Wnt signaling in fate determination of retinal precursors

Funding period: 2017-2021

Project B04 ended

Project Leaders

Prof. Dr. Joachim Wittbrodt

Prof. Dr. Joachim Wittbrodt

Project Leader B04


The continuous growth of fish retina requires life-long differentiation of retinal progenitor cells into the proper numbers of terminally differentiated neurons of the mature retina. In this process, both, proliferation and differentiation of progenitor cells are tightly coordinated. We address the impact of the Wnt signaling pathway by clonal interference and quantitation of downstream reporters. This will address the relative contribution of canonical Wnt signaling to proliferation and differentiation of specific progenitor cells along the differentiation cascade. The quantitative analysis will allow establishing a mathematical model to predict and test the impact of Wnt signaling in other contexts

Project-related Publications

Igf signaling couples retina growth with body growth by modulating progenitor cell division

Becker C, Lust K, Wittbrodt J. Development. 2021 Mar 15:dev.199133. doi: 10.1242/dev.199133. Online ahead of print.
PMID: 33722901

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Enhanced in vivo-imaging in medaka by optimized anaesthesia, fluorescent protein selection and removal of pigmentation

Lischik CQ, Adelmann L, Wittbrodt J. PLoS One. 2019 Mar 7;14(3):e0212956. PMID: 30845151

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