Prof. Dr. Jeroen Krijgsveld

Project Leader Z04

Heidelberg University/ Medical Faculty Heidelberg
Division Proteomics of Stem Cells and Cancer / DKFZ
Im Neuenheimer Feld 581
69120 Heidelberg

Prof. Dr. Jeroen Krijgsveld

Professional Career

since 2016

Full Professor for Proteomics

Heidelberg University, Medical Faculty Heidelberg, Excellence Cluster CellNetworks, Heidelberg

since 2016

Head of Division

Proteomics of Stem Cells and Cancer, German Cancer Research Center, Heidelberg


Research Team Leader and Head of the Proteomics Core Facilty

European MolecularBiology Laboratory (EMBL), Heidelberg


Assistant Professor

Utrecht University, Utrecht, The Netherlands


Postdoctoral research fellow

Prof. Steven Gygi, Harvard Medical School, Boston, USA


Postdoctoral research fellow

Prof. Albert Heck, Utrecht University, Utrecht, The Netherlands


Postdoctoral research fellow

Prof.Frans Nijkamp, Utrecht University, Utrecht, The Netherlands



University of Amsterdam, The Netherlands. Advisor: Prof. J. Dankert.

Achievements & Awards

since 2020


Research consortium SMART-CARE, one of the four BMBF-funded ‘Forschungskerne für Massenspektrometrie in der Systemmedizin’


‘Mass spectrometry in the life sciences’ award

German Mass Spectrometry Society (Deutsche Gesellschaft für Massenspektrometrie, DGMS), for ‘outstanding method developments in, and applications of, mass spectrometry in the life sciences’


Inaugural award

Netherlands Society for Mass Spectrometry (NVMS) for outstanding research



Scientific Advisory Board FP7 program ‘SystemAge’

since 2012

Associate Editor

BMC Genomics

since 2007

Co-founder and board member

‘Proteome biology of Stem Cells’ initiative, resorting under the Human Proteome Organization (HUPO)


Board member

Association of Biomolecular Research Facilities (ABRF), Proteomics Research Group


VIDI grant

NWO (Netherlands Organisation for Scientific Research)


Board member

Netherlands Society for Mass Spectrometry (NVMS)


Horizon Breakthrough grant

NWO (Netherlands Organisation for Scientific Research)


High Potential grant

Utrecht University (in collaboration with Prof. Frank Holstege)


NWO Genomics Fellowship

Netherlands Genomics Initiative


Project leader

‘Quantitative proteomics’ Program of the Netherlands Proteomics Center



Analytical Expertise Center of the Netherlands Proteomics Center


Co-founder and board member

Netherlands Proteomics Platform (part of Dutch Biochemical Society)


DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2

Fatti E, Hirth A, Švorinić A, Günther M, Stier G, Cruciat CM, Acebrón SP, Papageorgiou D, Sinning I, Krijgsveld J, Höfer T, Niehrs C. Sci Signal. 2023 Apr 25;16(782):eabp8923. doi: 10.1126/scisignal.abp8923. Epub 2023 Apr 25. PMID: 37098120

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Cracking chromatin with proteomics: From chromatome to histone modifications

Sigismondo G, Papageorgiou DN, Krijgsveld J. Proteomics. 2022 May 28:e2100206. doi: 10.1002/pmic.202100206. Online ahead of print. PMID: 35633285

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Genomic rewiring of SOX2 chromatin interaction network during differentiation of ESCs to postmitotic neurons

Bunina D, Abazova N, Diaz N, Noh KM, Krijgsveld J, Zaugg JB. Cell Syst. 2020 Jun 24;10(6):480-494.e8. doi: 10.1016/j.cels.2020.05.003. Epub 2020 Jun 17.

PMID: 32553182

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Secretome Analysis of Cardiomyocytes Identifies PCSK6 (Proprotein Convertase Subtilisin/Kexin Type 6) as a Novel Player in Cardiac Remodeling After Myocardial Infarction

Kuhn TC, Knobel J, Burkert-Rettenmaier S, Li X, Meyer IS, Jungmann A, Sicklinger F, Backs J, Lasitschka F, Müller OJ, Katus HA, Krijgsveld J*, Leuschner F*. Circulation. 2020 May 19;141(20):1628-1644. doi: 10.1161/CIRCULATIONAHA.119.044914. Epub 2020 Feb 26. *Joint senior authors.
PMID: 32100557

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Protease‐resistant streptavidin for interaction proteomics

Rafiee MR, Sigismondo G, Kalxdorf M, Förster L, Brügger B, Béthune J, Krijgsveld J. Mol Syst Biol. 2020 May;16(5):e9370. PMID: 32400114

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Multi-level and lineage-specific interactomes of the Hox transcription factor Ubx contribute to its functional specificity

Carnesecchi J, Sigismondo G, Domsch K, Baader CEP, Rafiee MR, Krijgsveld J, Lohmann I. Nat Commun. 2020 Mar 13;11(1):1388. doi: 10.1038/s41467-020-15223-x. PMID: 32170121

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Automated sample preparation with SP3 for low-input clinical proteomics

Müller T, Kalxdorf M, Longuespée R, Kazdal DN, Stenzinger A, Krijgsveld J. Mol Syst Biol. 2020 Jan;16(1):e9111. doi: 10.15252/msb.20199111. PMID: 32129943

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The human RNAbinding proteome and its dynamics during arsenite-induced translational arrest

Trendel J, Schwarzl T, Horos R, Prakash A, Bateman A, Hentze MW, Krijgsveld J. Cell. 2019 Jan 10;176(1-2):391-403.e19. doi: 10.1016/j.cell.2018.11.004. Epub 2018 Dec 6. PMID: 30528433

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Single-pot, solid-phase-enhanced sample preparation for proteomics experiments

Hughes CS, Moggridge S, Müller T, Sorensen PH, Morin GB, Krijgsveld J. Nat Protoc. 2019 Jan;14(1):68-85. doi: 10.1038/s41596-018-0082-x.
PMID: 30464214

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Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC)

Buczak K, Ori A, Kirkpatrick JM, Holzer K, Dauch D, Roessler S, Endris V, Lasitschka F, Parca L, Schmidt A, Zender L, Schirmacher P, Krijgsveld J, Singer S, Beck M. Mol Cell Proteomics. 2018 Apr;17(4):810-825. doi: 10.1074/mcp.RA117.000189. Epub 2018 Jan 23. PMID: 29363612

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Expanding the circuitry of pluripotency by selective isolation of chromatin-associated proteins

Rafiee MR, Girardot C, Sigismondo G, Krijgsveld J. Mol Cell. 2016 Nov 3;64(3):624-635. doi: 10.1016/j.molcel.2016.09.019. Epub 2016 Oct 20. PMID: 27773674

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Selective enrichment of newly synthesized proteins for quantitative secretome analysis

Eichelbaum K, Winter M, Berriel Diaz M, Herzig S, Krijgsveld J. Nat Biotechnol. 2012 Oct;30(10):984-90. doi: 10.1038/nbt.2356. Epub 2012 Sep 23.
PMID: 23000932

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