Research Article

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

cancer cell biology CRISPR ctnnb1 endogenous tagging FCS fluorescence correlation spectroscopy genetics genomics human β-catenin oncogenic signaling Wnt signaling
Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11:e64498. doi: 10.7554/eLife.64498.
PMID: 35014953
Learn more
Research Article

A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

cell biology endocytosis HGF-MET human PTPR tyrosine kinases Wnt signaling ZNRF3
Kim M, Reinhard C, Niehrs C. Elife. 2021 Sep 30;10:e70885. doi: 10.7554/eLife.70885.
PMID: 34590584
Learn more
Research Article

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

cell biology developmental biology human LRP6 PTPRK spemann organizer tyrosine phosphatase Wnt signaling xenopus ZNRF3

Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. Elife. 2020 Jan 14;9. pii: e51248.

PMID: 31934854

Learn more
Research Article

The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium

computational biology developmental biology DNA methylation endothelial epigenome endothelial quiescence endothelial trsanscriptome human mouse stem cells systems biology TGFß

Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG. Elife. 2018 May 11;7.

PMID:29749927

Learn more