Publications

Review

The origin and evolution of Wnt signalling

Holzem M, Boutros M, Holstein TW. Nat Rev Genet. 2024 Feb 19. Online ahead of print. PMID: 38374446

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Research Article

R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient

Lee H, Camuto CM, Niehrs C. Nat Commun. 2024 Feb 2;15(1):1003. doi: 10.1038/s41467-024-44951-7. PMID: 38307837

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Research Article

Lung endothelium exploits susceptible tumor cell states to instruct metastatic latency

Jakab M, Lee KH, Uvarovskii A, Ovchinnikova S, Kulkarni SR, Jakab S, Rostalski T, Spegg C, Anders S, Augustin HG. Nat Cancer. 2024 Feb 2. doi: 10.1038/s43018-023-00716-7. Online ahead of print. PMID: 38308117
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Research Article

A predatory gastrula leads to symbiosis-independent settlement in Aiptasia.

Maegele I, Rupp S, Özbek S, Guse A, Hambleton EA, Holstein TW. Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2311872120. doi: 10.1073/pnas.2311872120. Epub 2023 Sep 25. PMID: 37748072
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Research Article

A temperature-tolerant CRISPR base editor mediates highly efficient and precise gene editing in Drosophila

Doll RM, Boutros M, Port F. Sci Adv. 2023 Sep;9(35):eadj1568. doi: 10.1126/sciadv.adj1568. Epub 2023 Aug 30. PMID: 37647411

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Research Article

Glyoxal as alternative fixative for single cell RNA sequencing

cell fixation glyoxal single cell RNA sequencing transcriptomics
Bageritz J, Krausse N, Yousefian S, Leible S, Valentini E, Boutros M. G3 (Bethesda). 2023 Jul 26:jkad160. doi: 10.1093/g3journal/jkad160. Online ahead of print. PMID: 37494060
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Research Article

ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

lysosome LYTAC PD-L1 PROTAC protein degradation R-spondin RNF43 transmembrane E3 ligase ZNRF3
Sun R, Meng Z, Lee H, Offringa R, Niehrs C. Cell Chem Biol. 2023 Jun 8:S2451-9456(23)00153-8. doi: 10.1016/j.chembiol.2023.05.010. Online ahead of print. PMID: 37321224
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Research Article

DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2

Fatti E, Hirth A, Švorinić A, Günther M, Stier G, Cruciat CM, Acebrón SP, Papageorgiou D, Sinning I, Krijgsveld J, Höfer T, Niehrs C. Sci Signal. 2023 Apr 25;16(782):eabp8923. doi: 10.1126/scisignal.abp8923. Epub 2023 Apr 25. PMID: 37098120
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Research Article

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model

binding affinity shift CRISPR/Cas9 FZD7 NanoBiT/BRET binding SW480 cells Wnt
Grätz L, Sajkowska-Kozielewicz JJ, Wesslowski J, Kinsolving J, Bridge LJ, Petzold K, Davidson G, Schulte G, Kozielewicz P. Br J Pharmacol. 2023 Apr 13. doi: 10.1111/bph.16090. Online ahead of print. PMID: 37055379
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Research Article

Wnt/β-catenin signaling induces axial elasticity patterns of Hydra extracellular matrix

Histology Microscopic anatomy Molecular biology Zoology
Veschgini M, Suzuki R, Kling S, Petersen HO, Bergheim BG, Abuillan W, Linke P, Kaufmann S, Burghammer M, Engel U, Stein F, Özbek S, Holstein TW, Tanaka M. iScience. 2023 Mar 16;26(4):106416. doi: 10.1016/j.isci.2023.106416. eCollection 2023 Apr 21. PMID: 37009232
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Research Article

N-Glycosylation of LRP6 by B3GnT2 Promotes Wnt/β-Catenin Signalling

B3GnT2 glycosylation LRP6 polylactosamine Wnt signalling Wnt/β-catenin
Xu R, Wang X, Safi S, Braunegger N, Hipgrave Ederveen A, Rottmann M, Wittbrodt J, Wuhrer M, Wesslowski J, Davidson G. Cells. 2023 Mar 10;12(6):863. doi: 10.3390/cells12060863. PMID: 36980204
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Review

The Roles of Secreted Wnt Ligands in Cancer

cancer immunotherapy metastasis non-canonical Wnt signaling targeted therapy tumor microenvironment Wnt ligands Wnt signaling

Werner J, Boonekamp KE, Zhan T, Boutros M. Int J Mol Sci. 2023 Mar 10;24(6):5349. doi: 10.3390/ijms24065349. PMID: 36982422

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