Publications

Research Article

WNT5a export onto extracellular vesicles studied at single-molecule and single-vesicle resolution

extracellular vesicles fluorescence correlation spectroscopy number and brightness analysis Wnt signaling WNT transport

Schubert A, Mongkolsittisilp A, Kobitski A, Schulz M, Voloshanenko O, Schaffrinski M, Winkler N, Neßling M, Richter K, Kranz D, Nienhaus K, Jäger D, Trümper L, Büntzel J, Binder C, Nienhaus GU, Boutros M. FEBS J. 2025 Apr 1.

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Research Article

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee KH, Geng Y, Rajbhandari P, Hernandez C, Steffani M, Qie J, Savage T, Goyal DM, Ray KC, Neelakantan TV, Yin D, Melms J, Lehrich BM, Yasaka TM, Liu S, Oertel M, Lan T, Guillot A, Peiseler M, Filliol A, Kanzaki H, Fujiwara N, Ravi S, Izar B, Brosch M, Hampe J, Remotti H, Argemi J, Sun Z, Kendall TJ, Hoshida Y, Tacke F, Fallowfield JA, Blockley-Powell SK, Haeusler RA, Steinman JB, Pajvani UB, Monga SP, Bataller R, Masoodi M, Arpaia N, Lee YA, Stockwell BR, Augustin HG, Schwabe RF. Nature. 2025 Mar 12.

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Research Article

A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA

Smarduch S, Moreno-Velasquez SD, Ilic D, Dadsena S, Morant R, Ciprinidis A, Pereira G, Binder M, García-Sáez AJ, Acebrón SP. EMBO J. 2025 Apr;44(7):2157-2182.

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Review

Digestive cancers: mechanisms, therapeutics and management

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Research Article

Activation of Wnt/β-catenin signaling is critical for the tumorigenesis of choroid plexus

Ho KH, Trapp M, Guida C, Ivanova EL, De Jaime-Soguero A, Jabali A, Thomas C, Salasova A, Bernatík O, Salio C, Horschitz S, Hasselblatt M, Sassoè-Pognetto M, Čajánek L, Ishikawa H, Schroten H, Schwerk C, Acebrón SP, Angel P, Koch P, Patrizi A. Neuro Oncol. 2025 Jan 12;27(1):106-122

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Research Article

The spatial zonation of the murine placental vasculature is specified by epigenetic mechanisms

angiogenesis DNA methylation DNMT3A epigenetic regulation growth retardation placental endothelium spatial zonation

Gehrs S, Jakab M, Gutjahr E, Gu Z, Weichenhan D, Mallm JP, Mogler C, Schlesner M, Plass C, Schlereth K, Augustin HG. Dev Cell. 2025 Jan 9:S1534-5807(24)00776-7.

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Research Article

DNA methylation controls stemness of astrocytes in health and ischaemia

Kremer LPM, Cerrizuela S, El-Sammak H, Al Shukairi ME, Ellinger T, Straub J, Korkmaz A, Volk K, Brunken J, Kleber S, Anders S, Martin-Villalba A. Nature. 2024 Oct;634(8033):415-423. doi: 10.1038/s41586-024-07898-9. Epub 2024 Sep 4. PMID: 39232166
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Research Article

Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress

de Jaime-Soguero A, Hattemer J, Bufe A, Haas A, van den Berg J, van Batenburg V, Das B, di Marco B, Androulaki S, Böhly N, Landry JJM, Schoell B, Rosa VS, Villacorta L, Baskan Y, Trapp M, Benes V, Chabes A, Shahbazi M, Jauch A, Engel U, Patrizi A, Sotillo R, van Oudenaarden A, Bageritz J, Alfonso J, Bastians H, Acebrón SP. Nat Commun. 2024 Aug 28;15(1):7404. doi: 10.1038/s41467-024-51821-9. PMID: 39191776

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Research Article

DEAD box RNA helicases are pervasive protein kinase interactors and activators

Hirth A, Fatti E, Netz E, Acebron SP, Papageorgiou D, Švorinić A, Cruciat CM, Karaulanov E, Gopanenko A, Zhu T, Sinning I, Krijgsveld J, Kohlbacher O, Niehrs C. Genome Res. 2024 Jul 23;34(6):952-966. doi: 10.1101/gr.278264.123. PMID: 38986579
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Review

The origin and evolution of Wnt signalling

Holzem M, Boutros M, Holstein TW. Nat Rev Genet. 2024 Feb 19. Online ahead of print. PMID: 38374446

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Research Article

R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient

Lee H, Camuto CM, Niehrs C. Nat Commun. 2024 Feb 2;15(1):1003. doi: 10.1038/s41467-024-44951-7. PMID: 38307837

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Research Article

Lung endothelium exploits susceptible tumor cell states to instruct metastatic latency

Jakab M, Lee KH, Uvarovskii A, Ovchinnikova S, Kulkarni SR, Jakab S, Rostalski T, Spegg C, Anders S, Augustin HG. Nat Cancer. 2024 Feb 2. doi: 10.1038/s43018-023-00716-7. Online ahead of print. PMID: 38308117
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