Prof. Dr. med. Matias Simons

Project Leader B09

Heidelberg University
University Hospital Heidelberg
Institute of Human Genetics
Im Neuenheimer Feld 366
D-69120 Heidelberg

Prof. Dr. med. Matias Simons

Professional Career

since 2020

Heisenberg W3-Professor for Molecular Human Genetics

University Hospital Heidelberg, Heidelberg University

since 2020

Head of Section for Nephrogenetics at the Institute of Human Genetics

University Hospital Heidelberg, Heidelberg University

since 2018

Research Director

INSERM (permanent position), Paris, France

2016

Habilitation à diriger des recherches (HDR)

Université Paris-Descartes, France

2014 - 2019

Liliane Bettencourt Chair of Developmental Biology

Group leader at Imagine Institute Hôpital Necker, Paris Descartes University, Paris, France

2009 - 2014

W2/W3-Professorship for Medical Systems Biology

Faculty of Medicine, University of Freiburg

2008 - 2014

Emmy-Noether fellow

Group Leader at the Renal Division, University Hospital Freiburg

2005 - 2008

Postdoctoral Fellow

Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, USA

2002 - 2005

Clinical Resident and Postdoctoral Fellow

Department of Medicine, Renal Division, University Hospital Freiburg

2002

Dr. med.

Heidelberg University (MD Thesis at the Institute of Anatomy and Cell Biology, Heidelberg University; EMBL, Heidelberg and Albert Einstein College of Medicine, Bronx, NY, USA)

Achievements & Awards

2020

Carl-Ludwig Award

German Society for Nephrology

2019

ERC Consolidator Grant

European Research Council

2019

Heisenberg fellow

German Research Foundation (DFG)

2015

ATIP Avenir-recipient

Inserm and the French National Center for Scientific Research (CNRS)

2015

ANR @traction recipient

Inserm and the French National Center for Scientific Research (CNRS)

2011 - 2014

Associated Member

DFG Graduate Program (GRK1104: From cells to organs: Molecular Mechanisms of Organogenesis), University of Freiburg

2011 - 2014

Board of Directors

Center of the Systems Biology (ZBSA), University of Freiburg

2011 - 2014

Associated Member

DFG Excellence Cluster BIOSS (Centre for Biological Signaling Studies)

2010 - 2014

Member

Freiburg Center for Rare Diseases

2010 - 2014

Scientific member

ZBSA, University of Freiburg

2009 - 2012

Associated Member

DFG Collaborative Research Center (SFB 592: Signaling Mechanisms in Embryogenesis and Organogenesis), University of Freiburg

2009 - 2014

Emmy-Noether fellow

DFG

2007 - 2008

Fellow

DFG (Auslandsstipendium)

2005 - 2007

EMBO long term fellow

European Molecular Biology Organization

2005

Theodor-Frerichs-Award

German Society for Internal Medicine

2000

EMBO short term fellow

European Molecular Biology Organization

Publications

Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A

Marchesin V, Pérez-Martí A, Le Meur G, Pichler R, Grand K, Klootwijk ED, Kesselheim A, Kleta R, Lienkamp S, Simons M. Cell Rep. 2019 Dec 24;29(13):4407-4421.e5. doi: 10.1016/j.celrep.2019.11.066. PMID: 31875549

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Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking

Hermle T, Guida MC, Beck S, Helmstädter S, Simons M. EMBO J. 2013 Jan 23;32(2):245-59. doi: 10.1038/emboj.2012.323. Epub 2013 Jan 4. PMID: 23292348

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Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit

Hermle T, Saltukoglu D, Grünewald J, Walz G, Simons M. Curr Biol. 2010 Jul 27;20(14):1269-76. doi: 10.1016/j.cub.2010.05.057. Epub 2010 Jun 24. PMID: 20579879

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Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization

Simons M, Gault WJ, Gotthardt D, Rohatgi R, Klein TJ, Shao Y, Lee HJ, Wu AL, Fang Y, Satlin LM, Dow JT, Chen J, Zheng J, Boutros M, Mlodzik M. Nat Cell Biol. 2009 Mar;11(3):286-94. doi: 10.1038/ncb1836. Epub 2009 Feb 22. PMID: 19234454

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Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Krönig C, Schermer B, Benzing T, Cabello OA, Jenny A, Mlodzik M, Polok B, Driever W, Obara T, Walz G. Nat Genet. 2005 May;37(5):537-43. doi: 10.1038/ng1552. Epub 2005 Apr 24. PMID: 15852005

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