Research Article

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

angiocrine factors liver endothelial cell (L-EC) phosphoproteomics proteomics Tie1 Tie2 transcriptomics vascular zonation Wnt signaling

Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Vélez PA, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG. Dev Cell. 2021 Jun 7;56(11):1677-1693.e10.

PMID: 34038707

Learn more
Research Article

Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments

Frizzled NanoBRET Wnt signaling

Kozielewicz P, Shekhani R, Moser S, Bowin CF, Wesslowski J, Davidson G, Schulte G. ACS Pharmacol Transl Sci. 2021 May 11;4(3):1235-1245. doi: 10.1021/acsptsci.1c00084. eCollection 2021 Jun 11.

PMID: 34151213

Learn more
Research Article

USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling

colorectal cancer deubiquitination EMT LGR4/5/6 mouse intestinal organoids. Wnt signaling
Giebel N, de Jaime-Soguero A, García Del Arco A, Landry JJM, Tietje M, Villacorta L, Benes V, Fernández-Sáiz V, Acebrón SP. EMBO Rep. 2021 Mar 30:e51415. doi: 10.15252/embr.202051415. Online ahead of print.
PMID: 33786993
Learn more
Research Article

Igf signaling couples retina growth with body growth by modulating progenitor cell division

Medaka Organ size Scaling Self-organization
Becker C, Lust K, Wittbrodt J. Development. 2021 Mar 15:dev.199133. doi: 10.1242/dev.199133. Online ahead of print.
PMID: 33722901

 

Learn more
Research Article

Wnt10b GSK3β dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

chromosome stability GSK3β Mitosis Wnt signaling Wnt/STOP Wnt10b
Lin YC, Haas A, Bufe A, Parbin S, Hennecke M, Voloshanenko O, Gross J, Boutros M, Acebron SP, Bastians H. Life Sci Alliance. 2020 Nov 30;4(1):e202000855. Print 2021 Jan.
PMID: 33257473
Learn more
Review

Extracellular vesicles and oncogenic signaling

exosomes extracellular vesicles metastasis microvesicles signaling tumor progression

Schubert A, Boutros M. Mol Oncol. 2020 Nov 18. doi: 10.1002/1878-0261.12855.

PMID: 33207034

Learn more
Research Article

Phosphorylation of Ykt6 SNARE Domain Regulates Its Membrane Recruitment and Activity

membrane attachment secretory pathway trafficking Wnt secretion Ykt6 conformational switch

Karuna M P, Witte L, Linnemannstoens K, Choezom D, Danieli-Mackay A, Honemann-Capito M, Gross JC. Biomolecules. 2020 Nov 16;10(11):E1560.

PMID: 33207719

Learn more
Research Article

R-spondins are BMP receptor antagonists in Xenopus early embryonic development

BMP signaling embryonic development R-spondin Wnt signaling

Lee H, Seidl C, Sun R, Glinka A, Niehrs C. Nat Commun. 2020 Nov 4;11(1):5570. 

PMID: 33149137

Learn more
Research Article

Multiplexed conditional genome editing with Cas12a in Drosophila

Cas12a Cas9 CRISPR Drosophila genome engineering.

Port F, Starostecka M, Boutros M. Proc Natl Acad Sci U S A. 2020 Aug 25:202004655.

PMID: 32843348

Learn more
Research Article

The kinesin motor Klp98A mediates apical to basal Wg transport

endosomal trafficking kinesin transport transcytosis Wnt secretion Wnt signaling
Witte L, Linnemannstöns K, Schmidt K, Honemann-Capito M, Grawe F, Wodarz A, Gross JC. Development. 2020 Aug 14;147(15):dev186833. doi: 10.1242/dev.186833.
PMID: 32665246
Learn more
Research Article

Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium

endosomal sorting morphogen trafficking Wnt secretion Wnt signaling

Linnemannstöns K, Witte L, Karuna P, Kittel J, Danieli A, Müller D, Nitsch L, Honemann-Capito M, Grawe F, Wodarz A, Gross JC. Development. 2020 Aug 14;147(15):dev185421. PMID: 32611603

Learn more
Other

MAPK signaling links the injury response to Wnt-regulated patterning in Hydra regeneration

Tursch, A., M. Lommel, N. Bartsch, and T.W. Holstein. 2020.  bioRxiv, preprint.

Learn more