Welcome to the homepage of the SFB/CRC 1324 !

Mechanisms and functions of Wnt signaling

The Collaborative Research Center (CRC)/ Sonderforschungsbereich (SFB) 1324 will be funded by DFG for additional four years!

Wnt Young Investigator Program

Are you an early career researcher with an interest in #Wnt signaling?
Do you want to join an interactive collaborative research center?


Then, apply for our #Wnt Young Investigator Program!
Deadline for application: October 31, 2021.


Open Positions

Join our SFB 1324 to become part of an interactive and interdisciplinary team with a focus on Wnt signaling!

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Open doctoral positions

    • Irmgard Sinning (Heidelberg University, Biochemistry Center): Mechanisms of Wnt protein secretion
    • Hellmut Augustin (Heidelberg University and the German Cancer Research Center): Mechanisms of vascular Wnt signaling during liver homeostasis and tumorigenesis
    • Britta Brügger (Heidelberg University, Biochemistry Center): Roles of lipids in Wnt secretion and signaling
    • G. Ulrich Nienhaus (Karlsruhe Institute of Technology): Quantitative fluorescence microscopy for the analysis of Wnt pathway interactions and dynamics
    • Gary Davidson (Karlsruhe Institute of Technology): Quantitative fluorescence microscopy for the analysis of Wnt pathway interactions and dynamics
    • Florian Leuschner (University Hospital Heidelberg): Cell-specific activation of Wnt signaling in healing after myocardial infarction
    • Christof Niehrs (German Cancer Research Center, Heidelberg): Role of DDX56 in GSK3β regulation during Wnt signaling
    • Matias Simons (University Hospital Heidelberg): Wnt-cilia signaling in epithelial polarization and renal development


Open postdoctoral positions

  • Gislene Pereira (Heidelberg University, Centre for Organismal Studies): Wnt-cilia signaling in epithelial polarization and renal development
  • Thomas Holstein (Heidelberg University, Centre for Organismal Studies): Wnt interactions in Hydra development and regeneration

Wnt Seminar

Monday, January 10, 3pm


Anja Tursch (A05, Holstein):

“How generic wound signals are integrated into positional cues - stage-specific functions of Wnt/ beta-catenin signaling during Hydra regeneration”


Motomu Tanaka (A05):

"Coupling of Wnt signaling and mechanical cues"





Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11:e64498. doi: 10.7554/eLife.64498. PMID: 35014953

Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd


Lee H, Sun R, Niehrs C. J Biol Chem. 2022 Jan 12:101586. doi: 10.1016/j.jbc.2022.101586. Online ahead of print. PMID: 35032551

Public outreach

(Heidelberg University)
New Findings on Body Axis Formation
Ziegler B, Yiallouros I, Trageser B, Kumar S, Mercker M, Kling S, Fath M, Warnken U, Schnölzer M, Holstein TW, Hartl M, Marciniak-Czochra A, Stetefeld J, Stöcker W, Özbek S. BMC Biol. 2021 Jun 9;19(1):120. doi: 10.1186/s12915-021-01046-9. PMID: 34107975


SFB1324 Management office

Heidelberg University

Centre for Organismal Studies (COS)

Im Neuenheimer Feld 230

69120 Heidelberg



Photo gallery

Quelle: 20200215_RNZ_HEIDELBERG_HD_27


Überlebensstrategien 13.02.2020

SFB1324: "Musterbildung"

Photo: C.Bastert


2nd SFB1324 Retreat 27.-28.05.2019

Tagungszentrum Villa Bosch, Heidelberg


Alexander Aulehla appointed as Head of EMBL’s Developmental Biology Unit


(July 02, 2021, Heidelberg)

Alexander Aulehla and Ana Martin-Villalba

Elected EMBO Members

(July 07, 2020, Heidelberg)

Prof. Jeroen Krijgsveld received Award for Mass Spectrometry in Life Sciences 2020

(March 2020, DGMS)



Herbert Steinbeisser M.D. Fellowships

In memory of Professor Dr. Herbert Steinbeisser, the SFB1324 offers fellowships to support medical students during experimental research projects that comprise part of their M.D. thesis. Further information can be found here: Herbert Steinbeisser Fellowships


Applications can be submitted twice annually, by June 15th and December 15th.