Dr. Gary Davidson
Project Leader A06
Karlsruhe Institute of Technology (KIT)
Institute of Biological and Chemical Systems -
Functional Molecular Systems (IBCS-FMS)
Building 319; room 144
Hermann-von-Helmholtz-Platz 1
D-76344 Eggenstein-Leopoldshafen
gary.davidson@kit.edu

Professional Career
since 2012
Co-founder and CEO
ScreenFect GmbH
since 2008
Group leader
Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT)
2000-2008
Postdoctoral work
in laboratory of Christof Niehrs (Molecular Embryology), DKFZ, Heidelberg
2000
PhD
EMBL, Heidelberg
1996-2000
PhD thesis
EMBL, Heidelberg; PhD work in Developmental Biology Programme, group of Rolf Zeller. “Role of FGF signalling in epithelial-mesenchymal-transition (EMT)”
1986-1996
Scientific Officer
Department of Molecular Endocrinology, Rowett Research Institute, Aberdeen, UK
1995
BSc (Honors) in biochemistry
University of Aberdeen, UK
Achievements & Awards
2012
KIT Associate Fellow
Karlsruhe Institute of Technology (KIT)
1990
Awarded EMBL Predoctoral fellowship
European Molecular Biology Laboratory (EMBL)
1990
Funding from Rowett Institute
to study at Aberdeen University
1990
Sunblest prize
Aberdeen’s best applied-science student
Publications
NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model
N-Glycosylation of LRP6 by B3GnT2 Promotes Wnt/β-Catenin Signalling
LRPs in WNT Signalling
Davidson G. Handb Exp Pharmacol. 2021;269:45-73. doi: 10.1007/164_2021_526. PMID: 34490514
Learn moreQuantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments
ACS Pharmacol Transl Sci. 2021 May 11;4(3):1235-1245. doi: 10.1021/acsptsci.1c00084. eCollection 2021 Jun 11. PMID: 34151213
Learn moreMeasuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled
Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G. J Biol Chem. 2020 May 7. pii: jbc.RA120.012892. PMID:32381507
Learn moreFam83F induces p53 stabilisation and promotes its activity
Cell Death Differ. 2019 Oct;26(10):2125-2138. doi: 10.1038/s41418-019-0281-1. Epub 2019 Jan 28. PMID: 30692643
Learn moreDual-color dual-focus line-scanning FCS for quantitative analysis of receptor-ligand interactions in living specimens
Sci Rep. 2015 May 7;5:10149. doi: 10.1038/srep10149. PMID: 25951521
Learn moreTyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signaling
EMBO Rep. 2014 Dec;15(12):1254-67. doi: 10.15252/embr.201439644. Epub 2014 Nov 12. PMID: 25391905
Learn moreMitotic wnt signaling promotes protein stabilization and regulates cell size
Mol Cell. 2014 May 22;54(4):663-74. doi: 10.1016/j.molcel.2014.04.014. Epub 2014 May 15. PMID: 24837680
Learn moreCell cycle control of wnt receptor activation
Dev Cell. 2009 Dec;17(6):788-99. doi: 10.1016/j.devcel.2009.11.006. PMID: 20059949
Learn more