Publications

Research Article

Hysteresis-driven pattern formation in reaction-diffusion-ODE systems

modeling patterning

Alexandra Köthe, Anna Marciniak-Czochra  and  Izumi Takagi. American Institute of Mathematical Science. June  2020, 40(6): 3595-3627. doi: 10.3934/dcds.2020170

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Research Article

Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

correlation analysis ligand-receptor binding affinity live imaging physics of living systems quantitative fluorescence microscopy

Eckert AF, Gao P, Wesslowski J, Wang X, Rath J, Nienhaus K, Davidson G, Nienhaus GU. Elife. 2020 May 22;9:e55286.

PMID: 32441251

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Research Article

Protease‐resistant streptavidin for interaction proteomics

chemical derivatization ChIP-SICAP contamination proteomics streptavidin

Rafiee MR, Sigismondo G, Kalxdorf M, Förster L, Brügger B, Béthune J, Krijgsveld J. Mol Syst Biol. 2020 May;16(5):e9370.

PMID: 32400114

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Research Article

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

bioluminescence resonance energy transfer (BRET) Frizzled fusion protein G protein–coupled receptor (GPCR) ligand binding membrane protein NanoBiT NanoBRET trafficking Wnt signaling

Wesslowski J, Kozielewicz P, Wang X, Cui H, Schihada H, Kranz D, Karuna M P, Levkin P, Gross JC, Boutros M, Schulte G, Davidson G. J Biol Chem. 2020 May 7. pii: jbc.RA120.012892.

PMID:32381507

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Research Article

gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection

Bioconductor Biology-based model CRISPR screen Experimental design Generative probabilistic model Genetic perturbation screen gscreend package

Imkeller K, Ambrosi G, Boutros M, Huber W. Genome Biol. 2020 Mar 2; 21(1):53.

PMID: 32122365

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Research Article

A Large-Scale Resource for Tissue-Specific CRISPR Mutagenesis in Drosophila

conditional mutagenesis CRISPR D. melanogaster developmental biology genetic tools genetics genomics large-scale in vivo screens Resource

Port F, Strein C, Stricker M, Rauscher B, Heigwer F, Zhou J, Beyersdörffer C, Frei J, Hess A, Kern K, Lange L, Langner N, Malamud R, Pavlović B, Rädecke K, Schmitt L, Voos L, Valentini E, Boutros M. Elife. 2020 Feb 13;9:e53865.

PMID: 32053108

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Research Article

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

cell biology developmental biology human LRP6 PTPRK spemann organizer tyrosine phosphatase Wnt signaling xenopus ZNRF3

Chang LS, Kim M, Glinka A, Reinhard C, Niehrs C. Elife. 2020 Jan 14;9. pii: e51248.

PMID: 31934854

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Research Article

Expansion of a single transposable element family is associated with genome-size increase and radiation in the genus Hydra

cnidarian Hydra transposon

Wong WY, Simakov O, Bridge DM, Cartwright P, Bellantuono AJ, Kuhn A, Holstein TW, David CN, Steele RE, Martínez DE. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):22915-22917.

PMID: 31659034

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Research Article

Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium

Drosophila polarized epithelium Wg Wnt secretion Wnt signaling

Chaudhary V, Boutros M. PLoS Genet. 2019 Sep 17;15(9):e1008351.

PMID: 31527874

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Research Article

Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing

Drosophila Frizzled Fz2 Morphogen gradient formation Protein secretion Wg Wing epithelium Wnt signaling

Chaudhary V, Hingole S, Frei J, Port F, Strutt D, Boutros M. Development. 2019 Aug 9;146(15).

PMID: 31399474

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Other

What makes flatworms go to pieces

flatworm regeneration Wnt signaling

Holstein TW. Nature. 2019 Aug;572(7771):593-594.

PMID: 31444489

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Research Article

Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain

inflammation interferon modeling neural stem cells quiescence sFRP5 simulations single-cell transcriptomics stem cell aging subventricular zone Wnt signaling

Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Cell. 2019 Mar 7;176(6):1407-1419.e14.

PMID: 30827680

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