Wnt Workshop 2023
17/03/2023
Marsilius Kolleg, Heidelberg

Wnt signaling as a drug target in human diseases – challenges and prospects
Free registration :
https://www.conferencecentral.org/signup/signup?t=d33adcc9-6395-48a5-9955-a4998b9f26b4
Registration for the Zoom Webinar:
https://us06web.zoom.us/webinar/register/WN_LJDkqkTTS4i5gLx-Hb9BDg
Venue:
Marsilius Kolleg
Im Neuenheimer Feld 130.1
69120 Heidelberg
SPEAKERS
Stephane Angers (University of Toronto & AntlerA, CA)
W. Matthijs Blankesteijn (Maastricht University, NL)
Felipe de Sousa e Melo (Genentech, US)
Sebastian Guettler (Institute of Cancer Research London, UK)
Madelon Maurice (University Medical Center Utrecht, NL)
Pernilla Sandwall (WntResearch, SE)
David Virshup (Duke-NUS Medical School, SG)
Laura Zelarayán (University of Göttingen, DE)
Chair: Michael Boutros
09:30 – 09:45 Welcome
Michael Boutros (Heidelberg University and DKFZ)
09:45 – 10:15 Pernilla Sandwall (WntResearch, SE):
“Foxy-5, a novel WNT5A mimicking peptide preventing the metastatic process, in clinical development for colon cancer”
10:15 – 10:45 Madelon Maurice (University Medical Center Utrecht, NL):
” SureTACs: a novel strategy for targeted membrane protein degradation in cancer”
10:45 – 11:15 Coffee break
Chair: Sergio Acebrón
11:15 – 11:45 Florian Leuschner (Heidelberg University Hospital, DE):
“Wnt activation after myocardial infarction”
11:45 – 12:15 W. Matthijs Blankesteijn (Maastricht University, NL):
“Interventions in WNT signaling stimulate cardiac regeneration”
12:15 – 12:45 Laura Zelarayán (University of Göttingen, DE):
“CRISPR/Cas9-directed Wnt transcriptional network modulation to prevent heart failure development”
12:45 – 13:00 Ki Hong Lee (Heidelberg University and DKFZ, DE):
“A mechanosensitive self-fueling vascular Wnt dictates zonated liver function”
13:00 – 14:15 Lunch break
Chair: Florian Leuschner
14:15 – 14:45 Tianzuo Zhan (University Hospital Mannheim and Heidelberg University, DE):
“Interaction of Ras and Wnt signaling in colorectal cancer”
14:45 – 15:15 Felipe de Sousa e Melo (Genentech, US)
“Exploiting the oncogenic state of colorectal cancer for therapeutic development”
15:15 – 15:30 Sergio Acebrón (Heidelberg University, DE)
“USP42 functions as a molecular switch between Wnt and p53 signaling in colorectal cancer cells“
15:30 – 16:00 Coffee break
Chair: Tianzuo Zhan
16:00 – 16:30 Sebastian Guettler (Institute of Cancer Research London, UK):
“Molecular mechanisms and regulation of the beta-catenin destruction complex”
16:30 – 17:00 David Virshup (Duke-NUS Medical School, SG):
“PORCN inhibition in Wnt-addicted cancers”
17:00 – 17:30 Stephane Angers (University of Toronto & AntlerA, CA):
“Development of antibody-based Wnt agonists for regenerative medicine”
17:30 – 17:45 Concluding remarks and general discussion
Florian Leuschner, Tianzuo Zhan
