Prof. Dr. med. Tianzuo Zhan

Project Leader B08

Translational Gastrointestinal Oncology – Therapy resistance of colorectal cancer
Department of Medicine II
Mannheim University Hospital
Medical Faculty Mannheim
Heidelberg University

tianzuo.zhan@umm.de

https://www.umm.de/ii-medizinische-klinik/forschung-lehre/arbeitsgruppen/ag-zhan/

Beruflicher Werdegang

2025

adjunct Professor, Heidelberg University

Since 2023

Senior physician, Department of Medicine II, Medical Faculty Mannheim

2021

Habilitation in Experimental Medicine

since 2019

Fellow

DFG-Clinician Scientist Program “Interfaces and Interventions in Complex Chronic Conditions”, Heidelberg University, Medical Faculty Mannheim

since 2019

Junior Research Group Leader “Translational GI Oncology”

Department of Medicine II, Mannheim University Hospital, Mannheim

2013 - 2018

Postdoctoral research fellow,

Division Signaling and Functional Genomics, German Cancer Research Center, Heidelberg

since 2012

Training in Internal Medicine

Department of Medicine II, Mannheim University Hospital, Mannheim

2011

MD degree

Heidelberg University

Erfolge & Auszeichnungen

2021

Research Excellence Award

Medical Faculty Mannheim, Heidelberg University

2020

Travel grant

German Cancer Aid, and best abstract selection, German Cancer Congress

2019

Cancer Research award

Oncology Working Group Mannheim

2018

Adolf Kußmaul award

Southwest German Society of Gastroenterology

2016

Otto Porges abstract award

German Society for Digestive and Metabolic Diseases

2013

Fellowship grant

DKFZ International Postdoc Program

2011

Travel grant

best doctoral thesis, German Society for Digestive and Metabolic Diseases

2004-2011

Scholarship

German National Academic Foundation

Publikationen

Combined MEK and PARP inhibition enhances radiation response in rectal cancer

Xiao Q, Riedesser JE, Mulholland T, Li Z, Buchloh J, Albrecht P, Yang X, Li M, Venkatachalam N, Skabkina O, Klupsch A, Eichhorn E, Wang L, Belle S, Schulte N, Schmitz D, Froelich MF, Trikhirhisthit K, Valentini E, Boonekamp KE, Petersen Y, Miersch T, Burgermeister E, Herskind C, Veldwijk MR, Brochhausen C, Ihnatko R, Krijgsveld J, Kurth I, Zhu Y, Ma Y, Cao K, Boutros M, Ebert MP, Zhan T, Betge J. Cell Rep Med. 2025 Aug 5:102284. doi: 10.1016/j.xcrm.2025.102284. Online ahead of print.

Mehr erfahren

Digestive cancers: mechanisms, therapeutics and management

Mehr erfahren

The Roles of Secreted Wnt Ligands in Cancer

Werner J, Boonekamp KE, Zhan T, Boutros M. Int J Mol Sci. 2023 Mar 10;24(6):5349. doi: 10.3390/ijms24065349. PMID: 36982422

Mehr erfahren

Cross-Talk between p53 and Wnt Signaling in Cancer

Xiao Q, Werner J, Venkatachalam N, Boonekamp KE, Ebert MP, Zhan T. Biomolecules. 2022 Mar 15;12(3):453. doi: 10.3390/biom12030453. PMID: 35327645

Mehr erfahren

Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155

Zhan T, Faehling V, Rauscher B, Betge J, Ebert MP, Boutros M. Int J Cancer. 2021 Apr 15;148(8):1948-1963. doi: 10.1002/ijc.33393. Epub 2020 Dec 4.

PMID: 33186476

Mehr erfahren

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Zhan T, Ambrosi G, Wandmacher AM, Rauscher B, Betge J, Rindtorff N, Häussler RS, Hinsenkamp I, Bamberg L, Hessling B, Müller-Decker K, Erdmann G, Burgermeister E, Ebert MP, Boutros M. Nat Commun. 2019 May 16;10(1):2197. doi: 10.1038/s41467-019-09898-0. PMID: 31097693

Mehr erfahren

CRISPR/Cas9 for cancer research and therapy

Zhan T, Rindtorff N, Betge J, Ebert MP, Boutros M. Semin Cancer Biol. 2019 Apr;55:106-119. doi: 10.1016/j.semcancer.2018.04.001. Epub 2018 Apr 16. PMID: 29673923

Mehr erfahren

Wnt signaling in cancer

Zhan T, Rindtorff N, Boutros M. Oncogene. 2017 Mar;36(11):1461-1473. doi: 10.1038/onc.2016.304. Epub 2016 Sep 12. PMID: 27617575

Mehr erfahren

CRISPRlibrary designer (CLD): software for multispecies design of single guide RNA libraries.

Heigwer F, Zhan T, Breinig M, Winter J, Brügemann D, Leible S, Boutros M. Genome Biol. 2016 Mar 24;17:55. doi: 10.1186/s13059-016-0915-2. PMID: 27013184

Mehr erfahren