Prof. Dr. Sergio P. Acebrón

Project Leader B03

Heidelberg University
Centre for Organismal Studies (COS)
Independent Research Group: Cell Signaling
Im Neuenheimer Feld 230
69120 Heidelberg

Dr. Sergio Acebrón

Professional Career

since 02/2023

Professor of Cell Signaling and Genome Stability

COS, Heidelberg University

since 05/2017

Independent junior group leader and lecturer

COS, Heidelberg University


Project leader / Senior postdoctoral fellow

German Cancer Research Center (DKFZ), Heidelberg


Postdoctoral fellow

German Cancer Research Center (DKFZ), Heidelberg


PhD in Biochemistry

University of the Basque Country – Biophysics Unit, Bilbao, Spain. Advisor: Prof. Arturo Muga.


B.Sc. / M.Sc. diploma in Biochemistry and Molecular Biology

University of the Basque Country, Bilbao, Spain

Achievements & Awards


Hella-Bühler Preis

Heidelberg University



HBIGS International Winter School “Molecular mechanisms in Mitosis”, Heidelberg

since 2018

Elected representative for the junior group leaders

HMLS Research Council, Heidelberg


CRUK Career Development Award

Cancer Research UK


“European Witness” (Zeugen Europas)

Appointed by the DAAD to represent the integration of scientists within the European Union


Vice-president (2012-2014) and President (2014-2015)

Society of Spanish Researchers in Germany (CERFA)


DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2

Fatti E, Hirth A, Švorinić A, Günther M, Stier G, Cruciat CM, Acebrón SP, Papageorgiou D, Sinning I, Krijgsveld J, Höfer T, Niehrs C. Sci Signal. 2023 Apr 25;16(782):eabp8923. doi: 10.1126/scisignal.abp8923. Epub 2023 Apr 25. PMID: 37098120

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Wnt signalling in cell division: from mechanisms to tissue engineering

Habib SJ, Acebrón SP. Trends Cell Biol. 2022 Jun 15:S0962-8924(22)00137-4. doi: 10.1016/j.tcb.2022.05.006. Online ahead of print. PMID: 35717422

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Mitotic WNT: aligning chromosomes through KIF2A

Bufe A, Acebrón SP. Mol Cell Oncol. 2021 Dec 6;8(6):2011564. doi: 10.1080/23723556.2021.2011564. eCollection 2021. PMID: 35419471

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Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

Bufe A, García Del Arco A, Hennecke M, de Jaime-Soguero A, Ostermaier M, Lin YC, Ciprianidis A, Hattemer J, Engel U, Beli P, Bastians H, Acebrón SP. Proc Natl Acad Sci U S A. 2021 Aug 24; 118(34):e2108145118. doi:10.1073/pnas.2108145118. PMID: 34417301

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USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling

Giebel N, de Jaime-Soguero A, García Del Arco A, Landry JJM, Tietje M, Villacorta L, Benes V, Fernández-Sáiz V, Acebrón SP. EMBO Rep. 2021 Mar 30:e51415. doi: 10.15252/embr.202051415. Online ahead of print.
PMID: 33786993

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Wnt10b GSK3β dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

Lin YC, Haas A, Bufe A, Parbin S, Hennecke M, Voloshanenko O, Gross J, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2020 Nov 30;4(1):e202000855. Print 2021 Jan.
PMID: 33257473

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Parkinson associated receptor GPR37 is an ER chaperone for LRP6

Berger BS, Acebron SP, Herbst J, Koch S, Niehrs C. EMBO Rep. 2017 May;18(5):712-725. doi: 10.15252/embr.201643585. Epub 2017 Mar 24. PMID: 28341812

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Posttranscriptional Wnt signaling governs epididymal sperm maturation

Koch S, Acebron SP, Herbst J, Hatiboglu G, Niehrs C. Cell. 2015 Nov 19;163(5):1225-1236. doi: 10.1016/j.cell.2015.10.029. PMID: 26590424

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Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis

Huang YL, Anvarian Z, Döderlein G, Acebron SP, Niehrs C. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5732-7. doi: 10.1073/pnas.1423533112. Epub 2015 Apr 21. PMID: 25901317

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