Prof. Dr. Michael Boutros
Project Leader A01, A04, Z01, Z03
Heidelberg University, Medical Faculty Heidelberg & DKFZ
BioQuant - Center for Quantitative Analysis of Molecular and Cellular Biosystems
Im Neuenheimer Feld 267
D-69120 Heidelberg
boutros@mk.uni-heidelberg.de
Beruflicher Werdegang
since October 2023
Dean
Medical Faculty Heidelberg, Heidelberg University Hospital
since 2020
Director
Marsilius Kolleg, Heidelberg University
since 2008
Professor for Cell- and Molecular Biology
Medical Faculty Mannheim, Heidelberg University, Heidelberg
since 2008
Head of Division
Signaling and Functional Genomics, German Cancer Research Center, Heidelberg
2003-2007
Group leader
Emmy Noether Program of the DFG, German Cancer Research Center, Heidelberg
1999-2003
Postdoctoral research fellow
Norbert Perrimon, Department of Genetics, Harvard Medical School, Boston, USA
2001
M.P.A.
Kennedy School of Government, Harvard University, Boston, USA
1999
Dr. rer. nat.
European Molecular Biology Laboratory and Heidelberg University; Advisor: Prof. Marek Mlodzik
Erfolge & Auszeichnungen
since 2021
Speaker
DFG Collaborative Research Center 1324
since 2020
Speaker
Research and Strategy Commission, Heidelberg University
since 2019
Coordinating PI
ERC Synergy Grant DECODE
2017-2021
Vice-Speaker
DFG Collaborative Research Center 1324
since 2016
Elected Member
DFG panel 201-02 ‘Genetics’
2015-2016
Scientific Director (interim)
German Cancer Research Center, Heidelberg
since 2014
Editorial Board Member
Molecular Systems Biology
2010-2014
Elected member
Senate of Heidelberg University
2013
EMBO Member
European Molecular Biology Organization
2012
ERC Advanced Grant
European Research Council
since 2012
Member of the Executive Board and PI
Excellence Cluster CellNetworks, Heidelberg
since 2012
University Member of the Board (Kuratorium) and since 2014 Deputy Chair of Board
Studienstiftung des deutschen Volkes
2011-2013
Vice Dean for Research
Medical Faculty Mannheim, Heidelberg University
since 2008
Member of the Executive Board and PI
HBIGS (Excellence Initiative), Heidelberg University
2007
Johann-Georg Zimmermann Award for Cancer Research
Funded by the German Hypothekenbank AG in cooperation with the Hannover Medical School
2005
EMBO Young Investigator Award
European Molecular Biology Organization
2003
Member
Die Junge Akademie at the Berlin-Brandenburgischen Academy of Science and the Academy Leopoldina
2001-2003
Emmy-Noether Postdoctoral Fellowship and Junior Group
DFG
1997-1999
Ph.D. fellowship
Boehringer Ingelheim
1991-1999
Fellow
Studienstiftung des deutschen Volkes
Publikationen
The origin and evolution of Wnt signalling
Nat Rev Genet. 2024 Feb 19. Online ahead of print. PMID: 38374446
Mehr erfahrenA temperature-tolerant CRISPR base editor mediates highly efficient and precise gene editing in Drosophila
Sci Adv. 2023 Sep;9(35):eadj1568. doi: 10.1126/sciadv.adj1568. Epub 2023 Aug 30. PMID: 37647411
Mehr erfahrenGlyoxal as alternative fixative for single cell RNA sequencing
The Roles of Secreted Wnt Ligands in Cancer
Int J Mol Sci. 2023 Mar 10;24(6):5349. doi: 10.3390/ijms24065349. PMID: 36982422
Mehr erfahrenThe role of Evi/Wntless in exporting Wnt proteins
Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response
Tissue-Specific CRISPR-Cas9 Screening in Drosophila
Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates
Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122476119. doi: 10.1073/pnas.2122476119. Epub 2022 Jul 22. PMID: 35867833
Mehr erfahrenAllele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
EVI/WLS function is regulated by ubiquitination and linked to ER-associated degradation by ERLIN2
A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver
Dev Cell. 2021 Jun 7;56(11):1677-1693.e10. PMID: 34038707
Mehr erfahrenMulti-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155
Wnt10b GSK3β dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells
Extracellular vesicles and oncogenic signaling
Mol Oncol. 2020 Nov 18. doi: 10.1002/1878-0261.12855. PMID: 33207034
Mehr erfahrenMultiplexed conditional genome editing with Cas12a in Drosophila
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled
Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G. J Biol Chem. 2020 May 7. pii: jbc.RA120.012892. PMID:32381507
Mehr erfahrengscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection
Imkeller K, Ambrosi G, Boutros M, Huber W. Genome Biol. 2020 Mar 2; 21(1):53. PMID: 32122365
Mehr erfahrenA Large-Scale Resource for Tissue-Specific CRISPR Mutagenesis in Drosophila
Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium
Chaudhary V, Boutros M. PLoS Genet. 2019 Sep 17;15(9):e1008351. PMID: 31527874
Mehr erfahrenRobust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing
Chaudhary V, Hingole S, Frei J, Port F, Strutt D, Boutros M. Development. 2019 Aug 9;146(15). PMID: 31399474
Mehr erfahrenGene expression atlas of a developing tissue by single cell expression correlation analysis
Nat Methods. 2019 Aug;16(8):750-756. doi: 10.1038/s41592-019-0492-x. Epub 2019 Jul 29. PMID: 31363221
Mehr erfahrenMEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
Nat Commun. 2019 May 16;10(1):2197. doi: 10.1038/s41467-019-09898-0. PMID: 31097693
Mehr erfahrenWEADE: a workflow for enrichment analysis and data exploration
PLoS One. 2018 Sep 28;13(9):e0204016. doi: 10.1371/journal.pone.0204016. eCollection 2018. PMID: 30265728
Mehr erfahrenDecoding the regulatory logic of the Drosophila male stem cell system
Cell Rep. 2018 Sep 11;24(11):3072-3086. doi: 10.1016/j.celrep.2018.08.013. PMID: 30208329
Mehr erfahrenToward an integrated map of genetic interactions in cancer cells
Mol Syst Biol. 2018 Feb 21;14(2):e7656. doi: 10.15252/msb.20177656. PMID: 29467179
Mehr erfahrenβ-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells
Voloshanenko O, Schwartz U, Kranz D, Rauscher B, Linnebacher M, Augustin I, Boutros M. Sci Rep. 2018 Feb 16;8(1):3178. PMID:29453334
Mehr erfahrenERAD-dependent control of the Wnt secretory factor Evi
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. EMBO J. 2018 Feb 15;37(4). PMID:29378775
Mehr erfahrenThe cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction
EMBO Mol Med. 2017 Sep;9(9):1279-1293. doi: 10.15252/emmm.201707565. PMID: 28774883
Mehr erfahrenMapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families
FASEB J. 2017 Nov;31(11):4832-4844. doi: 10.1096/fj.201700144R. Epub 2017 Jul 21. PMID: 28733458
Mehr erfahrenMolecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity
BMC Biol. 2014 May 30;12:44. doi: 10.1186/1741-7007-12-44. PMID: 24885675
Mehr erfahrenThe microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis
J Cell Biol. 2013 Feb 18;200(4):505-22. doi: 10.1083/jcb.201206013. Epub 2013 Feb 11. PMID: 23400999
Mehr erfahrenActive Wnt proteins are secreted on exosomes
Cell cycle control of wnt receptor activation
Dev Cell. 2009 Dec;17(6):788-99. doi: 10.1016/j.devcel.2009.11.006. PMID: 20059949
Mehr erfahrenSecretion of Wnt ligands requires Evi, a conserved transmembrane protein
Cell. 2006 May 5;125(3):523-33. doi: 10.1016/j.cell.2006.04.009. PMID: 16678096
Mehr erfahren