Orchestration by the Wnt/Hippo/CD95 signalosome of stem- and EMT-like phenotypes
Funding period: 2017-2025

Project Leaders
Abstract
This project addresses the role of canonical Wnt activity along the “lineage” of normal adult neural stem cells (NSCs) and malignant glioblastoma multiforme (GBM) cells. It capitalizes in the unique combination of single cell transcriptome profiling of TCF/Lef-reporter cells from human and mouse origin, in vivo and in vitro assays to tackle invasion, connectivity and stemness, and mathematical modeling to guide loss and gain of function studies aiming at generating intelligent regenerative and anti-cancer therapies.

Project-related Publications
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Cell. 2019 Mar 7;176(6):1407-1419.e14. PMID: 30827680
Learn moreRevealing age related changes of adult hippocampal neurogenesis using mathematical models
Development. 2018 Jan 8;145(1):dev153544. doi: 10.1242/dev.153544. PMID: 29229768
Learn moreLoss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline
Cell Stem Cell. 2013 Feb 7;12(2):204-14. doi: 10.1016/j.stem.2012.11.010. PMID: 23395445
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