Prof. Dr. Michael Boutros

Project Leader A01, A04, Z01, Z03

Heidelberg University
Department of Cell and Molecular biology / MEDMA & DKFZ
BioQuant - Center for Quantitative Analysis of Molecular and Cellular Biosystems
Im Neuenheimer Feld 267
D-69120 Heidelberg

Prof. Dr. Michael Boutros

Professional Career

since 2020

Director

Marsilius Kolleg, Heidelberg University

since 2008

Professor for Cell- and Molecular Biology

Medical Faculty Mannheim, Heidelberg University, Heidelberg

since 2008

Head of Division

Signaling and Functional Genomics, German Cancer Research Center, Heidelberg

2003-2007

Group leader

Emmy Noether Program of the DFG, German Cancer Research Center, Heidelberg

1999-2003

Postdoctoral research fellow

Norbert Perrimon, Department of Genetics, Harvard Medical School, Boston, USA

2001

M.P.A.

Kennedy School of Government, Harvard University, Boston, USA

1999

Dr. rer. nat.

European Molecular Biology Laboratory and Heidelberg University; Advisor: Prof. Marek Mlodzik

Achievements & Awards

since 2021

Speaker

DFG Collaborative Research Center 1324

since 2020

Speaker

Research and Strategy Commission, Heidelberg University

since 2019

Coordinating PI

ERC Synergy Grant DECODE

2017-2021

Vice-Speaker

DFG Collaborative Research Center 1324

since 2016

Elected Member

DFG panel 201-02 ‘Genetics’

2015-2016

Scientific Director (interim)

German Cancer Research Center, Heidelberg

since 2014

Editorial Board Member

Molecular Systems Biology

2010-2014

Elected member

Senate of Heidelberg University

2013

EMBO Member

European Molecular Biology Organization

2012

ERC Advanced Grant

European Research Council

since 2012

Member of the Executive Board and PI

Excellence Cluster CellNetworks, Heidelberg

since 2012

University Member of the Board (Kuratorium) and since 2014 Deputy Chair of Board

Studienstiftung des deutschen Volkes

2011-2013

Vice Dean for Research

Medical Faculty Mannheim, Heidelberg University

since 2008

Member of the Executive Board and PI

HBIGS (Excellence Initiative), Heidelberg University

2007

Johann-Georg Zimmermann Award for Cancer Research

Funded by the German Hypothekenbank AG in cooperation with the Hannover Medical School

2005

EMBO Young Investigator Award

European Molecular Biology Organization

2003

Member

Die Junge Akademie at the Berlin-Brandenburgischen Academy of Science and the Academy Leopoldina

2001-2003

Emmy-Noether Postdoctoral Fellowship and Junior Group

DFG

1997-1999

Ph.D. fellowship

Boehringer Ingelheim

1991-1999

Fellow

Studienstiftung des deutschen Volkes

Publications

Tissue-Specific CRISPR-Cas9 Screening in Drosophila

Port F, Boutros M. Methods Mol Biol. 2022;2540:157-176. doi: 10.1007/978-1-0716-2541-5_7. PMID: 35980577

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Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates

Schubert A, Voloshanenko O, Ragaller F, Gmach P, Kranz D, Scheeder C, Miersch T, Schulz M, Trümper L, Binder C, Lampe M, Engel U, Boutros M. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122476119. doi: 10.1073/pnas.2122476119. Epub 2022 Jul 22. PMID: 35867833

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Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11:e64498. doi: 10.7554/eLife.64498.
PMID: 35014953

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EVI/WLS function is regulated by ubiquitination and linked to ER-associated degradation by ERLIN2

Wolf LM, Lambert AM, Haenlin J, Boutros M. J Cell Sci. 2021 Jul 19:jcs.257790. doi: 10.1242/jcs.257790. Online ahead of print.
PMID: 3427964

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A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Vélez PA, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG. Dev Cell. 2021 Jun 7;56(11):1677-1693.e10. PMID: 34038707

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Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155

Zhan T, Faehling V, Rauscher B, Betge J, Ebert MP, Boutros M. Int J Cancer. 2021 Apr 15;148(8):1948-1963. doi: 10.1002/ijc.33393. Epub 2020 Dec 4.
PMID: 33186476

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Wnt10b GSK3β dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

Lin YC, Haas A, Bufe A, Parbin S, Hennecke M, Voloshanenko O, Gross J, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2020 Nov 30;4(1):e202000855. Print 2021 Jan.
PMID: 33257473

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Extracellular vesicles and oncogenic signaling

Schubert A, Boutros M. Mol Oncol. 2020 Nov 18. doi: 10.1002/1878-0261.12855. PMID: 33207034

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Multiplexed conditional genome editing with Cas12a in Drosophila

Port F, Starostecka M, Boutros M. Proc Natl Acad Sci U S A. 2020 Aug 25:202004655.

PMID: 32843348

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eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G. J Biol Chem. 2020 May 7. pii: jbc.RA120.012892. PMID:32381507

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gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection

Imkeller K, Ambrosi G, Boutros M, Huber W. Genome Biol. 2020 Mar 2; 21(1):53. PMID: 32122365

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A Large-Scale Resource for Tissue-Specific CRISPR Mutagenesis in Drosophila

Port F, Strein C, Stricker M, Rauscher B, Heigwer F, Zhou J, Beyersdörffer C, Frei J, Hess A, Kern K, Lange L, Langner N, Malamud R, Pavlović B, Rädecke K, Schmitt L, Voos L, Valentini E, Boutros M. Elife. 2020 Feb 13;9:e53865.

PMID: 32053108

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Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium

Chaudhary V, Boutros M. PLoS Genet. 2019 Sep 17;15(9):e1008351. PMID: 31527874

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Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing

Chaudhary V, Hingole S, Frei J, Port F, Strutt D, Boutros M. Development. 2019 Aug 9;146(15). PMID: 31399474

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Gene expression atlas of a developing tissue by single cell expression correlation analysis

Bageritz J, Willnow P, Valentini E, Leible S, Boutros M, Teleman AA. Nat Methods. 2019 Aug;16(8):750-756. doi: 10.1038/s41592-019-0492-x. Epub 2019 Jul 29. PMID: 31363221

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MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Zhan T, Ambrosi G, Wandmacher AM, Rauscher B, Betge J, Rindtorff N, Häussler RS, Hinsenkamp I, Bamberg L, Hessling B, Müller-Decker K, Erdmann G, Burgermeister E, Ebert MP, Boutros M. Nat Commun. 2019 May 16;10(1):2197. doi: 10.1038/s41467-019-09898-0. PMID: 31097693

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WEADE: a workflow for enrichment analysis and data exploration

Trost N, Rempel E, Ermakova O, Tamirisa S, Pârcălăbescu L, Boutros M, Lohmann JU, Lohmann I. PLoS One. 2018 Sep 28;13(9):e0204016. doi: 10.1371/journal.pone.0204016. eCollection 2018. PMID: 30265728

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Decoding the regulatory logic of the Drosophila male stem cell system

Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I. Cell Rep. 2018 Sep 11;24(11):3072-3086. doi: 10.1016/j.celrep.2018.08.013. PMID: 30208329

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Toward an integrated map of genetic interactions in cancer cells

Rauscher B, Heigwer F, Henkel L, Hielscher T, Voloshanenko O, Boutros M. Mol Syst Biol. 2018 Feb 21;14(2):e7656. doi: 10.15252/msb.20177656. PMID: 29467179

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β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells

Voloshanenko O, Schwartz U, Kranz D, Rauscher B, Linnebacher M, Augustin I, Boutros M. Sci Rep. 2018 Feb 16;8(1):3178. PMID:29453334

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ERAD-dependent control of the Wnt secretory factor Evi

Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. EMBO J. 2018 Feb 15;37(4). PMID:29378775  

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The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction

Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, Katus HA, Hardt SE, Leuschner F. EMBO Mol Med. 2017 Sep;9(9):1279-1293. doi: 10.15252/emmm.201707565. PMID: 28774883

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Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families

Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M. FASEB J. 2017 Nov;31(11):4832-4844. doi: 10.1096/fj.201700144R. Epub 2017 Jul 21. PMID: 28733458

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Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

Kumar S, Žigman M, Patel TR, Trageser B, Gross JC, Rahm K, Boutros M, Gradl D, Steinbeisser H, Holstein T, Stetefeld J, Özbek S. BMC Biol. 2014 May 30;12:44. doi: 10.1186/1741-7007-12-44. PMID: 24885675

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The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis

Kuhns S, Schmidt KN, Reymann J, Gilbert DF, Neuner A, Hub B, Carvalho R, Wiedemann P, Zentgraf H, Erfle H, Klingmüller U, Boutros M, Pereira G. J Cell Biol. 2013 Feb 18;200(4):505-22. doi: 10.1083/jcb.201206013. Epub 2013 Feb 11. PMID: 23400999

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Active Wnt proteins are secreted on exosomes

Gross JC, Chaudhary V, Bartscherer K, Boutros M. Nat Cell Biol. 2012 Oct;14(10):1036-45. doi: 10.1038/ncb2574. Epub 2012 Sep 16. PMID: 22983114

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Cell cycle control of wnt receptor activation

Davidson G, Shen J, Huang YL, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M, Niehrs C. Dev Cell. 2009 Dec;17(6):788-99. doi: 10.1016/j.devcel.2009.11.006. PMID: 20059949

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Secretion of Wnt ligands requires Evi, a conserved transmembrane protein

Bartscherer K, Pelte N, Ingelfinger D, Boutros M. Cell. 2006 May 5;125(3):523-33. doi: 10.1016/j.cell.2006.04.009. PMID: 16678096

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