Prof. Dr. Hellmut G. Augustin

Project Leader A02

European Center for Angioscience (ECAS)
Medical Faculty Mannheim, Heidelberg University & German Cancer Research Center (DKFZ)

augustin@angioscience.de

http://www.angiolab.de/

Professional Career

since 2018

Founding Director

European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University

since 2016

Chair for Vascular Biology and Angiogenesis Research

Medical Faculty Mannheim (CBTM), Heidelberg University & German Cancer Research Center Heidelberg

2011-2017

Deputy Director

Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University

2011-2016

Director

Center for Molecular Biology & German Cancer Research Center Alliance, Heidelberg

2011-2016

Speaker

Cell & Tumor Biology Research Program, German Cancer Research Center, Heidelberg

2006-2016

Aventis Foundation-endowed Chair for Vascular Biology and Angiogenesis Research

Medical Faculty Mannheim (CBTM), Heidelberg University, and German Cancer Research Center Heidelberg

2002-2006

Adjunct Professor

Medical Faculty of the Albert-Ludwigs-University Freiburg

2001-2006

Head

Dept. of Vascular Biology & Angiogenesis Research, Tumor Biology Center, Freiburg

1992-2001

Research Assistant Professor (C1, C2)

University of Göttingen

1997

Venia legendi (Habilitation) in Molecular Cell Biology

University of Göttingen

1997

Ph.D.

Cornell University, Ithaca, NY, USA Advisor: Professor Bendicht Pauli

1992

Dr. med. vet.

School of Veterinary Medicine Hannover Advisor: Professor Siegfried Ueberschär

Achievements & Awards

2026

Proof of Concept Grant

ERC grant

2022

Grant

‘High Risk – High Gain’, Deutsche Krebshilfe

since 2019

Spokesperson

DFG Collaborative Research Center (CRC1366) ‘Vascular Control of Organ Function’ of Heidelberg University

since 2016

Co-Chair

Committee for Structure and Development of the Medical Faculty Mannheim of Heidelberg University

since 2015

Member of the Steering Committee

DFG Research Training Group (RTG2099) ‘Hallmarks of Skin Cancer’ of Heidelberg University

2014

Heidelberg Molecular Life Sciences (HMLS) Investigator Award

Heidelberg University

2013-2016

Director

Helmholtz Alliance ’Preclinical Comprehensive Cancer Center’

2009-2017

Spokesperson

DFG Collaborative Research Center (CRC-TR23) ’Vascular Differentiation and Remodeling’ of the Universities Heidelberg and Frankfurt

since 2005

Founding member and elected Chairman

VWFB e.V. (Verein zur Förderung wissenschaftlicher Fachtagungen e.v.).

2005 - 2012

Coordinator

nationwide German Priority Research Grant SPP 1190 ’The Tumor- Vessel Interface’

2003

Binder Innovation Award

German Society of Cell Biology

1998-2006

Coordinator

nationwide German Priority Research Grant ‘Angiogenesis’ (SPP1069)

1997

Erich-Aehnelt Award for best doctoral thesis

School of Veterinary Medicine, Hannover

Publications

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee KH, Geng Y, Rajbhandari P, Hernandez C, Steffani M, Qie J, Savage T, Goyal DM, Ray KC, Neelakantan TV, Yin D, Melms J, Lehrich BM, Yasaka TM, Liu S, Oertel M, Lan T, Guillot A, Peiseler M, Filliol A, Kanzaki H, Fujiwara N, Ravi S, Izar B, Brosch M, Hampe J, Remotti H, Argemi J, Sun Z, Kendall TJ, Hoshida Y, Tacke F, Fallowfield JA, Blockley-Powell SK, Haeusler RA, Steinman JB, Pajvani UB, Monga SP, Bataller R, Masoodi M, Arpaia N, Lee YA, Stockwell BR, Augustin HG, Schwabe RF. Nature. 2025 Mar 12.

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The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms

Gehrs S, Jakab M, Gutjahr E, Gu Z, Weichenhan D, Mallm JP, Mogler C, Schlesner M, Plass C, Schlereth K, Augustin HG. Dev Cell. 2025 Jan 9:S1534-5807(24)00776-7.

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Lung endothelium exploits susceptible tumor cell states to instruct metastatic latency

Jakab M, Lee KH, Uvarovskii A, Ovchinnikova S, Kulkarni SR, Jakab S, Rostalski T, Spegg C, Anders S, Augustin HG. Nat Cancer. 2024 Feb 2. doi: 10.1038/s43018-023-00716-7. Online ahead of print. PMID: 38308117

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A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Vélez PA, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG. Dev Cell. 2021 Jun 7;56(11):1677-1693.e10. PMID: 34038707

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Understanding angiodiversity: Insights from single cell biology

Jakab M, Augustin HG. Development. 2020 Aug 12;147(15):dev146621. doi: 10.1242/dev.146621. PMID: 32792338

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Tumor cell-derived Angiopoietin-2 promotes metastasis in melanoma

Abdul Pari AA, Singhal M, Hübers C, Mogler C, Schieb B, Gampp A, Gengenbacher N, Reynolds LE, Terhardt D, Géraud C, Utikal J, Thomas M, Goerdt S, Hodivala-Dilke KM, Augustin HG#, Felcht M.# Cancer Res. 2020 Jun 15;80(12):2586-2598. doi: 10.1158/0008-5472.CAN-19-2660. Epub 2020 Apr 17. (#equally contributing last authors) PMID: 32303578

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Preclinical validation of a novelmetastasis inhibiting Tie1 function-blocking antibody

Singhal M, Gengenbacher N, La Porta S, Gehrs S, Shi J, Kamiyama M, Bodenmiller DM, Fischl A, Schieb B, Besemfelder E, Chintharlapalli S, Augustin HG. EMBO Mol Med. 2020 Jun 8;12(6):e11164. doi: 10.15252/emmm.201911164. Epub 2020 Apr 17. PMID: 32302470

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Endothelial cell fitness dictates the source of regenerating liver vasculature

Singhal, M.#, X. Liu#, D. Inverso, K. Jiang, J. Dai, H. He, S. Bartels, W. Li, A.A. Abdul Pari, N. Gengenbacher, E. Besemfelder, L. Hui, H.G. Augustin§, J. Hu§. J Exp Med. 2018 Oct 1;215(10):2497-2508. doi: 10.1084/jem.20180008. Epub 2018 Sep 7. (#equally contributing first authors; §equally contributing senior authors). PMID: 30194265.

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The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium

Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG. Elife. 2018 May 11;7. PMID:29749927

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