B02

Glycolysis-Wnt signaling axis in development and disease

Funding period: 2017-2029

Project B02

Project Leaders

Dr. Alexander Aulehla

Dr. Alexander Aulehla

 Project Leader B02, B11
Prof. Dr. med. Matias Simons

Prof. Dr. med. Matias Simons

 Project Leader B02

Abstract

A key objective of this funding period is to identify the mechanism that links the glycolytic metabolite FBP with the Wnt signaling pathway. For this, we will test the central hypothesis based on previous data that the FBP-Wnt signaling axis is mediated via Tcf7l2. We will conduct an in-depth investigation of how glycolysis regulates Wnt signaling during somite segmentation and kidney development. In addition, we will explore the role of the glycolysis-Wnt signaling axis in diabetes-associated embryopathy.

Project-related Publications

A noncanonical role of glycolytic metabolites controlling the timing of mouse embryo segmentation

Miyazawa H, Rada J, Prior N, Sanchez PGL, Esposito E, Bunina D, Girardot C, Zaugg J, Aulehla A. Sci Adv. 2025 Sep 19;11(38):eadz9606. doi: 10.1126/sciadv.adz9606. Epub 2025 Sep 19.

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Glycolytic flux-signaling controls mouse embryo mesoderm development

Miyazawa H, Snaebjornsson MT, Prior N, Kafkia E, Hammarén HM, Tsuchida-Straeten N, Patil KR, Beck M, Aulehla A. Elife. 2022 Dec 5;11:e83299. doi: 10.7554/eLife.83299. PMID: 36469462

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Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development

Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A. Dev Cell. 2017 Feb 27;40(4):331-341.e4. doi: 10.1016/j.devcel.2017.01.015. PMID: 28245920

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Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns

Tsiairis CD, Aulehla A. Cell. 2016 Feb 11;164(4):656-67. doi: 10.1016/j.cell.2016.01.028. PMID: 26871631

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Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation

Tsiairis CD, Aulehla A. Cell. 2016 Feb 11;164(4):656-67. doi: 10.1016/j.cell.2016.01.028. PMID: 26871631

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Scaling of embryonic patterning based on phase-gradient encoding

Lauschke VM, Tsiairis CD, François P, Aulehla A. Nature. 2013 Jan 3;493(7430):101-5. doi: 10.1038/nature11804. Epub 2012 Dec 19.
PMID: 23254931

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