Prof. Dr. med. Matias Simons
Project Leader B02
Institute of Human Genetics
University Hospital Heidelberg
Medical Faculty Heidelberg
Heidelberg University
matias.simons@med.uni-heidelberg.de
Beruflicher Werdegang
since 2021
Deputy Director
Insitute of Human Genetics, University Hospital Heidelberg, Heidelberg University
since 2020
Heisenberg W3-Professor for Molecular Human Genetics
University Hospital Heidelberg, Heidelberg University
since 2020
Head of Section for Nephrogenetics at the Institute of Human Genetics
University Hospital Heidelberg, Heidelberg University
since 2018
Research Director
INSERM (permanent position), Paris, France
2016
Habilitation à diriger des recherches (HDR)
Université Paris-Descartes, France
2014 - 2019
Liliane Bettencourt Chair of Developmental Biology
Group leader at Imagine Institute Hôpital Necker, Paris Descartes University, Paris, France
2009 - 2014
W2/W3-Professorship for Medical Systems Biology
Faculty of Medicine, University of Freiburg
2008 - 2014
Emmy-Noether fellow
Group Leader at the Renal Division, University Hospital Freiburg
2005 - 2008
Postdoctoral Fellow
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, USA
2002 - 2005
Clinical Resident and Postdoctoral Fellow
Department of Medicine, Renal Division, University Hospital Freiburg
2002
Dr. med.
Heidelberg University (MD Thesis at the Institute of Anatomy and Cell Biology, Heidelberg University; EMBL, Heidelberg and Albert Einstein College of Medicine, Bronx, NY, USA)
Erfolge & Auszeichnungen
2024
ERC proof-of-concept grant
European Research Council
2020
Carl-Ludwig Award
German Society for Nephrology
2019
ERC Consolidator Grant
European Research Council
2019
Heisenberg fellow
German Research Foundation (DFG)
2015
ATIP Avenir-recipient
Inserm and the French National Center for Scientific Research (CNRS)
2015
ANR @traction recipient
Inserm and the French National Center for Scientific Research (CNRS)
2011 - 2014
Associated Member
DFG Graduate Program (GRK1104: From cells to organs: Molecular Mechanisms of Organogenesis), University of Freiburg
2011 - 2014
Board of Directors
Center of the Systems Biology (ZBSA), University of Freiburg
2011 - 2014
Associated Member
DFG Excellence Cluster BIOSS (Centre for Biological Signaling Studies)
2010 - 2014
Member
Freiburg Center for Rare Diseases
2010 - 2014
Scientific member
ZBSA, University of Freiburg
2009 - 2012
Associated Member
DFG Collaborative Research Center (SFB 592: Signaling Mechanisms in Embryogenesis and Organogenesis), University of Freiburg
2009 - 2014
Emmy-Noether fellow
DFG
2007 - 2008
Fellow
DFG (Auslandsstipendium)
2005 - 2007
EMBO long term fellow
European Molecular Biology Organization
2005
Theodor-Frerichs-Award
German Society for Internal Medicine
2000
EMBO short term fellow
European Molecular Biology Organization
Publikationen
The interplay between Wnt and mTOR signaling modulates ciliogenesis in human retinal epithelial cells.
Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A
Cell Rep. 2019 Dec 24;29(13):4407-4421.e5. doi: 10.1016/j.celrep.2019.11.066. PMID: 31875549
Mehr erfahrenDrosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking
EMBO J. 2013 Jan 23;32(2):245-59. doi: 10.1038/emboj.2012.323. Epub 2013 Jan 4. PMID: 23292348
Mehr erfahrenRegulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit
Curr Biol. 2010 Jul 27;20(14):1269-76. doi: 10.1016/j.cub.2010.05.057. Epub 2010 Jun 24. PMID: 20579879
Mehr erfahrenElectrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization
Nat Cell Biol. 2009 Mar;11(3):286-94. doi: 10.1038/ncb1836. Epub 2009 Feb 22. PMID: 19234454
Mehr erfahrenInversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways
Nat Genet. 2005 May;37(5):537-43. doi: 10.1038/ng1552. Epub 2005 Apr 24. PMID: 15852005
Mehr erfahren