Research Article

Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis

cilia exencephaly GSK3 lipodystrophy LRP6 PP1 Wnt
Zhang K, Da Silva F, Seidl C, Wilsch-Bräuninger M, Herbst J, Huttner WB, Niehrs C. Dev Cell. 2023 Jan 23;58(2):139-154.e8. doi: 10.1016/j.devcel.2022.12.006. PMID: 36693320
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Research Article

Glycolytic flux-signaling controls mouse embryo mesoderm development

6-bisphosphate developmental biology flux-signaling metabolite fructose 1 metabolic signaling mouse presomitic mesoderm subcellular protein localization Wnt signaling

Miyazawa H, Snaebjornsson MT, Prior N, Kafkia E, Hammarén HM, Tsuchida-Straeten N, Patil KR, Beck M, Aulehla A. Elife. 2022 Dec 5;11:e83299. doi: 10.7554/eLife.83299. PMID: 36469462

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Research Article

Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response

inflammation monocytes myocardial infarction Wnt signaling
Meyer IS, Li X, Meyer C, Voloshanenko O, Pohl S, Boutros M, Katus HA, Frey N, Leuschner F. Int J Mol Sci. 2022 Oct 14;23(20):12252. doi: 10.3390/ijms232012252.
PMID: 36293109
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Research Article

Injury-induced MAPK activation triggers body axis formation in Hydra by default Wnt signaling

Axis formation injury response MAPK signaling regeneration Wnt/beta-catenin
Tursch A, Bartsch N, Mercker M, Schlüter J, Lommel M, Marciniak-Czochra A, Özbek S, Holstein TW. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2204122119. doi: 10.1073/pnas.2204122119. Epub 2022 Aug 22. PMID: 35994642
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Research Article

Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates

biomolecular condensates CRISPR Dishevelled superresolution microscopy Wnt signaling

Schubert A, Voloshanenko O, Ragaller F, Gmach P, Kranz D, Scheeder C, Miersch T, Schulz M, Trümper L, Binder C, Lampe M, Engel U, Boutros M. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122476119. doi: 10.1073/pnas.2122476119. Epub 2022 Jul 22. PMID: 35867833

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Review

Genetically encodable fluorescent protein markers in advanced optical imaging

fluorescence microscopy genetically encodable fluorescent markers GFP-type fluorescent protein super resolution microscopy tetrapyrrole-binding fluorescent protein
Nienhaus K, Nienhaus GU. Methods Appl Fluoresc. 2022 Jun 29. doi: 10.1088/2050-6120/ac7d3f. Online ahead of print.
PMID: 35767981
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Review

Wnt signalling in cell division: from mechanisms to tissue engineering

asymmetric cell division bioengineering chromosome segregation localised Wnt signalling Spindle orientation. stem cells

Habib SJ, Acebrón SP. Trends Cell Biol. 2022 Jun 15:S0962-8924(22)00137-4. doi: 10.1016/j.tcb.2022.05.006. Online ahead of print. PMID: 35717422

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Review

Cracking chromatin with proteomics: From chromatome to histone modifications

cell biology post-translational modification analysis sample preparation signal transduction technology

Sigismondo G, Papageorgiou DN, Krijgsveld J. Proteomics. 2022 May 28:e2100206. doi: 10.1002/pmic.202100206. Online ahead of print. PMID: 35633285

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Review

The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling.

Axis formation Gradients Hydra Nematostella Nodal signaling Tgf-beta signaling Wnt signaling

Holstein TW. Dev Biol. 2022 Apr 22;487:74-98. doi: 10.1016/j.ydbio.2022.04.005. Online ahead of print.

PMID: 35461834

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Review

Cross-Talk between p53 and Wnt Signaling in Cancer

APC beta-catenin cancer drug resistance metastasis p53 Wnt

Xiao Q, Werner J, Venkatachalam N, Boonekamp KE, Ebert MP, Zhan T. Biomolecules. 2022 Mar 15;12(3):453. doi: 10.3390/biom12030453. PMID: 35327645

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Research Article

Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd

AML BMP4 signaling cell differentiation dendrimer development peptides R-spondin2 TSP1 Wnt signaling xenopus
Lee H, Sun R, Niehrs C. J Biol Chem. 2022 Jan 12:101586. doi: 10.1016/j.jbc.2022.101586. Online ahead of print.
PMID: 35032551
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Research Article

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

cancer cell biology CRISPR ctnnb1 endogenous tagging FCS fluorescence correlation spectroscopy genetics genomics human β-catenin oncogenic signaling Wnt signaling
Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11:e64498. doi: 10.7554/eLife.64498.
PMID: 35014953
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