B06

Orchestration by the Wnt/Hippo/CD95 signalosome of stem- and EMT-like phenotypes

Funding period: 2017-2025

Project Leaders

Prof. Dr. Ana Martin-Villalba

Project Leader B06

Abstract

This project addresses the role of canonical Wnt activity along the “lineage” of normal adult neural stem cells (NSCs) and malignant glioblastoma multiforme (GBM) cells. It capitalizes in the unique combination of single cell transcriptome profiling of TCF/Lef-reporter cells from human and mouse origin, in vivo and in vitro assays to tackle invasion, connectivity and stemness, and mathematical modeling to guide loss and gain of function studies aiming at generating intelligent regenerative and anti-cancer therapies.

Project-related Publications

Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain

Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Cell. 2019 Mar 7;176(6):1407-1419.e14. PMID: 30827680

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Revealing age related changes of adult hippocampal neurogenesis using mathematical models

Ziebell F, Dehler S, Martin-Villalba A, Marciniak-Czochra A. Development. 2018 Jan 8;145(1):dev153544. doi: 10.1242/dev.153544. PMID: 29229768

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Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline

Seib DR, Corsini NS, Ellwanger K, Plaas C, Mateos A, Pitzer C, Niehrs C, Celikel T, Martin-Villalba A. Cell Stem Cell. 2013 Feb 7;12(2):204-14. doi: 10.1016/j.stem.2012.11.010. PMID: 23395445

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