Dr. Gary Davidson

Project Leader A06

Karlsruhe Institute of Technology (KIT)
Institute of Biological and Chemical Systems -
Functional Molecular Systems (IBCS-FMS)
Building 319; room 144
Hermann-von-Helmholtz-Platz 1
D-76344 Eggenstein-Leopoldshafen

gary.davidson@kit.edu

https://fms.ibcs.kit.edu/deutsch/davidson.php
Dr. Gary Davidson

Professional Career

since 2012

Co-founder and CEO

ScreenFect GmbH

since 2008

Group leader

Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT)

2000-2008

Postdoctoral work

in laboratory of Christof Niehrs (Molecular Embryology), DKFZ, Heidelberg

2000

PhD

EMBL, Heidelberg

1996-2000

PhD thesis

EMBL, Heidelberg; PhD work in Developmental Biology Programme, group of Rolf Zeller. “Role of FGF signalling in epithelial-mesenchymal-transition (EMT)”

1986-1996

Scientific Officer

Department of Molecular Endocrinology, Rowett Research Institute, Aberdeen, UK

1995

BSc (Honors) in biochemistry

University of Aberdeen, UK

Achievements & Awards

2012

KIT Associate Fellow

Karlsruhe Institute of Technology (KIT)

1990

Awarded EMBL Predoctoral fellowship

European Molecular Biology Laboratory (EMBL)

1990

Funding from Rowett Institute

to study at Aberdeen University

1990

Sunblest prize

Aberdeen’s best applied-science student

Publications

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model

Grätz L, Sajkowska-Kozielewicz JJ, Wesslowski J, Kinsolving J, Bridge LJ, Petzold K, Davidson G, Schulte G, Kozielewicz P. Br J Pharmacol. 2023 Apr 13. doi: 10.1111/bph.16090. Online ahead of print. PMID: 37055379

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N-Glycosylation of LRP6 by B3GnT2 Promotes Wnt/β-Catenin Signalling

Xu R, Wang X, Safi S, Braunegger N, Hipgrave Ederveen A, Rottmann M, Wittbrodt J, Wuhrer M, Wesslowski J, Davidson G. Cells. 2023 Mar 10;12(6):863. doi: 10.3390/cells12060863. PMID: 36980204

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LRPs in WNT Signalling

Davidson G. Handb Exp Pharmacol. 2021;269:45-73. doi: 10.1007/164_2021_526. PMID: 34490514  

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Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments

Kozielewicz P, Shekhani R, Moser S, Bowin CF, Wesslowski J, Davidson G, Schulte G. ACS Pharmacol Transl Sci. 2021 May 11;4(3):1235-1245. doi: 10.1021/acsptsci.1c00084. eCollection 2021 Jun 11. PMID: 34151213

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Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

Eckert AF, Gao P, Wesslowski J, Wang X, Rath J, Nienhaus K, Davidson G, Nienhaus GU. Elife. 2020 May 22;9:e55286.

PMID: 32441251

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eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G. J Biol Chem. 2020 May 7. pii: jbc.RA120.012892. PMID:32381507

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Fam83F induces p53 stabilisation and promotes its activity

Salama M, Benitez-Riquelme D, Elabd S, Munoz L, Zhang P, Glanemann M, Mione MC, Goldin R, Soussi T, Davidson G, Blattner C. Cell Death Differ. 2019 Oct;26(10):2125-2138. doi: 10.1038/s41418-019-0281-1. Epub 2019 Jan 28. PMID: 30692643

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Dual-color dual-focus line-scanning FCS for quantitative analysis of receptor-ligand interactions in living specimens

Dörlich RM, Chen Q, Niklas Hedde P, Schuster V, Hippler M, Wesslowski J, Davidson G, Nienhaus GU. Sci Rep. 2015 May 7;5:10149. doi: 10.1038/srep10149. PMID: 25951521

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Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signaling

Chen Q, Su Y, Wesslowski J, Hagemann AI, Ramialison M, Wittbrodt J, Scholpp S, Davidson G. EMBO Rep. 2014 Dec;15(12):1254-67. doi: 10.15252/embr.201439644. Epub 2014 Nov 12. PMID: 25391905

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Mitotic wnt signaling promotes protein stabilization and regulates cell size

Acebron SP, Karaulanov E, Berger BS, Huang YL, Niehrs C. Mol Cell. 2014 May 22;54(4):663-74. doi: 10.1016/j.molcel.2014.04.014. Epub 2014 May 15. PMID: 24837680

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Cell cycle control of wnt receptor activation

Davidson G, Shen J, Huang YL, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M, Niehrs C. Dev Cell. 2009 Dec;17(6):788-99. doi: 10.1016/j.devcel.2009.11.006. PMID: 20059949

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Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, Niehrs C. Science. 2007 Jun 15;316(5831):1619-22. doi: 10.1126/science.1137065.
PMID: 17569865

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Nature. 2005 Dec 8;438(7069):867-72. doi: 10.1038/nature04170.
PMID: 16341016

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