The role of Wnt signaling in controlling neuromesodermal progenitor cell plasticity in teleost species

Abstract

We will investigate how Wnt signaling gates the fate decisions of neuromesodermal progenitor cells in two fish species, zebrafish and medaka, during posterior axis development. Using a combination of advanced functional tools (e.g. Wnt reporters, fate mapping, endogenous TF-tagging), single-cell transcriptomics, and live imaging, we will test the impact of Wnt signaling on the fate decisions and how this conserved population integrates a common pathway to coordinate distinct outcomes between two species.