID: 40892854

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Wnt10b signaling regulates replication stress-induced chromosomal instability in human cancer

Haas A, Wenz F, Hattemer J, Wesslowski J, Davidson G, Voloshanenko O, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2025 Aug 22;8(11):e202503295. doi: 10.26508/lsa.202503295. Print 2025 Nov. PMID: 40846632

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A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA

Smarduch S, Moreno-Velasquez SD, Ilic D, Dadsena S, Morant R, Ciprinidis A, Pereira G, Binder M, García-Sáez AJ, Acebrón SP. EMBO J. 2025 Apr;44(7):2157-2182.

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Activation of Wnt/β-catenin signaling is critical for the tumorigenesis of choroid plexus

Ho KH, Trapp M, Guida C, Ivanova EL, De Jaime-Soguero A, Jabali A, Thomas C, Salasova A, Bernatík O, Salio C, Horschitz S, Hasselblatt M, Sassoè-Pognetto M, Čajánek L, Ishikawa H, Schroten H, Schwerk C, Acebrón SP, Angel P, Koch P, Patrizi A. Neuro Oncol. 2025 Jan 12;27(1):106-122

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Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress

de Jaime-Soguero A, Hattemer J, Bufe A, Haas A, van den Berg J, van Batenburg V, Das B, di Marco B, Androulaki S, Böhly N, Landry JJM, Schoell B, Rosa VS, Villacorta L, Baskan Y, Trapp M, Benes V, Chabes A, Shahbazi M, Jauch A, Engel U, Patrizi A, Sotillo R, van Oudenaarden A, Bageritz J, Alfonso J, Bastians H, Acebrón SP. Nat Commun. 2024 Aug 28;15(1):7404. doi: 10.1038/s41467-024-51821-9. PMID: 39191776

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DEAD box RNA helicases are pervasive protein kinase interactors and activators

Hirth A, Fatti E, Netz E, Acebron SP, Papageorgiou D, Švorinić A, Cruciat CM, Karaulanov E, Gopanenko A, Zhu T, Sinning I, Krijgsveld J, Kohlbacher O, Niehrs C. Genome Res. 2024 Jul 23;34(6):952-966. doi: 10.1101/gr.278264.123. PMID: 38986579

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The origin and evolution of Wnt signalling

Holzem M, Boutros M, Holstein TW. Nat Rev Genet. 2024 Feb 19. Online ahead of print. PMID: 38374446

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DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2

Fatti E, Hirth A, Švorinić A, Günther M, Stier G, Cruciat CM, Acebrón SP, Papageorgiou D, Sinning I, Krijgsveld J, Höfer T, Niehrs C. Sci Signal. 2023 Apr 25;16(782):eabp8923. doi: 10.1126/scisignal.abp8923. Epub 2023 Apr 25. PMID: 37098120

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Wnt signalling in cell division: from mechanisms to tissue engineering

Habib SJ, Acebrón SP. Trends Cell Biol. 2022 Jun 15:S0962-8924(22)00137-4. doi: 10.1016/j.tcb.2022.05.006. Online ahead of print. PMID: 35717422

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Mitotic WNT: aligning chromosomes through KIF2A

Bufe A, Acebrón SP. Mol Cell Oncol. 2021 Dec 6;8(6):2011564. doi: 10.1080/23723556.2021.2011564. eCollection 2021. PMID: 35419471

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Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

Bufe A, García Del Arco A, Hennecke M, de Jaime-Soguero A, Ostermaier M, Lin YC, Ciprianidis A, Hattemer J, Engel U, Beli P, Bastians H, Acebrón SP. Proc Natl Acad Sci U S A. 2021 Aug 24; 118(34):e2108145118. doi:10.1073/pnas.2108145118. PMID: 34417301

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USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling

Giebel N, de Jaime-Soguero A, García Del Arco A, Landry JJM, Tietje M, Villacorta L, Benes V, Fernández-Sáiz V, Acebrón SP. EMBO Rep. 2021 Mar 30:e51415. doi: 10.15252/embr.202051415. Online ahead of print.
PMID: 33786993

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Wnt10b GSK3β dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

Lin YC, Haas A, Bufe A, Parbin S, Hennecke M, Voloshanenko O, Gross J, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2020 Nov 30;4(1):e202000855. Print 2021 Jan.
PMID: 33257473

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Parkinson associated receptor GPR37 is an ER chaperone for LRP6

Berger BS, Acebron SP, Herbst J, Koch S, Niehrs C. EMBO Rep. 2017 May;18(5):712-725. doi: 10.15252/embr.201643585. Epub 2017 Mar 24. PMID: 28341812

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Posttranscriptional Wnt signaling governs epididymal sperm maturation

Koch S, Acebron SP, Herbst J, Hatiboglu G, Niehrs C. Cell. 2015 Nov 19;163(5):1225-1236. doi: 10.1016/j.cell.2015.10.029. PMID: 26590424

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Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis

Huang YL, Anvarian Z, Döderlein G, Acebron SP, Niehrs C. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5732-7. doi: 10.1073/pnas.1423533112. Epub 2015 Apr 21. PMID: 25901317

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