Wnt Workshop 2023

Stephane Angers (University of Toronto & AntlerA, CA)
W. Matthijs Blankesteijn (Maastricht University, NL)
Felipe de Sousa e Melo (Genentech, US)
Sebastian Guettler (Institute of Cancer Research London, UK)
Madelon Maurice (University Medical Center Utrecht, NL)
Pernilla Sandwall (WntResearch, SE)
David Virshup (Duke-NUS Medical School, SG)
Laura Zelarayán (University of Göttingen, DE)

PROGRAM

Chair: Michael Boutros

09:30 – 09:45              Welcome

Michael Boutros (Heidelberg University and DKFZ)

09:45 – 10:15              Pernilla Sandwall (WntResearch, SE):

“Foxy-5, a novel WNT5A mimicking peptide preventing the metastatic process, in clinical development for colon cancer”

10:15 – 10:45              Madelon Maurice (University Medical Center Utrecht, NL):

” SureTACs: a novel strategy for targeted membrane protein degradation in cancer”

10:45 – 11:15             Coffee break

Chair: Sergio Acebrón

11:15 – 11:45              Florian Leuschner (Heidelberg University Hospital, DE):

“Wnt activation after myocardial infarction”

11:45 – 12:15              W. Matthijs Blankesteijn (Maastricht University, NL):

“Interventions in WNT signaling stimulate cardiac regeneration”

12:15 – 12:45              Laura Zelarayán (University of Göttingen, DE):

“CRISPR/Cas9-directed Wnt transcriptional network modulation to prevent heart failure development”

12:45 – 13:00             Ki Hong Lee (Heidelberg University and DKFZ, DE):

“A mechanosensitive self-fueling vascular Wnt dictates zonated liver function”

13:00 – 14:15             Lunch break

Chair: Florian Leuschner

14:15 – 14:45              Tianzuo Zhan (University Hospital Mannheim and Heidelberg University, DE):

“Interaction of Ras and Wnt signaling in colorectal cancer”

14:45 – 15:15              Felipe de Sousa e Melo (Genentech, US)

                                   “Exploiting the oncogenic state of colorectal cancer for therapeutic development”

15:15 – 15:30               Sergio Acebrón (Heidelberg University, DE)

                                    “USP42 functions as a molecular switch between Wnt and p53 signaling in colorectal cancer cells“

15:30 – 16:00              Coffee break

Chair: Tianzuo Zhan

16:00 – 16:30              Sebastian Guettler (Institute of Cancer Research London, UK):

“Molecular mechanisms and regulation of the beta-catenin destruction complex”

16:30 – 17:00              David Virshup (Duke-NUS Medical School, SG):

“PORCN inhibition in Wnt-addicted cancers”

17:00 – 17:30              Stephane Angers (University of Toronto & AntlerA, CA):

“Development of antibody-based Wnt agonists for regenerative medicine”

17:30 – 17:45              Concluding remarks and general discussion

Florian Leuschner, Tianzuo Zhan