Prof. Dr. Irmgard Sinning

Project Leader A01, B07

Heidelberg University
Biochemistry Center (BZH)
Im Neuenheimer Feld 328
69120 Heidelberg

irmi.sinning@bzh.uni-heidelberg.de

https://bzh.db-engine.de/default.asp?lfn=2241&fg=3528

Professional Career

2006-2019

Board of BZH Directors

Heidelberg University

2006-2009

Managing Director of the BZH

Heidelberg University

since 2000

Full Professor (C4)

BZH, Heidelberg

1994-2000

Group Leader

Structural Biology Program, EMBL, Heidelberg

1991-1993

Scientist

Biomedical Centre, Uppsala University, Dept. Prof. Dr. Alwyn Jones, Sweden

1989 -1991

Postdoctoral fellow

MPI for Biophysics, Frankfurt, Dept. Prof. H. Michel, Germany

1989

PhD in Biochemistry

LMU Munich

Achievements & Awards

2019

Elected member

Berlin-Brandenburg Academy of Sciences (BBAW)

2019

Eduard Buchner Prize

GBM

since 2017

Member of the Steering Committee

DFG Collaborative Research Center (SFB 1324)

since 2017

EMBO-YIP panel member

European Molecular Biology Organization

since 2017

Founding Member

cryo-EM network at Heidelberg University (HDcryoNet)

since 2017

Member of the SAB

IBS, Grenoble

2016

Elected member

Heidelberg Academy of Sciences and Humanities

since 2015

Member of the SAB

Max-Planck-Institute for Developmental Biology, Tübingen

since 2015

Member of the DFG nomination committee

Leibniz programme

2014

Karl Friedrich Bonnhoeffer Lecture

MPI-BPC Göttingen

2014

Bayrische Verfassungsmedaille

award by the German state Bavaria

2014

Großer Forschungspreis

Heidelberg University

2014

Gottfried Wilhelm Leibniz Preis

DFG

2013

Member

ERC starting grants selection committee

2012-2019

Steering Committee

Cluster of Excellence CellNetworks

2012-2016

Chairperson

DFG expert panel “Biochemistry/Biophysics”

2011-2013

President

GBM

2010-2017

Member

Helmholtz Senate Committee

2010

HMLS (Heidelberg Molecular Life Science) investigator award

Heidelberg University

2010

Elected member

Leopoldina

2010

Elected member of EMBO

European Molecular Biology Organization

2008-2016

Member

DFG expert panel “Biochemistry/Biophysics”

2008-2016

Member of the steering committee

DFB Collaborative Research Center SFB 638

2007-2015

Board member

GBM

2001-2015

Editor

FEBS letters

1999-2001

Chairperson

ESRF beam time committee “Life Sciences”

1994-2000

Organizer

four EMBO practical courses “Current methods in membrane protein research”

ongoing

Member

Minerva-FemmeNET (mentoring of female scientists)

Publications

DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2

Fatti E, Hirth A, Švorinić A, Günther M, Stier G, Cruciat CM, Acebrón SP, Papageorgiou D, Sinning I, Krijgsveld J, Höfer T, Niehrs C. Sci Signal. 2023 Apr 25;16(782):eabp8923. doi: 10.1126/scisignal.abp8923. Epub 2023 Apr 25. PMID: 37098120

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Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex

McDowell, M.A., M. Heimes, F. Fiorentino, S. Mehmood, Á. Farkas, J. Coy-Vergara, D. Wu, J.R. Bolla, V. Schmid, R. Heinze, K. Wild, D. Flemming, S. Pfeffer, B. Schwappach, C.V. Robinson, and I. Sinning. Mol Cell. 2020 Oct 1;80(1):72-86.e7. doi: 10.1016/j.molcel.2020.08.012. Epub 2020 Sep 9. PMID: 32910895

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The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb

Zhang Y, Valentín Gesé G, Conz C, Lapouge K, Kopp J, Wölfle T, Rospert S, Sinning I. Nat Commun. 2020 Mar 20;11(1):1504. doi: 10.1038/s41467-020-15313-w. PMID: 32198371

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MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

Wild K, Aleksić M, Lapouge K, Juaire KD, Flemming D, Pfeffer S, Sinning I. Nat Commun. 2020 Feb 7;11(1):776. doi: 10.1038/s41467-020-14603-7. PMID: 32034140

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Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex

Weyer FA, Gumiero A, Gesé GV, Lapouge K, Sinning I. Nat Struct Mol Biol. 2017 Feb;24(2):144-151. doi: 10.1038/nsmb.3349. Epub 2017 Jan 9.
PMID: 28067917

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Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex

Stefer S, Reitz S, Wang F, Wild K, Pang YY, Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V, Dötsch V, Sinning I. Science. 2011 Aug 5;333(6043):758-62. doi: 10.1126/science.1207125. Epub 2011 Jun 30. PMID: 21719644

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