Dr. med. Tianzuo Zhan

Project Leader B08

Heidelberg University
Medical Faculty Mannheim
Mannheim University Hospital
Department of Medicine II
Theodor-Kutzer-Ufer 1-3
D-68167 Mannheim

Professional Career

since 2019


DFG-Clinician Scientist Program “Interfaces and Interventions in Complex Chronic Conditions”, Heidelberg University, Medical Faculty Mannheim

since 2019

Junior Research Group Leader “Translational GI Oncology”

Department of Medicine II, Mannheim University Hospital, Mannheim

2013 - 2018

Postdoctoral research fellow,

Division Signaling and Functional Genomics, German Cancer Research Center, Heidelberg

since 2012

Training in Internal Medicine

Department of Medicine II, Mannheim University Hospital, Mannheim


MD degree

Heidelberg University

Achievements & Awards


Travel grant

German Cancer Aid, and best abstract selection, German Cancer Congress


Cancer Research award

Oncology Working Group Mannheim


Adolf Kußmaul award

Southwest German Society of Gastroenterology


Otto Porges abstract award

German Society for Digestive and Metabolic Diseases


Fellowship grant

DKFZ International Postdoc Program


Travel grant

best doctoral thesis, German Society for Digestive and Metabolic Diseases



German National Academic Foundation


The Roles of Secreted Wnt Ligands in Cancer

Werner J, Boonekamp KE, Zhan T, Boutros M. Int J Mol Sci. 2023 Mar 10;24(6):5349. doi: 10.3390/ijms24065349. PMID: 36982422

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Cross-Talk between p53 and Wnt Signaling in Cancer

Xiao Q, Werner J, Venkatachalam N, Boonekamp KE, Ebert MP, Zhan T. Biomolecules. 2022 Mar 15;12(3):453. doi: 10.3390/biom12030453. PMID: 35327645

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Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155

Zhan T, Faehling V, Rauscher B, Betge J, Ebert MP, Boutros M. Int J Cancer. 2021 Apr 15;148(8):1948-1963. doi: 10.1002/ijc.33393. Epub 2020 Dec 4.
PMID: 33186476

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MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Zhan T, Ambrosi G, Wandmacher AM, Rauscher B, Betge J, Rindtorff N, Häussler RS, Hinsenkamp I, Bamberg L, Hessling B, Müller-Decker K, Erdmann G, Burgermeister E, Ebert MP, Boutros M. Nat Commun. 2019 May 16;10(1):2197. doi: 10.1038/s41467-019-09898-0. PMID: 31097693

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CRISPR/Cas9 for cancer research and therapy

Zhan T, Rindtorff N, Betge J, Ebert MP, Boutros M. Semin Cancer Biol. 2019 Apr;55:106-119. doi: 10.1016/j.semcancer.2018.04.001. Epub 2018 Apr 16. PMID: 29673923

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Wnt signaling in cancer

Zhan T, Rindtorff N, Boutros M. Oncogene. 2017 Mar;36(11):1461-1473. doi: 10.1038/onc.2016.304. Epub 2016 Sep 12. PMID: 27617575

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CRISPRlibrary designer (CLD): software for multispecies design of single guide RNA libraries.

Heigwer F, Zhan T, Breinig M, Winter J, Brügemann D, Leible S, Boutros M. Genome Biol. 2016 Mar 24;17:55. doi: 10.1186/s13059-016-0915-2. PMID: 27013184

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